MnTBAP chloride

规格	价格/CNY		数量
5 mg	￥ 248	现货
10 mg	￥ 355	现货
25 mg	￥ 578	现货
50 mg	￥ 990	现货
1 mL * 10 mM (in DMSO)	￥ 397	现货

规格

价格/CNY

货期

数量

5 mg

￥ 248

现货

10 mg

￥ 355

现货

25 mg

￥ 578

现货

50 mg

￥ 990

现货

1 mL * 10 mM (in DMSO)

￥ 397

现货

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

DMSO: 90.0 mg/mL (102.4 mM), Sonication is recommended.

0.5 M NaOH: 18.0 mg/mL (20.5 mM), Sonication is recommended.

1M NaOH: 9.0 mg/mL (10.2 mM), when pH is adjusted to 8 with NaOH. Sonication is recommended.

产品描述	MnTBAP chloride (Mn(III)TBAP) is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger that reduces the doubling time of SOD-E. coli by a factor of 2. MnTBAP chloride exhibits anti-inflammatory effects through upregulation of BMPR-II and inhibition of NFκB signaling. mnTBAP chloride is a manganese porphyrin complex with antioxidant properties and has potential for use in the study of fibrotic responses in chronic kidney diseases (CKDs).
体外活性	Due to its superoxide dismutase mimetic property, 50 microM MnTBAP was found to attenuate the injury produced dose-dependently by exposure to various concentrations of paraquat for 4 h. MnTBAP also protected endothelial cells in a dose-dependent manner against paraquat. The protective effect of MnTBAP appears to be caused by its intracellular superoxide-scavenging activity because neither the zinc form nor CuZnSOD protected the cells against paraquat-induced injury.[1]
体内活性	Local administration of MnTBAP significantly and reduced carrageenan-induced paw oedema dose-dependently at all time points, which was related to its superoxide dismutase mimetic property. MnTBAP also caused a significant dose-dependent reduction in paw myeloperoxidase activity, as well as preventing histological injury. Immunohistochemical analyses for nitrotyrosine showed a positive staining in paw from carrageenan-treated rats.[2]

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