Entacapone sodium salt inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. Entacapone (< 100 μM) is a potent inhibitor of α-syn and β-amyloid (Aβ) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells.Entacapone sodium salt is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment.
Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) promotes normal bone development by regulating calcium. Tacalcitol modulates immunological and inflammatory processes.
cis-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor entacapone. It is also a potential impurity found in commercial preparations of entacapone and a degradant of entacapone formed by UV light exposure.
Tacalcitol (Standard) is the standard substance of Tacalcitol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) promotes normal bone development by regulating calcium. Tacalcitol modulates immunological and inflammatory processes.
Pentacarboxylporphyrin I dihydrochloride 是一种属于卟啉衍生物的有机化合物。它主要用于生化研究中,作为定量生物样品中卟啉及相关化合物的参考标准。在卟啉症的诊断和监测中,此化合物具有多种用途,卟啉症是一类以血红素代谢异常为特征的遗传性疾病。此外,Pentacarboxylporphyrin I dihydrochloride 也用于光动力疗法中,作为光敏剂以改善癌症和其他疾病。