Name: Anti-FZD7 Antibody
Brand: TargetMol
SKU: T9901A-1327
Rating: 4.5 (1 reviews)

生物活性

产品描述	Anti-FZD7 Antibody represents a highly specialized monoclonal antibody specifically engineered to target the human Frizzled-7 receptor with exceptional binding affinity and selectivity, effectively facilitating the measurable blockade of Wnt ligand interaction across various preclinical experimental models to evaluate the inhibition of canonical beta-catenin signaling and tumor-initiating cell frequency during strictly monitored laboratory observation periods in advanced oncology research environments.
体外活性	在 CRISPR 筛选验证和 Wnt 信号测定中，Anti-FZD7 Antibody 阻断了 Wnt-FZD5 信号转导并抑制了 RNF43 突变胰腺肿瘤细胞的生长 [1]。
体内活性	在 RNF43 突变胰腺癌异种移植模型中，通过全身给药方式给予 Anti-FZD7 Antibody 显著减轻了肿瘤负荷并抑制了体内的 Wnt 信号转导 [1]。
别名	抗FZD7 抗体
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型	IgG1 kappa
推荐同型对照	Human IgG1 kappa, Isotype Control

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	O75084
靶点	FZD7

储存&溶解度

存储

Anti-FZD7 Antibody