560
43
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2377 |
Pilaralisib analogue
XL147 analogue,SAR245408 |
Apoptosis; DNA-PK; PI3K | Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
Pilaralisib analogue (XL147 analogue) 是一种选择性和可逆的 I 类 PI3K 抑制剂,用于 PI3Kα/δ/γ。 | |||
T3576 |
CPI-455 analogue
CPI-455 analogue |
Others | Others |
CPI-455 analogue (CPI-455 analogue) 是 CPI-455 的结构类似物,CPI-455 是一种 KDM5 抑制剂。 | |||
T7944 |
VPS34 inhibitor 1 (Compound 19, PIK-III analogue)
PIK-III analogue |
PI3K | PI3K/Akt/mTOR signaling |
VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) 是一种有效的选择性 VPS34抑制剂( IC50 : 15 nM)。 | |||
T12444 |
Phentolamine Analogue 1
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Phentolamine Analogue 1 是 phentolamine 类似物。其中Phentolamine 是非选择性alpha-adrenergic 拮抗剂 。 | |||
T2647 |
IDO5L
INCB024360 analogue,INCB14943 |
IDO; Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
IDO5L (INCB024360 analogue) 是一种有效的吲哚胺-2,3-双加氧酶 (IDO) 抑制剂,IC50=67 nM。 | |||
T1826 |
PI3K-IN-1
Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409 |
DNA-PK; PI3K | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
PI3K-IN-1 (Voxtalisib Analogue) 是 PI3K 抑制剂,PI3K-IN-1(25 μM) 能够阻断 PI3K/Akt 信号通路。 | |||
T3076 |
GLPG0634 analog
GLPG0634 analogue |
Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
GLPG0634 analog (GLPG0634 analogue) 是一种 JAK 广谱性抑制剂,对 JAK1/JAK2/JAK3 的 IC50值为 50 到 200 nM 之间。 | |||
T6921 |
ONO-4059 analog
ONO-4059 analogue,ONO-WG-307,GS-4059 analog |
Apoptosis; BTK | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
ONO-4059 analog (ONO-WG-307) 是 ONO-4059 的类似物,ONO-4059 是一种高效、选择性的口服 BTK 抑制剂,IC50 为 23.9 nM。 | |||
T6705 |
TIC10 Isomer
ONC201 isomer,TIC10 Analogue |
Others | Others |
TIC10 Isomer (ONC201 isomer) 是一种 TIC10 的异构体。它不能诱导 TRIAL 表达的生物学活性。 | |||
T11393 |
GET73
Gamma hydroxybutyric acid analogue,GET 73 |
GluR | Neuroscience |
GET73 (Gamma hydroxybutyric acid analogue) 是天然神经递质 γ-羟基丁酸的类似物。它对谷氨酸在海马的传递有显著的影响。它具有抗酒精和抗焦虑的作用。 | |||
T1806 |
IDO-IN-7
NLG919,Navoximod,NLG-919 analogue,GDC-0919 |
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
IDO-IN-7 (NLG-919 analogue) 是 IDO1 抑制剂,IC50=38 nM。 | |||
T68855 |
Hymenialdisine Analogue #1
|
||
Hymenialdisine Analogue #1 is the indole derivative of Hymenialdisine, a potent inhibitor of a variety of kinases including MEK-1, GSK-3Β, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar concentrations. | |||
T11935 |
Macitentan (n-butyl analogue)
|
Others | Others |
Macitentan n-butyl analogue, a derivative of Macitentan, functions as an orally active dual antagonist targeting both endothelin ETA and ETB receptors. This compound shows promise for treating idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH), leveraging its non-peptide structure for potential therapeutic applications. | |||
T19616 |
D-phenylalanine analogue
(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid |
Others | Others |
(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid, a constrained phenylalanine (Phe) analogue, exhibits the capacity to adopt beta-bend and helical structures, facilitating a preferred side-chain orientation within the peptide. | |||
T22633 |
CCT251545 analogue, Compound 51
|
Others | Others |
CCT251545 analog is a potent and selective CDK8/19 inhibitor (IC50: 5.1 nM and 5.6 nM, respectively). Mediator complex-associated kinases CDK8 and CDK19 are involved in the regulation of multiple transcription pathways. CDK8 plays as an oncogene in gastri | |||
T11549 |
Helioxanthin 8-1
Helioxanthin analogue 8-1 |
Others | Others |
Helioxanthin 8-1, an analogue of helioxanthin, exhibits significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 μM. | |||
T74641 | Rezivertinib analogue 1 | ||
Rezivertinib analogue 1 是一种甲磺酸奥希替尼的工艺杂质, 可用于非小细胞肺癌的研究。 | |||
T19858 |
Brodimoprim
|
DHFR; Antibacterial | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Brodimoprim 是甲氧苄啶的一种类似物,是口服有效的二氢叶酸还原酶抑制剂,对广谱革兰氏阴性和革兰氏阳性细菌具有高度的抑制作用。 | |||
T15391 |
Glufosinate ammonium
|
Others | Others |
Glufosinate ammonium 是谷氨酸的一种膦酸类似物,是一种除草剂,在植物细胞中转化为 PT (L-phosphinothricin) 。Glufosinate ammonium 显示出神经毒性作用。 | |||
TP2315 |
glatiramer Acetate
|
Others | Others |
Glatiramer acetate 是髓鞘碱性蛋白的合成类似物和免疫调节剂,可用于多发性硬化症的研究。它能够诱导 T 辅助细胞 2 的特异性抑制细胞迁移到大脑并导致原位旁观者抑制。它能够于 MHC 分子强而杂乱的结合,因此与各种髓鞘抗原竞争,使其呈现给 T 细胞。 | |||
T38240 |
2,6-Dichlorodiphenylamine
|
Antibacterial | Microbiology/Virology |
2,6-Dichlorodiphenylamine 是双氯芬酸钠的一种结构类似物,显示出抗白色念珠菌活性。2,6-Dichlorodiphenylamine 是非选择性抗炎剂,为COX 的抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的IC50分别为 4 和 1.3 nM。 | |||
T7736 |
2-Chloroadenosine
|
Adenosine Receptor | GPCR/G Protein; Neuroscience |
2-Chloroadenosine 是腺苷类似物,可防止大鼠海马缺血细胞长期丢失。它是尿苷内流 (Ki:33 μM) 的竞争性抑制剂,高亲和力与硝基苄基硫肌苷结合 (Ki:0.18 mM)。它是一种人红细胞核苷转运体的转运渗透剂。 | |||
T9162 |
CID1231538
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
CID1231538 是一种苯并噻唑类似物,是 GPR35拮抗剂。其中 GPR35 是一种 G 蛋白偶联受体 (GPCR)。 | |||
TNU0045 | β-D-Ribofuranose analogue 1 | ||
Nucleoside Derivatives - 5-Modified pyrimidine nucleosides; Thio-nucleosides; Amino nucleosides; Protected nucleosides w/NH2/OH open | |||
T41248 |
Thiocolchicine
|
Microtubule Associated | Cytoskeletal Signaling |
Thiocolchicine 是一种有效的微管蛋白聚合抑制剂,IC50 为 2.5 µM,Ki 为 0.7 µM。 Thiocolchicine 诱导细胞凋亡。 Thiocolchicine 可用作 ADC 技术中的 ADC 细胞毒素。 | |||
T9744 | MP07-66 | Phosphatase | Metabolism |
MP07-66 是 FTY720 的一种类似物,没有免疫抑制作用。MP07-66通过破坏 SET-PP2A 复合物导致PP2A 重新激活。MP07-66在慢性淋巴细胞白血病中显示出良好的抗肿瘤作用。 | |||
T0297 |
Clofarabine
Clofarex,氯法拉滨,克罗拉滨,Evoltra,Clolar |
Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Clofarabine (Clofarex) 是一种核糖核苷酸还原酶抑制剂,IC50值为65 nM。它是核苷类似物,可用于癌症研究。 | |||
T69840 |
MX106
|
||
MX106 is a survivin inhibitor which induces degradation of XIAP and/or cIAP1, and suppresses genotoxic NF-kappaB activation. | |||
T15588 |
Iobenguane sulfate
硫酸碘苄胍 EP标准品,MIBG sulfate |
Others | Others |
Iobenguane sulfate (MIBG sulfate) 是一种具有抗肿瘤活性的神经递质去甲肾上腺素的类似物。Iobenguane sulfate 是一种高亲和力的霍乱毒素底物,干扰细胞单核(ADP-核糖基化)。放射性碘代 Iobenguane sulfate 可用于肾上腺肿瘤诊断和肿瘤靶向药物的研究。 | |||
T1162 |
Acipimox
Olbemox,K-9321,阿西莫司,阿昔莫司 |
Others | Others |
Acipimox (K-9321) 是烟酸类似物,能够急性抑制脂解作用,抑制全身游离脂肪水平,改善胰岛素敏感性。 | |||
T4993 |
Afloqualone
氟喹酮,HQ-495 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Afloqualone (HQ-495) 是一种 GABA 受体激动剂。靶点:体外 GABA 受体:Afloqualone 是一种喹唑啉酮家族 GABA 能药物。由于其在 GABAa 受体β亚型的激动剂活性,它具有镇静和肌肉松弛作用。 | |||
T1675 |
Adefovir dipivoxil
Hepsera,GS 0840,阿德福韦酯,Preveon |
Others; HBV; Reverse Transcriptase | Microbiology/Virology; Others |
Adefovir dipivoxil (GS 0840) 是一种腺苷类似物,是核苷逆转录酶抑制剂 Adefovir 的口服前药,具有抗乙型肝炎病毒、疱疹病毒和人类免疫缺陷病毒的活性。 | |||
T1646 |
Famciclovir
泛昔洛韦,BRL 42810 |
DNA/RNA Synthesis; HSV | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Famciclovir (BRL 42810) 是一种单纯疱疹病毒核苷类似物 DNA 聚合酶抑制剂。 | |||
T23213 |
QX-222 chloride
QX 222,Lidocaine N-Methyl Hydrochloride |
Sodium Channel | Membrane transporter/Ion channel |
QX-222 chloride (Lidocaine N-Methyl Hydrochloride) 是 Lignocaine 的一种三甲基类似物,是有效的 Na+通道阻滞剂。 | |||
T0863 |
Idoxuridine
IDU,碘苷,SKF 14287,5-Iodo-2′-deoxyuridine,NSC 39661,5-IUdR,Dendrid |
Antifection; HSV | Microbiology/Virology |
Idoxuridine (Dendrid) 是一种抑制病毒 DNA 合成的脱氧尿苷类似物,用作抗病毒剂。 | |||
T2641 |
KRCA-0008
KRCA 0008,KRCA0008 |
ACK; ALK | Angiogenesis; Tyrosine Kinase/Adaptors |
KRCA-0008 是高效的、选择性的 ALK/Ack1 抑制剂,对ALK 和Ack1的IC50值分别为12nM 和4nM,显示出非hERG 依赖性药物活性。 | |||
T1404 |
Stavudine
d4T,Sanilvudine,BMY-27857,NSC 163661,司他夫定 |
Apoptosis; Nucleoside Antimetabolite/Analog; HIV Protease; NOD-like Receptor (NLR); Reverse Transcriptase; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Stavudine (BMY-27857) 是一种口服活性核苷逆转录酶抑制剂,还抑制线粒体 DNA 的复制,具有抗HIV-1和HIV-2的活性。它降低 NLRP3 炎症小体激活,调节淀粉样 β 自噬,诱导细胞凋亡。 | |||
T5882 |
3-Bromopyruvic acid
Hexokinase II Inhibitor II, 3-BP,3-溴丙酮酸,Bromopyruvic acid |
Apoptosis; Hexokinase; Autophagy | Apoptosis; Autophagy; Metabolism |
3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) 是己糖激酶 II 抑制剂,是针对肝癌细胞的一种抗肿瘤剂。 | |||
T1038 |
Fludarabine
NSC 118218,Fludarabinum,氟达拉宾,氟达拉滨,F-ara-A |
Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; STAT | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; JAK/STAT signaling; Stem Cells |
Fludarabine (Fludarabinum) 是一种氟化嘌呤类似物,一种核酸合成抑制剂和 STAT1 激活抑制剂。Fludarabine 具有抗肿瘤活性,可以用于治疗白血病和淋巴瘤。 | |||
T14489 |
Azvudine
4-氨基-1-(4-C-叠氮基-2-脱氧-2-氟-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮,FNC,RO-0622 |
HCV Protease; HBV; HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Azvudine (FNC) 是一种有效的核苷逆转录酶抑制剂 (NRTI),对 HIV、HBV 和 HCV 具有抗病毒活性。它抑制耐 NRTI 的病毒株,高效抑制 HIV-1和 HIV-2。 | |||
T60103 |
N6-(p-Hydroxyphenethyl)-Adenosine)
|
Others | Others |
N6-(p-Hydroxyphenethyl)-Adenosine) 是一种腺苷类似物。 | |||
T25130 |
Azaribine
NSC 67239 |
||
Azaribine, a pyrimidine analogue, is an anti-metabolite utilized in psoriasis and mycosis fungoides. | |||
T13718 |
H-Arg(Pbf)-OMe hydrochloride
|
Others | Others |
H-Arg(Pbf)-OMe hydrochloride 是一种精氨酸类似物。 | |||
T10858 | COH34 analog 1 | Others | Others |
COH34 analog 1 是一种 COH34 氧化类似物,可用于合成具有活性的化合物。 | |||
T6507 |
Gabapentin hydrochloride
加巴喷丁盐酸盐,Neurontin HCl,Gabapentin HCl |
Calcium Channel; GABA Receptor | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Gabapentin hydrochloride (Neurontin HCl) 是GABA 类似物,可用于缓解神经性疼痛。 | |||
T32826 |
LNA-Adenosine
LNA-A,LNA Adenosine,2'-O,4'-C-Methyleneadenosine |
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
LNA-Adenosine (LNA-A) 是一种核苷类似物,可作为作为腺苷A3受体配体。 | |||
T61214 |
EWP 815
|
Phosphatase; Hydroxylase | Metabolism |
EWP 815 is a disulfiram analogue that functions as a powerful inhibitor of Ins(1,4) P 2 phosphatase, Ins(1,4,5) P 3 5-phosphatase, and dopamine β-hydroxylase activity [1] [2]. | |||
T7398 |
ONC212
|
Apoptosis; GPR | Apoptosis; Endocrinology/Hormones; GPCR/G Protein |
ONC212 是氟化 ONC201 类似物,是有前景的抗癌剂。它也是 GPR132的选择性激动剂,可诱导凋亡。 | |||
T0445 |
Promethazine
Proazamine,异丙嗪,Diphergan |
CaMK; Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Promethazine (Proazamine) 是抗青光眼前列腺素(PG)的类似物。 | |||
TP2052L |
CTOP acetate
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
CTOP acetate 是一种生长抑素类似物和μ-阿片受体拮抗剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T81993 |
Kadsurin A analogue-1
|
||
Kadsurin A analogue-1 (Compound 8) 为源自Piper argyrophylum的木脂素类化合物。 | |||
T14865 |
Carboprost tromethamine
|
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Carboprost tromethamine 是合成的前列腺素 F2α的15-甲基类似物,能有效促进子宫的规律收缩,显着减少产中及产后出血量。 | |||
T2O2707 |
D-(+)-Fucose
|
Others | Others |
D-(+)-Fucose 是一种 l-阿拉伯糖的非代谢类似物,也是 β-甲基半乳糖苷透皮酶诱导剂。它能够抑制 l-阿拉伯糖操纵子的诱导,阻断大肠杆菌 B/r 在矿物盐培养基上加 l-阿拉伯糖的生长。 | |||
T7992 |
4-Hydroxyflavanone
|
NO Synthase | Immunology/Inflammation |
4-Hydroxyflavanone 是一种黄酮的合成类似物,是 SREBP 成熟和脂质合成的抑制剂。它具有研究肝脏脂肪变性及血脂异常的潜力。 | |||
T3843 |
Pinosylvin
银松素,3,5-stilbenediol,5-Styrylresorcinol |
Apoptosis; Others; Antibacterial; Autophagy | Apoptosis; Autophagy; Microbiology/Virology; Others |
Pinosylvin (5-Styrylresorcinol) 是从Pinus spp 的心材中分离出来的一种白藜芦醇类似物,可诱导白血病细胞凋亡和自噬。它是一种感染前的类苯乙烯类毒素,具有抗菌活性。 | |||
T13495 |
3-Amino-2-piperidinone
Cyclo-ornithine |
Endogenous Metabolite | Metabolism |
3-Amino-2-piperidinone 是来自生物体的代谢物,可用作环状鸟氨酸类似物。 | |||
T13555 |
Ascr#2
Ascaroside C6 |
Others | Others |
Ascr#2 (asc-C6-MK)是秀丽隐杆线虫中的糖苷类化合物,促进 dauer 形成。Ascr#2 在低浓度下与 ascr#3 的混合物可作为雄性引诱剂,可用于检测种群密度。 | |||
T13750 |
L-Fucitol
L-岩藻糖醇,1-Deoxy-D-galactitol |
Others | Others |
L-Fucitol (1-Deoxy-D-galactitol) 是一种糖醇,从肉豆蔻 (Nutmeg) 中分离得到。 | |||
T7849 |
Norspermine
|
Others | Others |
Norspermine 是一种多胺类似物,用于治疗非小细胞肺癌和乳腺癌。 | |||
T13557 |
Ascr#5
Ascaroside C3 |
Others | Others |
Ascr#5 (asc-ωC3)是秀丽隐杆线虫中高度保守的蛔苷类物质,可调节秀丽隐杆线虫的多种反应。 | |||
T8084 |
Dimethyl 4-hydroxyisophthalate
二甲基 4-羟基异邻苯二甲酸酯,Dimetghyl 4-Hydroxyisophthalate |
Others | Others |
Dimethyl 4-hydroxyisophthalate (Dimetghyl 4-Hydroxyisophthalate) 是水杨酸甲酯类似物。 | |||
T2218 |
8-Azaguanine
Azaguanine-8,SK 1150,8-氮鸟嘌呤,NSC-749,SF-337 |
Nucleoside Antimetabolite/Analog; Others; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others |
8-Azaguanine (SK 1150) 是一种具有潜在抗肿瘤活性的嘌呤类似物。它易于掺入核糖核酸中,干扰正常的生物合成途径,从而抑制细胞生长,可作为抗代谢药。 | |||
T6004 |
Tetrahydropapaverine hydrochloride
Tetrahydropapaverine HCl,Norlaudanosine HCl,Tetrahydroalkali hydrochloride,四氢罂粟碱盐酸盐 |
Hydroxylase | Metabolism |
Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) 是一种四氢异喹啉类药物。它对多巴胺神经元有神经毒性作用。 | |||
TN6928 |
L-Azetidine-2-carboxylic acid
(2S)-azetidine-2-carboxylic acid,(S)-(-)-2-羧基环丁胺 |
Endogenous Metabolite | Metabolism |
L-Azetidine-2-carboxylic acid ((2S)-azetidine-2-carboxylic acid) 是内源性代谢产物的一种。 | |||
TN2175 |
Salvianolic acid F
丹酚酸F,丹酚酸 F |
Caspase | Apoptosis; Proteases/Proteasome |
The role of our hybrid molecules, an analogue of Salvianolic acid F, in compelling the glioma cells towards apoptosis by specifically perturbing the concentration of glutathione along with caspase 6. | |||
T40569 |
Hygric acid
N-Methyl-L-proline,古液酸;古柯叶液碱酸 |
Others | Others |
Hygric acid (N-Methyl-L-proline) 是脯氨酸的一种类似物,存在于柑橘汁和佛手柑汁中。 | |||
T4S1848 |
Tubeimoside II
Tubeimoside-B,土贝母苷乙 |
Others | Others |
Tubeimoside II (Tubeimoside-B) 是一种齐墩果烷型三萜皂甙天然类似物,具有抗炎症和抗癌等生物特性。 | |||
T32832 |
Lobelanidine
NSC-95097,8,10-Diphenyllobelidiol,NSC 95097,NSC95097 |
AChR | Neuroscience |
Lobelanidine (8,10-Diphenyllobelidiol) 是可从 Lobelia chinensis Lour 和 Lobelia tupa 的地上部分中提取得到,是 lobeline 的类似物,对 nAChR 表现出适度的亲和力。 | |||
T1059 |
Retinyl palmitate
Retinol palmitate,Vitamin A palmitate,Retinyl (Vitamin A) Palmitate,维生素A棕榈酸酯 |
Others; Endogenous Metabolite | Metabolism; Others |
Retinyl palmitate (Vitamin A palmitate) 是酯化的视黄醇,是表皮中维生素 A 的主要形式,在药品和化妆品中有广泛应用。 | |||
T7004 |
Tubercidin
结核菌素,杀结核菌素,Sparsomycin A,7-Deazaadenosine |
Influenza Virus; DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Tubercidin (Sparsomycin A) 是从Streptomyces tubercidicus 得到的抗生素,抑制粪链球菌生长的IC50值为 0.02 μM。它是腺苷磷酸化酶的弱抑制剂,并干扰腺苷和 AMP 的磷酸化。它有抗病毒作用。 | |||
T3S1960 |
Kakuol
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Antifungal | Microbiology/Virology |
Kakuol 是一种有抗真菌活性的天然产物。 | |||
T11060 |
DMAPT
Dimethylamino Parthenolide |
NF-κB | NF-κB |
DMAPT (Dimethylamino Parthenolide) 是一种具有口服活性的NF-κB 抑制剂,是一种 Parthenolide (PTL) 的类似物,对原发性急性髓性白血病细胞的LD50值为1.7 μM。具有潜在的抗肿瘤和抗转移作用。 | |||
T7056 |
Dronedarone
决奈达隆,SR 33589 |
P450; Potassium Channel; Calcium Channel; Sodium Channel; Adrenergic Receptor; AChR; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Dronedarone (SR 33589) 是一种胺碘酮类似物,对治疗心房颤动可能有效。它是CYP3A4的底物和中度抑制剂。它是多种离子电流的有效阻滞剂,通过非竞争性结合到肾上腺素能受体显示出抗肾上腺素能的效果。 | |||
T4513 |
Vanillyl butyl ether
4-(Butoxymethyl)-2-methoxyphenol,香兰醇丁醚,Butyl vanillyl ether,香草醇丁醚 |
Others | Others |
Vanillyl butyl ether (Butyl vanillyl ether) 是香草特有风味和香气的来源。它是辣椒素类似物,对人体有感官刺激作用。它是环保且无毒的物质。它是烷氧基取代的苄基衍生物,主要用作调味剂。 | |||
TL0009 |
coniferin
Coniferoside,松柏苷,Abietin |
Others; Antifungal | Microbiology/Virology; Others |
Coniferin (Abietin) 是一种松柏醇中的葡萄糖苷。它抑制真菌生长和黑化反应,具有 ATP 依赖性转运活性并具有抗氧化作用。 | |||
T1658 |
Selenomethionine
DL-Selenomethionine,DL-硒代蛋氨酸,Seleno-DL-methionine,硒代蛋氨酸 |
Amino Acids and Derivatives; Endogenous Metabolite; Autophagy | Autophagy; Metabolism |
Selenomethionine (Seleno-DL-methionine) 是一种硒代氨基酸,是蛋氨酸的硒类似物。 它具有作为植物代谢物的作用。 它是硒代蛋氨酸和硒代氨基酸的成员。 | |||
T30969 |
Clitocine
|
Apoptosis; BCL | Apoptosis |
Clitocine 是一种来从蘑菇中提取的一种腺苷类似物,是一种有效的转录通读剂,是一种无义突变的抑制剂,具有抗癌活性,可诱导携带 p53 无义突变等位基因的细胞产生 p53 蛋白。Clitocine 通过促进 Mcl-1 降解来增强 TRAIL 介导的人结肠癌细胞凋亡。 | |||
T2S2382 |
3'-Hydroxypterostilbene
3’-羟基紫檀茋,3'-羟基紫檀茋,3'-HPT |
Apoptosis; Autophagy | Apoptosis; Autophagy |
3'-Hydroxypterostilbene (3'-HPT) 是天然紫檀芪类似物,通过诱导细胞凋亡和自噬,有效抑制人结肠癌细胞的生长。它抑制 PI3K/Akt/mTOR/p70S6K 和 p38MAPK 途径并激活 ERK1/2,JNK1/2 MAPK 途径。 | |||
T1437 |
D-Panthenol
D-泛醇,D-Pantothenyl alcohol,Ilopan,Dexpanthenol,Pantothenol |
Endogenous Metabolite | Metabolism |
D-Panthenol (D-Pantothenyl alcohol) 是 D-pantothenic acid 和胆碱能剂的酒精类似物。D-Panthenol 作为乙酰化反应所必需的辅酶A的前体,参与乙酰胆碱的合成。虽然 D-Panthenol 作用的确切机制尚不清楚,但它可能增强乙酰胆碱的作用。D-Panthenol 作用于胃肠道,增加下肠蠕动。它也适用于局部皮肤,以缓解瘙痒和促进愈合。 | |||
T38479 |
3-Hydroxypyridine
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3-Hydroxypyridine, extracted from Bamboo grass, is a structural analogue of vitamin B6. It exhibits diverse pharmacological properties, including antioxidant activity. | |||
T40657 |
Epiquinidine
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Epiquinidine, a quinine analogue, can be used as the ggTas2r1 agonist. Epiquinidine activates ggTas2r1 at or beyond 10 μM. | |||
T16673 |
Pseudouridimycin
PUM |
Others | Others |
Pseudouridimycin is a C-nucleoside analogue. Pseudouridimycin is an antibiotic and is a selective bacterial RNA polymerase (RNAP) inhibitor. It is effective against both Gram-negative and Gram-positive bacteria. | |||
T83235 |
8-C-Glucosyl-(R)-aloesol
(R)-Aloesinol |
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8-C-Glucosyl-(R)-aloesinol((R)-aloesinol)系一种活性色素类似物。 | |||
TN2287 |
Turkesterone
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Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Turkesterone is a phytoecdysteroid possessing an 11alpha-hydroxyl group, also is an analogue of the insect steroid hormone 20-hydroxyecdysone. It has immunomodulating and antistress activity, can increase the adaptation capacity of mice under immobilization-induced stress conditions. | |||
T79988 |
Cytochalasin R
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Cytochalasin R (compound 17)是从内生真菌拟茎点霉菌sp. xz-18中提取的一种Cytochalasin类似物,表现出潜在的抗真菌活性。 | |||
T40483 |
8-Aminoadenosine
8-NH2-Ado,8-氨基腺苷 |
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8-Aminoadenosine (8-NH2-Ado) is an RNA-directed nucleoside analogue that effectively diminishes cellular ATP levels and impedes mRNA synthesis. Furthermore, it effectively obstructs Akt/mTOR signaling, inducing autophagy and apoptosis in a p53-independent manner. Its significant antitumor activity further highlights its therapeutic potential. | |||
T39071 | Thailanstatin D | ||
Thailanstatin D, an analogue of Thailanstatin A, inhibits AR-V7 gene splicing by disrupting the interaction between U2AF65 and SAP155, hindering their binding to the polypyrimidine tract situated between the branch point and the 3' splice site. This compound displays potent tumor inhibitory properties in human castration-resistant prostate cancer (CRPC) xenografts, resulting in cellular apoptosis. | |||
T75692 | Hypoglaunine D | ||
Hypoglaunine D 是 Triptonine B 的类似物,是一种抗HIV 的化合物,Hypoglaunine D 抑制 H9 淋巴细胞中HIV 病毒复制的EC50值为 22 μg/ml。 | |||
T83331 |
4,5-Dihydroxy-2-((5-methyl-3,8-dimethylene-2-oxododecahydroazuleno[6,5-b]furan-5-yl)oxy)tetrahydro-2H-pyran-3-yl acetate
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4,5-Dihydroxy-2-((5-methyl-3,8-dimethylene-2-oxododecahydroazuleno[6,5-b]furan-5-yl)oxy)tetrahydro-2H-pyran-3-yl acetate,一种α-阿拉伯吡喃糖的类似物,可从大麦地上部分提取。 | |||
T83437 |
18-O-Demethylpederin
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18-O-Demethylpederin 是 pederin 的一种类似物,原先自隐翅虫科昆虫中分离得到。作为一种天然聚酮化合物,pederin 是非蛋白质昆虫毒素,展现了包含抗菌、抗病毒和抗肿瘤在内的广泛生物活性。 | |||
T83319 |
4-epi-Withaferin A
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4-epi-Withaferin A(化合物28)是Withaferin A的一个类似物,它增强了细胞毒性及细胞保护性热休克诱导活性(HSA)。此外,4-epi-Withaferin A还展现了通过激活细胞防御机制来研究蛋白质聚集相关疾病的潜力。 | |||
T82032 |
Isoglobotriaose
Gala-3Galb-4Glc |
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Isoglobotriaose (Gala-3Galb-4Glc)是哺乳动物组织中的一种糖鞘脂,属于球状三脂糖的类似物。其神经节苷脂衍生物isoglobotriaosylceramide特定分布于小肠非上皮细胞的残基中,而globotriaosylceramide则在两种细胞隔室中都有分布。 | |||
T81201 |
Sartorypyrone B
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Sartorypyrone B为Chevalone C的2β-乙酰氧基衍生物,由海绵源真菌Neosartorya tsunodae(KUFC 9213)的培养物中乙酸乙酯提取得到。该化合物对MCF-7、NCI-H460和A375-C5细胞系展示出较强的生长抑制活性,GI50s值分别为17.8、20.5和25.0 μM,显示其在乳腺癌、非小细胞肺癌和黑色素瘤研究中的应用潜力。 |