Name: Taltobulin hydrochloride (228266-40-8 free base)
Brand: TargetMol
SKU: T13073L
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 24,900

3-6月

50 mg

¥ 33,300

3-6月

100 mg

¥ 43,500

3-6月

生物活性

产品描述	Taltobulin hydrochloride is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
体外活性	The growth of 18 tumor cell lines (leukemia, ovarian, NSCLC, breast, colon, and melanoma cell lines) inhibited by Taltobulin (HTI-286; 0.2-7.3 nM; 3 days)(with an average IC50 of 2.5±2.1 nM and a median value of 1.7 nM).
体内活性	In athymic nu/nu female mice, Taltobulin (HTI-286; 1.6 mg/kg i.v.) inhibits the growth of human tumor xenografts (e.g., HCT-15, DLD-1, MX-1W, and KB-8-5) . Taltobulin (HTI-286; 3 mg/kg; p.o. gavage) inhibits growth by 97.3 % and 82% in athymic nu/nu female mice with Lox melanoma xenografts and KB-3-1 epidermoid xenograft model, respectively.
别名	Taltobulin hydrochloride, SPA-110 hydrochloride, HTI-286 hydrochloride

化学信息

分子量	510.11
分子式	C₂₇H₄₄ClN₃O₄
Smiles	CC(C)(C)[C@H](NC([C@H](C(C)(C1=CC=CC=C1)C)NC)=O)C(N([C@@H](C(C)C)/C=C(C(O)=O)\C)C)=O.Cl[H]
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 100 mg/mL (196.04 mM), Sonication is recommended.

溶液配制表

DMSO

Taltobulin hydrochloride (228266-40-8 free base)