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顶部生物活性储存和溶解信息计算器参考文献文献引用

DOTMA

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DOTMA
产品编号 T8902Cas号 104872-42-6
别名 Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride, N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium

DOTMA (N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium) 作为 tetra-methylated DOTA 类似物，是一种阳离子脂类，被用作基因治疗的非病毒载体。它已被用作脂质体的成分，可用于封装 siRNA、microRNA 和寡核苷酸，并用于体外基因转染。在体外和体内均表现出良好的基因转染效果。DOTMA 诱导脂质体上的正电荷，从而促进脂质体与细胞膜的有效相互作用。

DOTMA
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DOTMA

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DOTMA
纯度: 98.22%
产品编号 T8902 别名 Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride, N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammoniumCas号 104872-42-6

DOTMA (N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium) 作为 tetra-methylated DOTA 类似物，是一种阳离子脂类，被用作基因治疗的非病毒载体。它已被用作脂质体的成分，可用于封装 siRNA、microRNA 和寡核苷酸，并用于体外基因转染。在体外和体内均表现出良好的基因转染效果。DOTMA 诱导脂质体上的正电荷，从而促进脂质体与细胞膜的有效相互作用。

规格价格库存数量
1 mg
¥ 258
现货
5 mg
¥ 593
现货
10 mg
¥ 889
现货
25 mg
¥ 1,490
现货
50 mg
¥ 1,980
现货
100 mg
¥ 2,880
现货
200 mg
¥ 4,130
5日内发货
1 mL x 10 mM (in DMSO)
¥ 832
现货
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TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
实验操作小课堂
常见问题解答
问化合物带有盐酸盐离子、硫酸盐离子等是否和其本身有什么区别？盐形式和游离态有什么区别？
答盐和非盐形式化合物的活性分子是一样的，在生物实验中起到的效果也一致，活性和使用方法都是一样的。只是由于呈盐不同，物理性质比如溶解度会有差异。建议您根据溶解、实验需求进行选择。
问如何选择某个靶点的特异性或总的抑制剂？特异性和非特异性的区别是什么？
答抑制剂按照特异性分为广谱 pan 和特异性 selective 两种。Pan 为某个靶点总的抑制剂，对所有亚型或整个家族的成员都有抑制作用。Selective 抑制剂针对某个蛋白激酶的某个亚型或家族中某个成员抑制率特别高或有特异性抑制作用。 一般评价一个抑制剂的抑制效率主要看 IC50 值，IC50 值越低，说明抑制剂效率越高。建议您根据以上几个特征进行综合选择，也可联系技术帮您推荐相关抑制剂。
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纯度:98.22%
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DataSheet SDS COA HNMR HPLC LCMS产品操作手册

产品介绍

生物活性
产品描述
DOTMA (N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium) is a tetra-methylated DOTA analogue. DOTMA is a cationic lipid and can be used as a non-viral vector for gene therapy. It has been used as a component in liposomes that can be used to encapsulate siRNA, microRNAs, and oligonucleotides and for gene transfection in vitro. It exhibits effective in vitro and in vivo gene transfection. DOTMA induces a positive charge on the liposomes and thus promotes efficient liposome- cell membrane interaction.
别名Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride, N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium
化学信息
分子量670.58
分子式C42H84ClNO2
CAS No.104872-42-6
Smiles[Cl-].CCCCCCCC\C=C\CCCCCCCCOCC(C[N+](C)(C)C)OCCCCCCCC\C=C\CCCCCCCC
密度no data available
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
DMSO: 45 mg/mL (67.1 mM), Sonication and heating to 60℃ are recommended.
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM1.4912 mL7.4562 mL14.9125 mL74.5623 mL
5 mM0.2982 mL1.4912 mL2.9825 mL14.9125 mL
10 mM0.1491 mL0.7456 mL1.4912 mL7.4562 mL
20 mM0.0746 mL0.3728 mL0.7456 mL3.7281 mL
50 mM0.0298 mL0.1491 mL0.2982 mL1.4912 mL

SCI 文献

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments 一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为 2 mg/mL 。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

参考文献

1.Srivastava S, et al. Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis. Sci Rep. 2016 Apr 12;6:24049.2.Hashemzaei M, et al. Anticancer and apoptosis‑inducing effects of quercetin in vitro and in vivo. Oncol Rep. 2017 Aug;38(2):819-828.3.Lan H, et al. Quercetin Inhibits Cell Migration and Invasion in Human Osteosarcoma Cells. Cell Physiol Biochem. 2017;43(2):553-567.4.Liu H, et al. Effect of quercetin on the anti-tumor activity of cisplatin in EMT6 breast tumor-bearing mice. Obstet Gynecol Sci. 2019 Jul;62(4):242-248.5.Islam MT, et al. Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age. Aging Cell. 2023 Feb;22(2):e13767.6.Liang Y, Xu Z, Wu X, et al. Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels with natural flavonoid quercetin[J]. Biochemical and Biophysical Research Communications. 20207.Shim K S, Hwang Y H, Jang S A, et al. . Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice[J]. Nutrients.  2020, 12(7): 1927.8.Peng D, Chen L, Sun Y, et al. Melanoma suppression by quercein is correlated with RIG-I and type I interferon signaling[J]. Biomedicine & pharmacotherapy= Biomedecine & pharmacotherapie. 2020, 125: 109984.

文献引用

1.Guo C R, Zhang Z Z, Zhou X, et al.Chronic cough relief by allosteric modulation of P2X3 without taste disturbance.Nature Communications.2023, 14(1): 5844.2.Zhang Z, Shi J, Wu Q, et al.JUN mediates Glucocorticoid Resistance by stabilizing HIF1a in T-Cell Acute Lymphoblastic Leukemia.iScience.20233.Shan H, Zhang X, Mi Y, et al.Eriodictyol Suppresses Gastric Cancer Cells via Inhibition of PI3K/AKT Pathway.Pharmaceuticals.2022, 15(12): 1477.4.Gul H, Ali R, Rauf M, et al.Aspergillus welwitschiae BK Isolate Ameliorates the Physicochemical Characteristics and Mineral Profile of Maize under Salt Stress.Plants.2023, 12(8): 1703.5.Li S, Hao L, Hu X, et al.A systematic study on the treatment of hepatitis B-related hepatocellular carcinoma with drugs based on bioinformatics and key target reverse network pharmacology and experimental verification.Infectious Agents and Cancer.2023, 18(1): 41.6.Qadir M, Hussain A, Hamayun M, et al. Phytohormones Producing Acinetobacter bouvetii P1 Mitigates Chromate Stress in Sunflower by Provoking Host Antioxidant Response. Antioxidants. 2021, 10(12): 1868.7.Peng D, Chen L, Sun Y, et al. Melanoma suppression by quercein is correlated with RIG-I and type I interferon signaling. Biomedicine & Pharmacotherapy. 2020, 125: 1099848.Shan H, Zhang X, Mi Y, et al.Eriodictyol Suppresses Gastric Cancer Cells via Inhibition of PI3K/AKT Pathway.Pharmaceuticals.2022, 15(12): 1477.9.Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet. Planta Medica. 2019, 85(14/15): 1128-113510.Liang Y, Xu Z, Wu X, et al. Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels with natural flavonoid quercetin. Biochemical and Biophysical Research Communications. 202011.Jang S A, Hwang Y H, Yang H, et al. Ethanolic extract of Pyrrosia lingua (Thunb.) Farw. ameliorates OVX-induced bone loss and RANKL-induced osteoclastogenesis. Biomedicine & Pharmacotherapy. 2022, 147: 112640.12.Shim K S, Hwang Y H, Jang S A, et al.  Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice. Nutrients. 2020, 12(7): 192713.Zhu L, Liu R, Liu T, et al. A novel strategy to screen inhibitors of multiple aminoglycoside-modifying enzymes with ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2019, 164: 520-52714.Shim K S, Hwang Y H, Jang S A, et al. Ethanol Extract of Amomum tsao-ko Ameliorates Ovariectomy-Induced Trabecular Loss and Fat Accumulation. Molecules. 2021 Feb 3;26(4):784.15.Zhang Y, Yu F, Hao J, et al. Study on the Effective Material Basis and Mechanism of Traditional Chinese Medicine Prescription (QJC) Against Stress Diarrhea in Mice. Frontiers in Veterinary Science. 2021, 8.16.Lee S J, Yang H, Kim S C, et al.Ethanol Extract of Radix Asteris Suppresses Osteoclast Differentiation and Alleviates Osteoporosis.International Journal of Molecular Sciences.2023, 24(22): 16526.17.Peng C, Ai Q, Zhao F, et al.Quercetin attenuates cerebral ischemic injury by inhibiting ferroptosis via Nrf2/HO-1 signaling pathway.European Journal of Pharmacology.2023: 176264.18.Wang T, Yang C, Li Z, et al.Flavonoid 4, 4′-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy.Redox Biology.2023: 103017.19.Hao L, Li S, Chen G, et al.Study on the mechanism of quercetin in Sini Decoction Plus Ginseng Soup to inhibit liver cancer and HBV virus replication through CDK1.Chemical Biology & Drug Design.2024, 103(6): e14567.20.Kim K Y, Kang Y M, Lee A, et al.Hydroethanolic Extract of Lepidium apetalum Willdenow Alleviates Dextran Sulfate Sodium-Induced Colitis by Enhancing Intestinal Barrier Integrity and Inhibiting Oxidative Stress and Inflammasome Activation.Antioxidants.2024, 13(7): 795.21.Xiao C Y, Tang Y, Ren T, et al.Treatment of silicosis with quercetin depolarizing macrophages via inhibition of mitochondrial damage-associated pyroptosis.Ecotoxicology and Environmental Safety.2024, 286: 117161.22.Cheng M, Yan X, Wu Y, et al.Qingke Pingchuan granules alleviate airway inflammation in COPD exacerbation by inhibiting neutrophil extracellular traps in mice.Phytomedicine.2024: 156283.23.Peng C, Li H, Mao Q, et al.Quercetin inhibits hydrogen peroxide-induced cleavage of heat shock protein 90 to prevent glutathione peroxidase 4 degradation via chaperone-mediated autophagy.Phytomedicine.2024: 156286.24.Long B, Zhou H, Xiao L, et al.Targeting NUF2 suppresses gastric cancer progression through G2/M phase arrest and apoptosis induction.Chinese Medical Journal.2024: 10.1097.

关键词

DOTMACationic Lipid

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