81
9
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12153 |
N-type calcium channel blocker-1
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
N-type calcium channel blocker-1 is an orally active analgesic agent,shows high affinity to functionally block N-type calcium channels. | |||
TQ0155 |
Miglustat hydrochloride
NB-DNJ hydrochloride,盐酸美格鲁特,N-Butyldeoxynojirimycin hydrochloride,OGT918 hydrochloride |
Transferase | Metabolism |
Miglustat hydrochloride (N-Butyldeoxynojirimycin hydrochloride) 是一种葡萄糖神经酰胺合酶抑制剂,可用于 I 型戈谢病的相关研究。 | |||
T12302 |
OMDM-1
(Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide |
Endogenous Metabolite | Metabolism |
OMDM-1 ((Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide) 是有效选择性的代谢稳定 anandamide 细胞摄取抑制剂,Ki=为2.4 μM。 | |||
T21900 |
ML-336
(E)-2-((1,4-二甲基哌嗪-2-亚基)氨基)-5-硝基-N-苯基苯甲酰胺 |
Others | Others |
ML-336 是一种喹唑啉酮类的委内瑞拉马脑炎病毒 (VEEV) 抑制剂,其VEEV TC-83 CPE(IC50:32 nM)、VEEV V3526 CPE(IC50:20 nM)、VEEV 野生型 CPE (IC50:42 nM),有效抑制 VEEV 诱导的三种病毒株 (V3526、TC-83和野生型) 细胞病变效应。 | |||
TP1559L |
Ziconotide Acetate (107452-89-1 free base)
醋酸齐考诺肽,Prialt,Ziconotide Acetate |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Ziconotide Acetate (107452-89-1 free base) (Prialt) 是一种镇痛剂,已用于治疗神经性和非神经性疼痛。 Ziconotide 通过与位于伤害感受通路初级传入神经元末端部分的 N 型钙通道结合起作用,因此通过有效的镇痛作用减少突触传递。 | |||
T7334 |
NP118809
39-1B4,1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
NP118809 (39-1B4) 是 N 型钙通道阻滞剂,IC50值为 0.11 μM。它较弱地抑制 L 型钙通道,IC50值为 12.2 μM。 | |||
T11517 |
GV-58
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
GV-58 是选择性 N 型和 P/Q 型 Ca2+ 通道激动剂,EC50值分别为7.21和8.81uM。它对 CDK 激酶活性的抑制作用减少了 20 倍。 | |||
T10659 |
Ca2+ channel agonist 1
|
Calcium Channel; CDK | Cell Cycle/Checkpoint; Membrane transporter/Ion channel; Metabolism |
Ca2+channel agonist 1 是 N-型钙离子通道激动剂和Cdk2的抑制剂,EC50分别为 14.23 μM 和 3.34 μM,可用作运动神经末梢功能障碍的潜在治疗方法。 | |||
T4462 |
Roflumilast N-oxide
|
PDE | Metabolism |
Roflumilast N-oxide 是一种 PDE 4 型抑制剂。 | |||
T12385 |
PD0176078
PD176078 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
PD0176078 () 是一种新型的 N 型钙通道 (Calcium channel) 阻滞剂。 | |||
T10690 |
Cav 2.2 blocker 1
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Cav 2.2 blocker 1 是一种N 型钙离子通道 (Cav 2.2) 的阻断剂,IC50值为 1 nM,可用于治疗疼痛。 | |||
T36061 |
N-Desmethyl Sildenafil
Desmethylsildenafil,UK-103,320 |
Drug Metabolite | Metabolism |
N-Desmethyl Sildenafil (UK-103,320) (Desmethylsildenafil) 是Sildenafil的主要代谢物,是一种强效的磷酸二酯酶类型5(PDE5)抑制剂。 | |||
T16448 | PD173212 | Calcium Channel | Membrane transporter/Ion channel; Metabolism |
PD 173212是一种阻断 N-型电压敏感性钙通道 (N-type voltage sensitive calcium channel, Cav2.2)的阻滞剂。PD173212的腹腔注射给药(0.0017-1.7 μmol/kg)显著降低了2,4-二硝基苯磺酸(DNBS)诱导结肠炎小鼠的内脏超敏反应。 | |||
T0388 |
Cilnidipine
FRC-8653,西尼地平 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Cilnidipine (FRC-8653) 是二氢吡啶类Ca2+通道阻断剂,可作用于 L 和 N 型 Ca2+通道,具有抗高血压活性。 | |||
T16339 |
Norverapamil hydrochloride
(±)-Norverapamil hydrochloride,D591 hydrochloride,盐酸去甲维拉帕米 |
Calcium Channel; P-gp; Drug Metabolite | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Norverapamil hydrochloride (D591 hydrochloride) 是 Verapamil 的 N-去甲基代谢物,是 L 型钙通道阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。 | |||
T62769 |
Tribendimidine
|
AChR | Neuroscience |
Tribendimidine 是一种广谱的、口服具有活力的驱虫剂,也是一种 L 型烟碱乙酰胆碱受体 (nAChR) 激动剂。Tribendimidine 对 A. lumbricoides 和 N. americanus 具有极高的活性。 | |||
T16240 |
N,N'-Diacetyl-L-cystine
(Ac-Cys-OH)2,DiNAC |
Others | Others |
N,N'-Diacetyl-L-cystine (DiNAC) 是一种具有免疫调节特性的 N-乙酰基半胱氨酸的二硫二聚体。它在高脂血症兔中也具有抗动脉粥样硬化的作用。它是啮齿类动物中接触敏感/迟发型超敏反应的有效口服活性调节剂。 | |||
T16164 |
MY-5445
N-(3-chlorophenyl)-4-phenylphthalazin-1-amine |
PDE | Metabolism |
MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) 是特异性的 cGMP 磷酸二酯酶 PDE5抑制剂,其 Ki=1.3 μM。它是一种 ABCG2转运蛋白调节剂,具有抗增殖活性。它能抑制人血小板凝集。 | |||
T6611 |
NSC697923
2-[(4-methylphenyl)sulfonyl]-5-nitrofuran |
E1/E2/E3 Enzyme | Ubiquitination |
NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage ... | |||
T16345 |
NS13001
N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine,N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine |
Potassium Channel | Membrane transporter/Ion channel |
NS13001 (N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine) 是口服有效的 SK 通道选择性正向变构调节剂。NS13001 对 SK2 和 SK3 通道的 EC50分别为 1.8 μM 和 0.14 μM。NS13001 在脊髓小脑共济失调 2 型和其他小脑共济失调方面具有研究价值。 | |||
T1024 |
Roflumilast
罗氟司特,B9302-107,BYK 20869,APTA 2217,BY 217 |
PDE; RSV | Metabolism; Microbiology/Virology |
Roflumilast (APTA 2217) 是一种口服的长效 4 型磷酸二酯酶抑制剂 (PDE4),具有抗炎和潜在的抗肿瘤活性,作用于PDE4A1,PDEA4,PDEB1和PDEB2,IC50分别为 0.7,0.9,0.7 和 0.2 nM。 | |||
T3627 |
IQ-1S free acid
IQ-1,IQ-1S,IQ-1S (free acid) |
NF-κB; JNK | MAPK; NF-κB |
IQ-1S free acid (IQ-1S) 是 NF-κB/激活蛋白1 (AP-1) 抑制剂(IC50:2.3±0.41 μM)。它对 JNK1(Kd:240 nM)、JNK2(Kd:360 nM) 和 JNK3(Kd:100 nM)的都具有高的结合亲和力 。 | |||
T38854 |
sFTX-3.3
|
||
sFTX-3.3 is a calcium ion channel antagonist, exhibiting IC50 values of approximately 0.24 mM and 0.70 mM against P-type and N-type channels respectively. | |||
T71202 |
A-1048400
|
||
A-1048400 is a potent and selective N-type and T-type calcium channel blocker. | |||
T25924 |
PD-151307
PD 151307 |
||
PD-151307 is used as an N-type calcium channel blocker. | |||
T69592 |
ONO-2921
|
||
ONO-2921 is a Novel N-Type Ca Channel Blocker | |||
TP2087 |
ω-Agatoxin IVA
|
||
Selective blocker of P-type calcium channels (IC50 < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations. | |||
T28125 |
N-5984
N5984,KRP-204,KRP 204,KRP204 |
||
N-5984, a β3-adrenergic receptor agonist, is used potentially for the treatment of obesity, overactive bladder and type 2 diabetes. | |||
T75727 |
ω-Conotoxin GVIA TFA
|
||
ω-Conotoxin GVIA TFA 是一种 N 型钙通道 (Ca2+channel) 抑制剂。 | |||
TP2064 |
ω-Conotoxin MVIIC
|
||
Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels. | |||
T35717 |
N-desmethyl Rosiglitazone
|
||
N-desmethyl Rosiglitazone is a major metabolite of rosiglitazone , a potent and selective PPARγ ligand present in formulations that have been used to treat type 2 diabetes. Rosiglitazone is metabolized by the cytochrome P450 (CYP) isoform CYP2C8 to form N-desmethyl rosiglitazone. | |||
T75792 |
Huwentoxin XVI TFA
|
||
Huwentoxin XVI TFA,一种来自鸟蛛 Ornithoctonus huwena 的止痛剂,一种高度可逆和选择性的哺乳动物 N 型钙通道 (N-type calcium channel) (IC50约为 60 nM) 拮抗剂。Huwentoxin XVI TFA 对电压门控的 T 型钙通道,钾通道或钠通道没有影响。 | |||
T68807 |
Azelnidipine, (R)-
|
||
Azelnidipine, (R)-, is an L-type calcium channel blocker (CCB). Studies have shown that in patients with hypertension (HT) and heart failure preserved ejection fraction (HFpEF), azelnidipine improved the severity of HF and cardiac sympathetic nerve activity compared with cilnidipine, an N-type CCB (Cat#326734). | |||
T80496 |
Kurtoxin
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Kurtoxin是一种选择性Cav3 (T-type) 电压门控Ca2+通道抑制剂,对Cav3.1 (α1G T-type) Ca2+通道的Kd值为15 nM。该化合物与中枢和外周神经元的L型、N型和P型Ca2+通道有高度亲和性,并对电压门控Na+通道也有交叉反应性。 | |||
T80459 |
ω-Conotoxin CnVIIA
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
ω-Conotoxin CnVIIA为含27个氨基酸的神经肽类毒素,具有N型钙电流阻滞活性。 | |||
T68806 |
Azelnidipine, (S)-
|
||
Azelnidipine, (S)-, is an L-type calcium channel blocker (CCB). Studies have shown that in patients with hypertension (HT) and heart failure preserved ejection fraction (HFpEF), azelnidipine improved the severity of HF and cardiac sympathetic nerve activity compared with cilnidipine, an N-type CCB (Cat#326734). | |||
TP2062 |
ω-Conotoxin GVIA
|
||
Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo. | |||
T37966 |
T-91825
|
||
T-91825 (PPI-0903M) is a potent N-phosphono-type cephalosporin compound, which serves as the active variant of TAK-599. It exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria [1][2]. | |||
T67833 |
HIV-1 inhibitor-54
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-1 inhibitor-54 是一种有效的 HIV-1 抑制剂,在 MT-4 细胞中对 WT HIV-1 (菌株 IIIB) x 显示出抗 HIV 活性(EC50 : 32 nM)。HIV-1 inhibitor-54 可用于研究病毒感染。 | |||
T35921 |
N-Oleoyl Valine
|
||
N-Oleoyl valine is an endogenous N-acyl amine that acts as an antagonist at the transient receptor potential vanilloid type 3 (TRPV3) receptor, which is involved in thermoregulation. N-Oleoyl valine is increased in mice following cold exposure for up to at least 16 days. Acute lung injury in mice increases the concentration of N-Oleoyl valine in lung tissue. N-acyl amines also promote mitochondrial uncoupling. | |||
T75409 | Nucleoside hydrolase (IAGNH) | ||
Nucleoside hydrolase (IAGNH)为一种糖苷酶,专门催化核苷中N-糖苷键的裂解,从而促进核碱基与Rib的循环利用。 | |||
T62876 | MONIRO-1 | ||
MONIRO-1 是一种 T 型和 N 型钙通道阻断剂,作用于 hCav2.2 (IC50: 34 μM)、hCav3.1 (IC50: 3.3 μM)、hCav3.2 (IC50: 1.7 μM) 和 hCav3.3 (IC50: 7.2 μM)。 | |||
T75793 |
ω-Agatoxin IVA TFA
|
||
ω-Agatoxin IVA TFA 是一种高效的针对P/Q型Ca2+(Cav2.1)通道的选择性阻滞剂,IC50对P型为2 nM,对Q型为90 nM。此化合物能够抑制高钾条件下的谷氨酸释放和钙流入,IC50在30-225 nM范围。同时,ω-Agatoxin IVA TFA阻断高钾诱发的5-羟色胺及去甲肾上腺素释放,但不影响L型或N型Ca2+通道。 | |||
TP1471 |
Ziconotide TFA (107452-89-1 free base)
Ziconotide TFA |
||
Ziconotide TEA acts by binding to N-type calcium channels situated on the terminal part of primary afferent neurons of the nociceptive pathway therefore reducing synaptic transmission with potent antinociceptive effects. | |||
T75726 |
ω-Conotoxin MVIIC TFA
|
||
ω-Conotoxin MVIIC TFA 是一种阻断N和P/Q型钙通道(Ca2+ channel)的化合物,能显著抑制由11-keto-βboswellic acid介导的谷氨酸释放。 | |||
T80161 |
ω-Conotoxin SO3
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
ω-Conotoxin SO3为N型电压敏感钙通道的特异性阻断剂,源自C. striatus毒液,具备镇痛功能。 | |||
T75710 |
Ziconotide TFA
|
||
Ziconotide TFA (SNX-111 TFA),一种肽类化合物,作为高效且选择性的N型钙通道拮抗剂,能减少突触传递,适用于慢性疼痛的研究。 | |||
T16135 |
MRS 1523
|
Others | Others |
MRS 1523 can exert an antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons. MRS 1523 is an effective and selective adenosine A3 receptor antagonist Ki: 18.9 nM and 113 n | |||
T80164 |
α-Conotoxin PeIA
|
||
α-Conotoxin PeIA 是一种具有镇痛作用的 α-芋螺毒素,能够抑制 α6β4、α9α10 和 α3β2 nAChR。同时,α-Conotoxin PeIA 亦作为 N 型 calcium channel 的效力抑制剂,通过激活 GABAB 受体发挥作用。 | |||
T75400 | N-Acetylhexosamine kinase (NahK) | ||
N-Acetylhexosamine kinase(NahK)是一种针对葡萄糖型底物的异头激酶,通过催化GlcNAc或GalNAc与ATP在异头C1位置发生磷酸化反应,生成N-乙酰己糖胺1-磷酸(GlcNAc-1P/GalNAc-1P)。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN7054 |
N-Formylcytisine
N-甲酰金雀花碱,(-)-N-Formylcytisine |
Others | Others |
N-Formylcytisine ((-)-N-Formylcytisine) 是一种提取自 Maackia amurensis 的茎皮中的生物碱。 | |||
T12039 |
Miglustat
N-Butyldeoxynojirimycin,OGT918,美格鲁特,NB-DNJ,N-丙基脱氧野尻霉素 |
Others | Others |
Miglustat (NB-DNJ) 是一种葡萄糖神经酰胺合成酶抑制剂,可用于I 型戈谢病。 | |||
T6S1500 |
Ginsenoside Rf
人参皂苷 Rf,Ginsenoside-Rf,Panaxoside Rf |
Calcium Channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism |
Ginsenoside Rf (Panaxoside Rf) 是人参根的微量成分,可抑制 N 型 Ca2+通道。 | |||
T8716 |
physalin F
酸浆苦味素F,酸浆苦素 F |
Apoptosis | Apoptosis |
Physalin F 是一种分泌型甾体,诱导人外周血单个核细胞凋亡,降低人 T 淋巴细胞 1 型病毒感染后的自发增殖和细胞因子的产生,具有强烈抗炎和免疫调节作用。 | |||
T6975 |
Sarcosine
Sarcosinic acid,Methylaminoacetic acid,Sarcosin,肌氨酸,Methylglycine,N-Methylaminoacetic acid,N-methylglycine |
Others; GlyT; Endogenous Metabolite | Metabolism; Neuroscience; Others |
Sarcosine (Methylglycine) 是 I 型甘氨酸转运蛋白 (GlyT1) 的竞争性抑制剂和 N-甲基-D-天冬氨酸受体 (NMDAR) 共激动剂,通过增加甘氨酸的浓度增强 NMDA 受体的功能,可用于精神分裂症的研究。 | |||
T5267 |
N-Acetyl-L-glutamic acid
Ac-L-Glu-OH,N-乙酰-L-谷氨酰胺,N-Acetylglutamic acid |
Others; Endogenous Metabolite | Metabolism; Others |
N-Acetyl-L-glutamic acid (Ac-L-Glu-OH) 是一种 N-Acyl-L-氨基酸,是动物细胞培养基的组成成分,是一种酿酒酵母和人类的代谢物。 | |||
T4716 |
Pyrrole-2-carboxylic acid
吡咯-2-羧酸,2-Pyrrolecarboxylic acid,Minaline |
Endogenous Metabolite | Metabolism |
Pyrrole-2-carboxylic acid (Minaline) 是一种天然生物碱类,从海洋细菌Pelomonas puraquaesp. Nov 中分离得到。 | |||
T4825 |
D-(+)-Xylose
D(+)-Xylose,木糖,(+)-Xylose,Wood sugar |
Endogenous Metabolite | Metabolism |
D-(+)-Xylose (Wood sugar) 是一种是一种戊醛糖,其化学式为C5H10O5,甜度为蔗糖的40%。木糖也存在于结缔组织的粘多糖中,有时也存在于尿液中。 | |||
T82572 |
D-Glucosyl-β-1,1′-N-palmitoylsphingosine
C16 Glucosyl(β) Ceramide (d18:1/16:0) |
||
D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) 是内源性Mincle配体,具免疫刺激活性。 |