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CLEC10A Protein, Human, Recombinant (His)

CLEC10A Protein, Human, Recombinant (His)

产品编号 TMPJ-00201
别名: HML, C-Type Lectin Domain Family 10 Member A, CLECSF14, CLEC10A, Macrophage Lectin 2, CD301, C-Type Lectin Superfamily Member 14, CLECSF13

C-Type Lectin Domain Family 10 Member A (CLEC10A) is a type II transmembrane C-type lectin that is expressed on immature myleloid dendritic cells and alternatively activated (tolerogenic) macrophages. CLEC10A/MGL binds and internalizes molecules with terminal nonsialylated GalNAc carbohydrates such as the Tn carcinoma antigen. CLEC10A/MGL also binds the GP envelope glycoprotein on Marburg and Ebola viruses and enhances viral entry and infectivity. It constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. CLEC10A is thought to participate in the recognition of molecules from both altered self and pathogens due to its monosaccharide specificity for Gal and N-acetylgalactosamine (GalNAc). Human and rat carry a single gene for CLEC10A/MGL, while mouse has two closely related MGL1 and MGL2 genes.

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CLEC10A Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
10 μg ¥ 620 5日内发货
50 μg ¥ 1,730 5日内发货
500 μg ¥ 12,100 5日内发货
1 mg ¥ 17,400 5日内发货
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产品目录号及名称: CLEC10A Protein, Human, Recombinant (His) (TMPJ-00201)
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产品描述 C-Type Lectin Domain Family 10 Member A (CLEC10A) is a type II transmembrane C-type lectin that is expressed on immature myleloid dendritic cells and alternatively activated (tolerogenic) macrophages. CLEC10A/MGL binds and internalizes molecules with terminal nonsialylated GalNAc carbohydrates such as the Tn carcinoma antigen. CLEC10A/MGL also binds the GP envelope glycoprotein on Marburg and Ebola viruses and enhances viral entry and infectivity. It constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. CLEC10A is thought to participate in the recognition of molecules from both altered self and pathogens due to its monosaccharide specificity for Gal and N-acetylgalactosamine (GalNAc). Human and rat carry a single gene for CLEC10A/MGL, while mouse has two closely related MGL1 and MGL2 genes.
种属 Human
表达系统 HEK293 Cells
标签 C-6xHis
蛋白编号 Q8IUN9
别名 HML, C-Type Lectin Domain Family 10 Member A, CLECSF14, CLEC10A, Macrophage Lectin 2, CD301, C-Type Lectin Superfamily Member 14, CLECSF13
氨基酸序列 Gln61-His316
蛋白构建 Gln61-His316
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 40 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 C-Type Lectin Domain Family 10 Member A (CLEC10A) is a type II transmembrane C-type lectin that is expressed on immature myleloid dendritic cells and alternatively activated (tolerogenic) macrophages. CLEC10A/MGL binds and internalizes molecules with terminal nonsialylated GalNAc carbohydrates such as the Tn carcinoma antigen. CLEC10A/MGL also binds the GP envelope glycoprotein on Marburg and Ebola viruses and enhances viral entry and infectivity. It constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. CLEC10A is thought to participate in the recognition of molecules from both altered self and pathogens due to its monosaccharide specificity for Gal and N-acetylgalactosamine (GalNAc). Human and rat carry a single gene for CLEC10A/MGL, while mouse has two closely related MGL1 and MGL2 genes.

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Keywords

CLEC10A Protein, Human, Recombinant (His) CLECSF 14 CLECSF-13 CD-301 CD 301 HML C-Type Lectin Domain Family 10 Member A CLECSF14 CLEC10A CLECSF 13 Macrophage Lectin 2 CD301 CLECSF-14 C-Type Lectin Superfamily Member 14 CLECSF13 recombinant recombinant-proteins proteins protein

 

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