IA2 Protein, Human, Recombinant (aa 687-979, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 33 KDa and the accession number is Q16849.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 μg | ¥ 1,170 | 5日内发货 | ||
50 μg | ¥ 3,470 | 5日内发货 | ||
500 μg | ¥ 12,100 | 5日内发货 | ||
1 mg | ¥ 18,900 | 5日内发货 |
产品描述 | IA2 Protein, Human, Recombinant (aa 687-979, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 33 KDa and the accession number is Q16849. |
种属 | Human |
表达系统 | E. coli |
标签 | N-6xHis |
蛋白编号 | Q16849 |
别名 | PTP IA-2, PTPRN, ICA3, R-PTP-N, ICA 512, Islet cell antigen 512, Islet cell autoantigen 3, ICA512, Receptor-type tyrosine-protein phosphatase-like N |
氨基酸序列 | Met687-Gln979 |
蛋白构建 | Met687-Gln979 |
蛋白纯度 | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 33 KDa (reducing condition) |
内毒素 | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
缓冲液 | Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0. |
存储 |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
研究背景 | Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. It implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity, may play a role in the regulation of secretory granules via its interaction with SNTB2. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. |
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IA2 Protein, Human, Recombinant (aa 687-979, His) PTP IA-2 PTPRN ICA3 ICA-512 ICA 3 R-PTP-N ICA 512 Islet cell antigen 512 ICA-3 Islet cell autoantigen 3 ICA512 Receptor-type tyrosine-protein phosphatase-like N recombinant recombinant-proteins proteins protein