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Anti-SARS-CoV-2 N Polyclonal Antibody 2

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货号 TMAB-12539

Anti-SARS-CoV-2 N Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 SARS-CoV-2 N。Anti-SARS-CoV-2 N Polyclonal Antibody 2 可用于 WB。

Anti-SARS-CoV-2 N Polyclonal Antibody 2

Anti-SARS-CoV-2 N Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
货号 TMAB-12539

Anti-SARS-CoV-2 N Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 SARS-CoV-2 N。Anti-SARS-CoV-2 N Polyclonal Antibody 2 可用于 WB。

规格价格库存数量
100 μg
¥ 2,485
5日内发货
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产品介绍

生物活性
产品描述
Anti-SARS-CoV-2 N Polyclonal Antibody 2 is a Rabbit antibody targeting SARS-CoV-2 N. Anti-SARS-CoV-2 N Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
反应种属
SARS-CoV-2
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Virion membrane ; Single-pass type I membrane protein ; Host endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein ; Host cell membrane ; Single-pass type I membrane protein ;Note: Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Colocalizes with S in the host endoplasmic reticulum-Golgi intermediate compartment. Some S oligomers are transported to the host plasma membrane, where they may mediate cell-cell fusion.
组织特异性The cytoplasmic Cys-rich domain is palmitoylated. Spike glycoprotein is digested within host endosomes.Specific enzymatic cleavages in vivo yield mature proteins. The precurssor is processed into S1 and S2 by host cell furin or another cellular protease to yield the mature S1 and S2 proteins (PubMed:32155444). Additionally, a second cleavage leads to the release of a fusion peptide after viral attachment to host cell receptor (By similarity). The presence of a furin polybasic cleavage site sets SARS-CoV-2 S apart from SARS-CoV S that possesses a monobasic S1/S2 cleavage site processed upon entry of target cells (PubMed:32155444).Highly decorated by heterogeneous N-linked glycans protruding from the trimer surface.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The SARS-CoV-2 spike (S) protein is the target of vaccine design efforts to end the COVID-19 pandemic. Despite a low mutation rate, isolates with the D614G substitution in the S protein appeared early during the pandemic, and are now the dominant form worldwide. Here, we analyze the D614G mutation in the context of a soluble S ectodomain construct.
抗原信息
免疫原
Recombinant Protein: SARS-CoV-2 Nucleocapsid protein
基因名称
S
蛋白名称
Spike glycoprotein
功能
attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.
化学信息
分子量Theoretical: 46 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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