Name: Eplontersen
Brand: TargetMol
SKU: T74645
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 2,020

2-4周

5 mg

¥ 4,100

2-4周

10 mg

¥ 6,850

2-4周

50 mg

待询

2-4周

生物活性

产品描述	Eplontersen is a triantennary N-acetylgalactosamine–conjugated antisense oligonucleotide that selectively inhibits both wild-type and mutant transthyretin mRNA, thereby reducing pathogenic TTR protein production and amyloid fibril formation associated with ATTR amyloidosis affecting cardiac and peripheral nerve tissues.
体内活性	在表达人类转甲状腺素蛋白 (hTTR) 的转基因 C57BL/6 小鼠体内研究中，Eplontersen 表现出剂量依赖性的基因沉默活性。以 0.6、2 和 6 mg/kg 的剂量（每周一次，持续 3 周）进行皮下注射 (s.c.) 后，该物质导致 TTR 表达降低。在 6 mg/kg 剂量组中，观察到肝脏 TTR mRNA 水平降至基线的 15%，而到第 17 天，血浆 TTR 蛋白水平降至 21% [3]。
别名	依普隆特生

化学信息

分子量	8606.50
CAS No.	1637600-16-8
Sequence	DNA, d([2′-O-(2-methoxyethyl)]m5rU-sp-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rG-G-sp-T-sp-T-sp-A-sp-m5C-sp-A-sp-T-sp-G-sp-A-sp-A-sp-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rC-sp-[2′-O-(2-methoxyethyl)]m5rC-sp-[2′-O-(2-methoxyethyl)]m5rC), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate]

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 80.00 mg/mL (9.30 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	0.1162 mL	0.5810 mL	1.1619 mL	5.8096 mL
5 mM	0.0232 mL	0.1162 mL	0.2324 mL	1.1619 mL

Eplontersen