BCL

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.

Cat. No.	Product Name	CAS No.	Purity
T12629L	MIK665 化合物MIK665	1799631-75-6	98%
T12629L	MIK665 (S-64315) 对髓系细胞白血病具有抑制作用。
T77332	TV 3279 化合物TV 3279	209394-29-6	98%
T77332	TV 3279是一种新型ChE-MAI 抑制剂，神经保护特性取决于它们诱导抗凋亡蛋白PKC、Bcl-2、Bcl-x 和SOD 的能力，并阻止促凋亡酶甘油醛磷酸脱氢酶在PC-12和神经母细胞瘤细胞中的核易位。
TN2180	Sappanchalcone 化合物Sappanchalcone	94344-54-4	98%
TN2180	Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.
TN3404	Altholactone 化合物 TN3404	65408-91-5	98%
TN3404	Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
TN2257	Tanshinone IIB 化合物Tanshinone IIB	17397-93-2	98%
TN2257	Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a...
TN4394	Kobophenol A 化合物 TN4394	124027-58-3	98%
TN4394	Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
T10434	AZD-5991 化合物 T10434	2143061-81-6	98%
T10434	AZD-5991 is a potent and selective Mcl-1 inhibitor (IC50: 0.7 nM in FRET assay; Kd: 0.17 nM in SPR assay).
T12824	S55746 hydrochloride 化合物 T12824	1448525-91-4	98%
T12824	S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.
TN1642	Ferruginol 化合物Ferruginol	514-62-5	98%
TN1642	Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce ap...
T13454	(S)-Purvalanol B 化合物 T13454	2310135-61-4	98%
T13454	(S)-Purvalanol B 是 Purvalanol B 的 S 对映体，Purvalanol B 是一种细胞周期蛋白依赖性激酶（CDK）抑制剂。
TN3587	Capillarisin 化合物 TN3587	56365-38-9	98%
TN3587	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN4877	Quercetin 3,4'-dimethyl ether 化合物 TN4877	33429-83-3	98%
TN4877	Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ...
T13338	WEHI-9625 化合物 T13338	2595314-46-6	98%
T13338	WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).
TN3708	Coronarin D 化合物 TN3708	119188-37-3	98%
TN3708	Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
T11968	MCL-1/BCL-2-IN-1 化合物 T11968	2493256-46-3	98%
T11968	MCL-1/BCL-2-IN-2 (Compound Nap-1) 是一种有效的选择性 Mcl-1和 Bcl-2双重抑制剂，IC50分别为 4.45 和 3.18 μM。
T14846	Bz 423 化合物 T14846	216691-95-1	98%
T14846	Bz 423 is a pro-apoptotic 1,4-benzodiazepine with selectivity for autoreactive lymphocytes and activates Bax and Bak.
T16089	MK-0674 化合物 T16089	887781-62-6	98%
T16089	MK-0674 is an effective and selective cathepsin K inhibitor (IC50: 0.4 nM). It also displays 1156, 1465, 11857, and 243 fold selectivity over Cat B, Cat F, Cat L...
T10463	Bax inhibitor peptide V5 化合物 T10463	579492-81-2	98%
T10463	Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor with anticancer activity.
TN4774	Physalin A 化合物 TN4774	23027-91-0	98%
TN4774	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
T6650	Sabutoclax 化合物Sabutoclax	1228108-65-3	98%
T6650	Sabutoclax 是一种泛 Bcl-2 抑制剂，包括 Bcl-xL、Bcl-2、Mcl-1 和 Bfl-1，IC50 分别为 0.31 μM、0.32 μM、0.20 μM 和 0.62 μM。