BCL

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.

Cat. No.	Product Name	CAS No.	Purity
T14846	Bz 423 化合物Bz 423	216691-95-1	98.89%
T14846	Bz 423 是一种有效的免疫调节剂，通过激活 Bax 和 Bak 来诱导线粒体外膜通透和细胞色素 c 释放来诱导细胞凋亡。Bz 423 在狼疮小鼠模型中显示出部分活性。
TN2180	Sappanchalcone 化合物Sappanchalcone	94344-54-4	97.00%
TN2180	Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.
TN3404	Altholactone 化合物 TN3404	65408-91-5	98%
TN3404	Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
TN2257	Tanshinone IIB 化合物Tanshinone IIB	17397-93-2	98%
TN2257	Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a...
TN4394	Kobophenol A 化合物 TN4394	124027-58-3	98%
TN4394	Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
T10434	AZD-5991 化合物 T10434	2143061-81-6	98%
T10434	AZD-5991 is a potent and selective Mcl-1 inhibitor (IC50: 0.7 nM in FRET assay; Kd: 0.17 nM in SPR assay).
T12824	S55746 hydrochloride 化合物 T12824	1448525-91-4	98%
T12824	S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.
TN1642	Ferruginol 化合物Ferruginol	514-62-5	98%
TN1642	Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce ap...
T13454	(S)-Purvalanol B 化合物 T13454	2310135-61-4	98%
T13454	(S)-Purvalanol B 是 Purvalanol B 的 S 对映体，Purvalanol B 是一种细胞周期蛋白依赖性激酶（CDK）抑制剂。
TN3587	Capillarisin 化合物 TN3587	56365-38-9	98%
TN3587	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN4877	Quercetin 3,4'-dimethyl ether 化合物 TN4877	33429-83-3	98%
TN4877	Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ...
T13338	WEHI-9625 化合物 T13338	2595314-46-6	98%
T13338	WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).
T30969	Clitocine 克力托辛	105798-74-1	98%
T30969	Clitocine 是一种来从蘑菇中提取的一种腺苷类似物，是一种有效的转录通读剂，是一种无义突变的抑制剂，具有抗癌活性，可诱导携带 p53 无义突变等位基因的细胞产生 p53 蛋白。Clitocine 通过促进 Mcl-1 降解来增强 TRAIL 介导的人结肠癌细胞凋亡。
TN3708	Coronarin D 化合物 TN3708	119188-37-3	98%
TN3708	Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
T11968	MCL-1/BCL-2-IN-1 化合物 T11968	2493256-46-3	98%
T11968	MCL-1/BCL-2-IN-2 (Compound Nap-1) 是一种有效的选择性 Mcl-1和 Bcl-2双重抑制剂，IC50分别为 4.45 和 3.18 μM。
T10463	Bax inhibitor peptide V5 化合物 T10463	579492-81-2	98%
T10463	Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor with anticancer activity.
TN4774	Physalin A 化合物 TN4774	23027-91-0	98%
TN4774	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
TN4999	Serratenediol 化合物 TN4999	2239-24-9	98%
TN4999	Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects be...
T16694	Pyridoclax 化合物 T16694	1651890-44-6	98%
T16694	Pyridoclax is an inhibitor of potential Mcl-1.
T13922	Thevetiaflavone 黄花夹竹桃黄酮	29376-68-9	98%
T13922	Thevetiaflavone (2-Genistein-5-methyl ether) 是一种来自 Wikstroemia indica 的天然类黄酮，可抑制乳酸脱氢酶从细胞质中泄漏并提高细胞活力。