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BCL

BCL

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.
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Cat. No. Product Name CAS No. Purity Chemical Structure
T12629L MIK665
化合物MIK665
1799631-75-6 98%
MIK665 (S-64315) 对髓系细胞白血病具有抑制作用。
T77332 TV 3279
化合物TV 3279
209394-29-6 98%
TV 3279是一种新型ChE-MAI 抑制剂 ,神经保护特性取决于它们诱导抗凋亡蛋白PKC、Bcl-2、Bcl-x 和SOD 的能力,并阻止促凋亡酶甘油醛磷酸脱氢酶在PC-12和神经母细胞瘤细胞中的核易位。
TN2180 Sappanchalcone
化合物Sappanchalcone
94344-54-4 98%
Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.
TN3404 Altholactone
化合物 TN3404
65408-91-5 98%
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
TN2257 Tanshinone IIB
化合物Tanshinone IIB
17397-93-2 98%
Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a...
TN4394 Kobophenol A
化合物 TN4394
124027-58-3 98%
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
T10434 AZD-5991
化合物 T10434
2143061-81-6 98%
AZD-5991 is a potent and selective Mcl-1 inhibitor (IC50: 0.7 nM in FRET assay; Kd: 0.17 nM in SPR assay).
T12824 S55746 hydrochloride
化合物 T12824
1448525-91-4 98%
S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.
TN1642 Ferruginol
化合物Ferruginol
514-62-5 98%
Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce ap...
T13454 (S)-Purvalanol B
化合物 T13454
2310135-61-4 98%
(S)-Purvalanol B 是 Purvalanol B 的 S 对映体,Purvalanol B 是一种细胞周期蛋白依赖性激酶(CDK)抑制剂。
TN3587 Capillarisin
化合物 TN3587
56365-38-9 98%
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN4877 Quercetin 3,4'-dimethyl ether
化合物 TN4877
33429-83-3 98%
Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ...
T13338 WEHI-9625
化合物 T13338
2595314-46-6 98%
WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).
TN3708 Coronarin D
化合物 TN3708
119188-37-3 98%
Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
T11968 MCL-1/BCL-2-IN-1
化合物 T11968
2493256-46-3 98%
MCL-1/BCL-2-IN-2 (Compound Nap-1) 是一种有效的选择性 Mcl-1和 Bcl-2双重抑制剂,IC50分别为 4.45 和 3.18 μM。
T14846 Bz 423
化合物 T14846
216691-95-1 98%
Bz 423 is a pro-apoptotic 1,4-benzodiazepine with selectivity for autoreactive lymphocytes and activates Bax and Bak.
T16089 MK-0674
化合物 T16089
887781-62-6 98%
MK-0674 is an effective and selective cathepsin K inhibitor (IC50: 0.4 nM). It also displays 1156, 1465, 11857, and 243 fold selectivity over Cat B, Cat F, Cat L...
T10463 Bax inhibitor peptide V5
化合物 T10463
579492-81-2 98%
Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor with anticancer activity.
TN4774 Physalin A
化合物 TN4774
23027-91-0 98%
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
T6650 Sabutoclax
化合物Sabutoclax
1228108-65-3 98%
Sabutoclax 是一种泛 Bcl-2 抑制剂,包括 Bcl-xL、Bcl-2、Mcl-1 和 Bfl-1,IC50 分别为 0.31 μM、0.32 μM、0.20 μM 和 0.62 μM。
MIK665
T12629L
MIK665 (S-64315) 对髓系细胞白血病具有抑制作用。
TV 3279
T77332
TV 3279是一种新型ChE-MAI 抑制剂 ,神经保护特性取决于它们诱导抗凋亡蛋白PKC、Bcl-2、Bcl-x 和SOD 的能力,并阻止促凋亡酶甘油醛磷酸脱氢酶在PC-12和神经母细胞瘤细胞中的核易位。
Sappanchalcone
TN2180
Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.
Altholactone
TN3404
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
Tanshinone IIB
TN2257
Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a...
Kobophenol A
TN4394
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
AZD-5991
T10434
AZD-5991 is a potent and selective Mcl-1 inhibitor (IC50: 0.7 nM in FRET assay; Kd: 0.17 nM in SPR assay).
S55746 hydrochloride
T12824
S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.
Ferruginol
TN1642
Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce ap...
(S)-Purvalanol B
T13454
(S)-Purvalanol B 是 Purvalanol B 的 S 对映体,Purvalanol B 是一种细胞周期蛋白依赖性激酶(CDK)抑制剂。
Capillarisin
TN3587
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
Quercetin 3,4'-dimethyl ether
TN4877
Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ...
WEHI-9625
T13338
WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).
Coronarin D
TN3708
Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
MCL-1/BCL-2-IN-1
T11968
MCL-1/BCL-2-IN-2 (Compound Nap-1) 是一种有效的选择性 Mcl-1和 Bcl-2双重抑制剂,IC50分别为 4.45 和 3.18 μM。
Bz 423
T14846
Bz 423 is a pro-apoptotic 1,4-benzodiazepine with selectivity for autoreactive lymphocytes and activates Bax and Bak.
MK-0674
T16089
MK-0674 is an effective and selective cathepsin K inhibitor (IC50: 0.4 nM). It also displays 1156, 1465, 11857, and 243 fold selectivity over Cat B, Cat F, Cat L...
Bax inhibitor peptide V5
T10463
Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor with anticancer activity.
Physalin A
TN4774
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
Sabutoclax
T6650
Sabutoclax 是一种泛 Bcl-2 抑制剂,包括 Bcl-xL、Bcl-2、Mcl-1 和 Bfl-1,IC50 分别为 0.31 μM、0.32 μM、0.20 μM 和 0.62 μM。
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