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  • 抑制剂&激动剂
    869
    TargetMol | Inhibitors_Agonists
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  • Adenosine N1-oxide
    腺苷氮氧化物, ANO, Adenosine, 1-oxide, Adenosine N1 oxide, 1-Oxoadenosine
    T23636146-92-9
    Adenosine N1-oxide (1-Oxoadenosine) 是在蜂王浆中发现的腺苷 N1-氧化物,可抑制活化的巨噬细胞分泌炎症介质,并降低脂多糖 (LPS) 诱导的内毒素休克的致死率。
    • ¥ 513
    In stock
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  • Adenosine receptor antagonist 4
    T21620133240-06-9In house
    Adenosine receptor antagonist 4 是一种腺苷受体拮抗剂。
    • ¥ 99
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    TargetMol | Inhibitor Sale
  • Adenosine receptor A1 antagonist 5
    T2246685872-53-3In house
    Adenosine receptor A1 antagonist 5 可作为一种腺苷拮抗剂,是一种氧嘌呤,可作为杀虫剂和虫害防治剂,对血压升高有抑制作用。
    • ¥ 288
    In stock
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    TargetMol | Inhibitor Sale
  • Adenosine A1 receptor activator T62
    T1412740312-34-3
    Adenosine A1 receptor activator T62 是腺苷 A1 受体的变构增强剂,有镇痛作用。
    • ¥ 498
    In stock
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    TargetMol | Inhibitor Sale
  • Adenosine-2'-monophosphate
    2'-AMP, AMP 2'-phosphate, Adenosine 2'-phosphate, 2'-Adenylic acid
    T20054130-49-4
    Adenosine-2'-monophosphate (2'-AMP) 是由 2’,3'-CAMP 转化的核苷,抑制小胶质细胞产生炎性细胞因子,通过 A2A 受体抑制活化的原代小鼠小胶质细胞产生 TNF-α 和 CXCL10。
    • ¥ 279
    In stock
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  • Adenosine Kinase siRNA-2
    T203514
    Adenosine Kinase siRNA-2 是小干扰 RNA,专门作用于adenosine kinase的信使 RNA。
    • 待询
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  • Adenosine 5′-diphosphoribose
    T20535020762-30-5
    Adenosine 5′-diphosphoribose (ADP ribose) 由腺嘌呤和核糖通过两个磷酸基团连接而成。Adenosine 5′-diphosphoribose 是在多种细胞过程中扮演关键角色的分子,尤其是涉及 DNA 损伤反应和基因表达调控的过程中。
    • 待询
    10-14周
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  • Adenosine Kinase Inhibitor (hydrate)
    T22554
    Adenosine kinase is the key metabolizing enzyme regulating cellular adenosine concentrations. Inhibition of adenosine kinase can selectively enhance the protective actions of adenosine during tissue trauma without producing the nonspecific effects associa
    • ¥ 776
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  • 2-Ethynyl Adenosine
    2-Ethynyl-Adenosine, 2-Ethynyl-Ade, 2 Ethynyl Adenosine
    T2934799044-57-2
    2-Ethynyl Adenosine is an Adenosine derivative that is used to capture novel polyadenylated transcription and non-radiochemical reporter molecules of the protein AMPylation.
    • 待询
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  • LNA-Adenosine
    LNA-A, LNA Adenosine, 2'-O,4'-C-Methyleneadenosine
    T32826206055-70-1
    LNA-Adenosine (LNA-A) 是一种核苷类似物,可作为作为腺苷A3受体配体。
    • ¥ 199
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  • Adenosine 3'-monophosphate (sodium salt hydrate)
    T35571
    Adenosine 3’-monophosphate is a nucleotide and metabolite formedviahydrolysis of 2’,3’-cAMP by metal-dependent phosphodiesterases.1It reduces proliferation of rat preglomerular vascular smooth muscles cells (PGVSMCs) and glomerular mesangial cells (GMCs) in a concentration-dependent manner, an effect that is abolished by the adenosine A2Breceptor antagonist MRS1754.2Adenosine 3’-monophosphate is also a metabolic intermediate in the biosynthesis of adenosine .
    • ¥ 443
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  • Adenosine 5'-methylenediphosphate (hydrate)
    T35573
    Adenosine 5’-methylenediphosphate is an inhibitor of ecto-5’-nucleotidase, also known as CD73, with a Kivalue of 37 nM.1It inhibits cAMP accumulation induced by adenosine 5’-monophosphate , adenosine 5’-diphosphate , or adenosine 5’-triphosphate but not adenosine in VA-13 human fibroblasts when used at a concentration of 100 μM. Adenosine 5’-methylenediphosphate reduces proliferation of U138MG glioma cells, as well as inhibits the invasion and migration of MHCC97H hepatocellular carcinoma (HCC) cells in a migration assay.2,3It increases tumor infiltration of CD3+CD8+T cells and reduces tumor growth in a K1735 murine melanoma model when administered at a dose of 400 μg mouse.4 1.Bruns, R.F.Adenosine receptor activation by adenine nucleotides requires conversion of the nucleotides to adenosineNaunyn Schmiedebergs Arch. Pharmacol.315(1)5-13(1980) 2.Braganhol, E., Tamajusuku, A.S.K., Bernardi, A., et al.Ecto-5′-nucleotidase CD73 inhibition by quercetin in the human U138MG glioma cell lineBiochim. Biophys. Acta1770(9)1352-1359(2007) 3.Shali, S., Yu, J., Zhang, X., et al.Ecto 5′ nucleotidase (CD73) is a potential target of hepatocellular carcinomaJ. Cell Physiol.234(7)10248-10259(2018) 4.Forte, G., Sorrentino, R., Montinaro, A., et al.Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanomaJ. Immunol.189(5)2226-2233(2021)
    • ¥ 1290
    35日内发货
    规格
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  • Adenosine 5′-monophosphoramidate sodium
    T38415102029-68-5
    Adenosine 5′-monophosphoramidate sodium is a derivative of adenosine used as an intermediate for nucleotide synthesis. It significantly influences the accumulation of cyclic AMP.
    • ¥ 2480
    5日内发货
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  • Guanosine 5'-triphosphate-5'-adenosine
    Guanosine 5'-triphosphate-5'-adenosine, GpppA
    T3844910527-47-6
    Guanosine 5'-triphosphate-5'-adenosine, the 5′ cap analog, is a fluorescent substrate analog.
    • 待询
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  • N6-Benzyl-5'-ethylcarboxamido adenosine
    N6-Benzyl-5'-ethylcarboxamido adenosine
    T39011152918-32-6
    N6-Benzyl-5'-ethylcarboxamido adenosine is a selective A3 adenosine receptor agonist.
    • 待询
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  • Adenosine 2',5'-diphosphate sodium
    T39025154146-84-6
    Adenosine 2',5'-diphosphate sodium is a competitive P2Y1 antagonist with non-selective antagonism at recombinant and human platelet P2X1 receptors.
    • 待询
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  • Adenosine receptor antagonist 1
    T403072682930-40-9
    Adenosine receptor antagonist 1 is a highly selective antagonist for the A2aR adenosine receptor, exhibiting an IC50 value of 0.29 nM. It demonstrates a remarkable 14-fold selectivity towards the A2aR receptor in comparison to the A2bR receptor.
    • ¥ 10600
    6-8周
    规格
    数量
  • N7-Methyl-guanosine-5'-triphosphate-5'-adenosine
    N7-Methyl-guanosine-5'-triphosphate-5'-adenosine, m7GpppA
    T4072162828-63-1
    N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) is a dinucleotide cap analog employed in the process of in vitro RNA transcription.
    • 待询
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  • Adenosine receptor antagonist 3
    T608722400864-80-2
    Adenosine receptor antagonist 3 具有用于癌症疾病研究的潜力,它是腺苷受体的有效拮抗剂。
    • ¥ 1290
    5日内发货
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  • adenosine receptor inhibitor 1
    T618502550400-52-5
    Adenosine receptor inhibitor 1 is a highly potent and selective antagonist of adenosine receptor (AR). It exhibits exceptional affinity for A1 AR, A2A AR, A2B AR, and A3 AR, with respective Ki values of >1000, 68.5, >1000, >1000 nM. This compound demonstrates notable antinociceptive, anti-inflammatory, and peripheral analgesic properties. Therefore, Adenosine receptor inhibitor 1 holds great promise for investigating cancer and neurodegenerative diseases [1].
    • ¥ 10600
    6-8周
    规格
    数量
  • adenosine receptor inhibitor 2
    T620182550401-76-6
    Adenosine receptor inhibitor 2 (compound 14b) 是有效的AR(腺苷受体)抑制剂。Adenosine receptor inhibitor 2 显示对 A1 A2AARs 的双重亲和性,对 A1- 的亲和性比A2AAR 更高。Adenosine receptor inhibitor 2 抑制A1AR 和A2AAR 的Ki 分别为 52.2 和 167 nM。
    • ¥ 10600
    6-8周
    规格
    数量
  • adenosine receptor antagonist 2
    T626112703054-47-9
    Adenosine receptor antagonist 2 是一种具有口服活性的 A2a (IC50: 1 nM) A2b (IC50: 3 nM) 腺苷受体拮抗剂。Adenosine receptor antagonist 2 表现出抗肿瘤效果。
    • ¥ 18549
    6-8周
    规格
    数量
  • L-Adenosine
    T650083080-29-3
    L-Adenosine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65008,CAS号为 3080-29-3。
    • ¥ 561
    5日内发货
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  • Adenosine-5'-diphosphate disodium salt
    T7192716178-48-6
    Adenosine 5'-diphosphate disodium salt has been shown to inhibit the binding of serotonin (5-hydroxytryptamine) to 5-HT2 receptors, which are present in heart tissue.
    • ¥ 141
    6-8周
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