规格

价格

库存

数量

1 mg

¥ 903

现货

5 mg

¥ 2,300

现货

10 mg

¥ 3,310

现货

25 mg

¥ 5,080

现货

50 mg

¥ 6,850

现货

100 mg

¥ 9,230

现货

200 mg

¥ 12,300

现货

1 mL x 10 mM (in DMSO)

¥ 2,550

现货

生物活性

产品描述	Trabodenoson (INO-8875) is a selective and potent adenosine A1 receptor agonist, an adenosine analog, for the study of primary open-angle glaucoma.
体外活性	Treatment with Trabodenoson significantly increases MMP-2 activity and MMP-14 abundance, while decreasing expression of fibronectin and collagen IV[2].
体内活性	Trabodenoson (6.0%) demonstrates an average IOP drop of 2.45 ± 0.38 mm Hg in young mice over 7 days (downregulation)[2]. In induced eyes, topical trabodenoson significantly upregulates nestin expression in the ONH compared with vehicle-treated non-induced eyes[1]. Trabodenoson-treated eyes show significantly reduced optic nerve (ON) edema compared with vehicle-treated eyes. Additionally, RGC counts are higher in Trabodenoson-treated eyes compared to vehicle, accounting for 74% versus 47% of the contralateral eye[1].
别名	曲波迪松, PJ-875, PJ875, PJ 875, INO-8875, INNO-8875, INNO8875, INNO 8875

化学信息

分子量	380.36
分子式	C₁₅H₂₀N₆O₆
CAS No.	871108-05-3
Smiles	O[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@H]([C@@H]1O)n1cnc2c(NC3CCCC3)ncnc12
密度	1.87 g/cm3 (Predicted)

储存&溶解度

存储

溶解度信息

DMSO: 100 mg/mL (262.91 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.52 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6291 mL	13.1454 mL	26.2909 mL	131.4544 mL
5 mM	0.5258 mL	2.6291 mL	5.2582 mL	26.2909 mL
10 mM	0.2629 mL	1.3145 mL	2.6291 mL	13.1454 mL
20 mM	0.1315 mL	0.6573 mL	1.3145 mL	6.5727 mL
50 mM	0.0526 mL	0.2629 mL	0.5258 mL	2.6291 mL
100 mM	0.0263 mL	0.1315 mL	0.2629 mL	1.3145 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Trabodenoson

Trabodenoson

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

Trabodenoson

Trabodenoson

Trabodenoson 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词