LAS38096

Name: LAS38096
Brand: TargetMol
SKU: T27800
Price: 987 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.95%

货号 T27800Cas号 851371-22-7

别名 LAS-38096, LAS 38096

LAS38096 是一种A2B 腺苷受体拮抗剂（Ki ：17 nM），具有强效性、选择性和高效性。

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LAS38096

一键复制产品信息

很棒

纯度: 99.95%

货号 T27800 别名 LAS-38096, LAS 38096Cas号 851371-22-7

LAS38096 是一种A2B 腺苷受体拮抗剂（Ki ：17 nM），具有强效性、选择性和高效性。

规格	价格	库存
1 mg	¥ 987	现货
5 mg	¥ 2,350	现货
10 mg	¥ 3,260	现货
25 mg	¥ 4,700	现货
50 mg	¥ 6,380	现货
100 mg	¥ 8,590	现货
200 mg	¥ 11,600	现货

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COA HNMR LCMS 产品操作手册

产品介绍

LAS38096 AI Summary

LAS38096 exhibits significant bioactivity and modulation properties related to adenosine receptors. It shows high affinity for the human A2B receptor with a Ki value of 17.0 nM and moderate affinity for mouse A2B receptors with IC50 values of 321.0 nM in HEK293 cells and 349.0 nM in CHO cells. Additionally, it inhibits the production of NECA-induced cAMP and displays inhibitory activity on IL6 production in human (IC50 = 340.0 nM) and mouse fibroblasts (IC50 = 640.0 nM). LAS38096 also targets other adenosine receptors, presenting moderate affinity for the A3 receptor (Ki = 1043.0 nM) and low affinity for the A1 receptor (Ki = 2821.0 nM), and inhibits binding to the A2A receptor by 40% at 1 µM concentration. It has shown inhibitory potentials across various kinases, with Ki values ranging from 1258.93 nM to 6309.57 nM. Additionally, it has a high level of plasma protein binding across species (mouse, human, and rat) with values ranging from 84.0% to 86.05%, indicating strong plasma protein affinity that could influence its pharmacokinetics..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	LAS38096 is an A2B adenosine receptor antagonist (Ki : 17 nM) that is potent, selective and efficient .
靶点活性	A2A:>2500 nM (Ki), A2B:17 nM (Ki), A1:>1000 nM (Ki), A3:>1000 nM (Ki)
别名	LAS-38096, LAS 38096

化学信息

分子量	316.32
分子式	C₁₇H₁₂N₆O
CAS No.	851371-22-7
Smiles	N(c1cccnc1)c1ncc(-c2ccncn2)c(n1)-c1ccco1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (173.87 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1614 mL	15.8068 mL	31.6136 mL	158.0678 mL
5 mM	0.6323 mL	3.1614 mL	6.3227 mL	31.6136 mL
10 mM	0.3161 mL	1.5807 mL	3.1614 mL	15.8068 mL
20 mM	0.1581 mL	0.7903 mL	1.5807 mL	7.9034 mL
50 mM	0.0632 mL	0.3161 mL	0.6323 mL	3.1614 mL
100 mM	0.0316 mL	0.1581 mL	0.3161 mL	1.5807 mL