Phosphatase

A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolases. Phosphatase enzymes are essential to many biological functions, because phosphorylation (e.g. by protein kinases) and dephosphorylation (by phosphatases) serve diverse roles in cellular regulation and signaling. Whereas phosphatases remove phosphate groups from molecules, kinases catalyze the transfer of phosphate groups to molecules from ATP. Together, kinases and phosphatases direct a form of post-translational modification that is essential to the cell's regulatory network. Phosphatase enzymes are not to be confused with phosphorylase enzymes, which catalyze the transfer of a phosphate group from hydrogen phosphate to an acceptor. Due to their prevalence in cellular regulation, phosphatases are an area of interest for pharmaceutical research

Cat. No.	Product Name	CAS No.	Purity
T35528	TD52 化合物TD52	1798328-24-1	98%
T35528	TD52 是 PP2A (CIP2A) 癌性抑制剂的口服活性抑制剂。 TD52 是厄洛替尼衍生物，通过干扰 Elk1 与 CIP2A 启动子的结合间接降低了 CIP2A。
T24073	PTP1B-IN-4 化合物PTP1B-IN-4	765317-72-4	98%
T24073	PTP1B-IN-4是一种 PTP1B 的变构抑制剂，IC50为8μM。PTP1B-IN-4可用于肥胖症和糖尿病的研究。
T3827	Rhein-8-glucoside calcium 大黄酸-8-O-β-D-葡萄糖苷	113443-70-2	98%
T3827	Rhein-8-glucoside calcium salt 是一种从 Saussurea lappa 根的 EtOH 提取物中，分离得到的蒽醌类 hPTP1B 抑制剂，IC50值为11.5 μM，具有抗菌作用。
TN2887	3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid 化合物 TN2887	329975-47-5	98%
TN2887	(24E)-3,4-Seco-cucurbita-4,24-diene-3,26,29-trioic acid can inhibit the activity of protein tyrosine phosphatase 1B (PTP1B), with IC 50 values of 0.4uM.
T3930	Taraxerol acetate 醋酸蒲公英霜	2189-80-2	98%
T3930	Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS c...
TN3525	Boehmenan 化合物 TN3525	57296-22-7	98%
TN3525	(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
T11687	Itacitinib adipate 化合物 T11687	1334302-63-4	98%
T11687	Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor,Itacitinib adipate has been tested for efficacy and safety in a phase II trial in myelo...
TN3335	Abyssinone V 化合物Abyssinone V	77263-11-7	98%
TN3335	Abyssinone V 是一种从刺桐茎皮中分离的天然化合物，是蛋白质酪氨酸磷酸酶 1B (PTP1B) 的抑制剂。
T14037	3α-Aminocholestane 3α-氨基胆甾烷	2206-20-4	98%
T14037	3α-Aminocholestane , a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) , inhibitor with an IC50 of ~2.5 μM.
T11735	K-Ras G12C-IN-1 化合物 T11735	1629265-17-3	98%
T11735	K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.
T12934	SMAP-2 化合物 T12934	1809068-70-9	98%
T12934	SMAP-2 is an orally bioavailable activator of phosphatase 2A (PP2A) which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. It inhib...
TN4551	Methyl orsellinate 化合物 TN4551	3187-58-4	98%
TN4551	Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus...
T15243	Ertiprotafib 化合物 T15243	251303-04-5	98%
T15243	Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPA...
TN4064	Flavoglaucin 化合物 TN4064	523-73-9	98%
TN4064	Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
T15166	DPM-1001 化合物 T15166	1471172-27-6	98%
T15166	DPM-1001 is an orally bioavailable and non-competitive protein-tyrosine phosphatase (PTP1B) inhibitor (IC50: 100 nM) with the anti-diabetic property.
T16517	PGMI-004A 化合物PGMI-004A	1313738-90-7	98%
T16517	PGMI-004A 是磷酸甘油酸变位酶 1 抑制剂，IC50=13.1 μM。
TN3505	Beta-Peltoboykinolic acid 化合物 TN3505	24778-48-1	98%
TN3505	Beta-Peltoboykinolic acid has in vitro protein tyrosine phosphatase 1B (PTP1B) inhibitory, it inhibits PTP1B with IC50 values of 5.2+/-0.5 microM. It also has cy...
T10060L	DT-061 化合物 T10060L	1809427-19-7	98%
T10060L	DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
T12577	PTP1B-IN-3 化合物 T12577	809272-64-8	98%
T12577	PTP1B-IN-3 is a potent and selective inhibitor of PTP1B (PTP1B and TCPTP with IC50s of 120 nM and 120 nM , respectively).
TN2913	3-Acetoxy-11-ursen-28,13-olide 化合物 TN2913	35959-08-1	98%
TN2913	3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibit...