Name: SHP2-D26
Brand: TargetMol
SKU: T40121
Price: 1650 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 1,650

现货

生物活性

产品描述	SHP2-D26 is a highly potent and effective SHP2 degrader that induces targeted SHP2 protein degradation through simultaneous binding to VHL-1 and SHP2, with degradation strictly dependent on neddylation and proteasome activity, thereby providing a powerful chemical biology tool for dissecting SHP2-driven signaling networks in cancer and immune regulation.
靶点活性	SHP2:2.6 nM (DC50), SHP2:6.0 nM (DC50)
体外活性	SHP2-D26 (0, 3, 10, 30, 100, 300 nM; 12 hours) effectively reduces SHP2 protein in a dosedependent manner, with DC 50 values of 6.0 nM, 2.6 nM in KYSE520 and MV-4-11 cells, respectively[1]. SHP2-D26 (100 nM; 0, 2, 4, 8, 12, 24 hours) reduces the SHP2 protein level within 4 h and completes SHP2 depletion with 8 h in KYSE520 and MV-4-11 cells[1]. SHP2-D26 (0-100 μM for KYSE520 cells; 0-10 nM for MV-4-11 cells; 4 days) achieves IC 50 values of 0.66 μM, 0.99 nM in KYSE520 and MV-4-11 cells, respectively[1]. Cell Proliferation Assay[1]Cell Line: KYSE520 and MV-4-11 cells Concentration: 0-100 μM for KYSE520 cells; 0-10 nM for MV-4-11 cells Incubation Time: 4 days Result: Achieved IC 50 values of 0.66 μM, 0.99 nM in KYSE520 and MV-4-11 cells, respectively. Western Blot Analysis[1]Cell Line: KYSE520 and MV-4-11 cells Concentration: 0, 3, 10, 30, 100, 300 nM Incubation Time: 12 hours Result: Reduced SHP2 protein in a dosedependent manner, with DC 50 values of 6.0 and 2.6 nM in KYSE520 and MV-4-11 cells, respectively. Western Blot Analysis[1]Cell Line: KYSE520 and MV-4-11 cells Concentration: 100 nM Incubation Time: 0, 2, 4, 8, 12, 24 hours Result: Reduced the SHP2 protein level within 4 h and completed SHP2 depletion with 8 h.

化学信息

分子量	1115.9
分子式	C₅₆H₇₉ClN₁₂O₆S₂
CAS No.	2458219-65-1
Smiles	C([C@@H](NC(CCCCCCCCN1CCN(C(CCC(NC2=C(Cl)C(SC=3C(N)=NC(=CN3)N4CCC(C)(N)CC4)=CC=C2)=O)=O)CC1)=O)[C@](C)(C)C)(=O)N5[C@H](C(N[C@@H](C)C6=CC=C(C=C6)C=7SC=NC7C)=O)C[C@@H](O)C5
颜色	White
物理性状	Solid

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 65 mg/mL (58.25 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8961 mL	4.4807 mL	8.9614 mL	44.8069 mL
5 mM	0.1792 mL	0.8961 mL	1.7923 mL	8.9614 mL
10 mM	0.0896 mL	0.4481 mL	0.8961 mL	4.4807 mL
20 mM	0.0448 mL	0.2240 mL	0.4481 mL	2.2403 mL
50 mM	0.0179 mL	0.0896 mL	0.1792 mL	0.8961 mL