Name: AMG-529
Brand: TargetMol
SKU: T9901A-968
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 12,000

待询

5 mg

待询

生物活性

产品描述	AMG-529 is a humanized monoclonal antibody targeting the asialoglycoprotein receptor 1 (ASGR1). Primarily expressed on hepatocytes, ASGR1 mediates the endocytosis and degradation of circulating asialoglycoproteins. AMG-529 functions by specifically binding to ASGR1 and blocking ligand interactions, thereby inhibiting receptor function. Clinical studies demonstrate that ASGR1 inhibition leads to a dose-dependent elevation in serum alkaline phosphatase (ALP) levels, which serves as a circulating biomarker for suppressed ASGR1 activity. This antibody is utilized in research concerning lipid metabolism regulation and cardiovascular protection mechanisms.
体外活性	在生化实验中，AMG-529 表现出对人 ASGR1 胞外域的高亲和力。在细胞模型中，该抗体有效阻断了脱唾液酸糖蛋白配体的结合及其后续的内化，从而阻止了受体介导的内吞作用 [1]。
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P07306
靶点	ASGR1

储存&溶解度

存储	store at low temperature \| -20°C for 2 years, 4°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

AMG-529