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Search Results for " topoisomerase "

311

抑制剂 & 化合物

55

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T67899	Topoisomerase II inhibitor 13	Topoisomerase	DNA Damage/DNA Repair
	Topoisomerase II inhibitor 13抑制拓扑异构酶II (Topo II)，对HL-60衍生的HL-60/MX2癌细胞具有较强的抗Topo II 毒性的抗增殖活性。
T77650	Topoisomerase II inhibitor 14	Apoptosis; Antioxidant; Topoisomerase; NO Synthase	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; oxidation-reduction
	Topoisomerase II inhibitor 14 是一种有效的拓扑异构酶 II 抑制剂，具有抗癌活性和抗氧化活性。Topoisomerase II inhibitor 14 诱导细胞凋亡，并将细胞周期阻滞在 S 期。Topoisomerase II inhibitor 14 可降低 GSH、MDA 和 NO 的量。
T78717	Topoisomerase inhibitor 2	Topoisomerase	DNA Damage/DNA Repair
	Topoisomerase inhibitor2(18C)为针对细菌拓扑异构酶的抑制剂，展现出对多重耐药革兰氏阴性菌的强效广谱活性。
T64164	Topoisomerase II inhibitor 11
	Topoisomerase II inhibitor 11 (compound 3d) 是一种拓扑异构酶 II (Topoisomerase II) 的有效抑制剂 (IC50: 2.89 μM)。Topoisomerase II inhibitor 11 对肾癌 A498 细胞有 92.46% 的抑制效果 (IC50: 3.5 μM)。Topoisomerase II inhibitor 11 能够将细胞周期阻滞在 G2/M 期，抑制细胞增殖并具有凋亡活性。
T80968	Topoisomerase I inhibitor 10	Topoisomerase	DNA Damage/DNA Repair
	TopoisomeraseI inhibitor 10 (compound 13)为一种抗利什曼原虫活性药物，特别针对L. donovani promastigotes的leishmanial topoisomerase IB表现出抑制作用，IC50值为27.91 μM。
T79506	Topoisomerase II inhibitor 15	Topoisomerase	DNA Damage/DNA Repair
	TopoisomeraseII inhibitor 15 (compound 2g) 为 TopoisomeraseII 的一种抑制剂，能有效诱导细胞凋亡 (apoptotic) 并对头颈部肿瘤展示出较高选择性。
T60766	Topoisomerase I inhibitor 3
	Topoisomerase I inhibitor 3 (Compound ZML-14) 诱导 HepG2 细胞凋亡，并在 G2/M 期阻滞细胞周期。Topoisomerase I inhibitor 3 是与拓扑异构酶 I-DNA 复合物相互作用的拓扑异构酶 I 抑制剂。
T60781	Topoisomerase II inhibitor 8
	Topoisomerase II inhibitor 8 (化合物 22) 显示出良好的抗增殖活性，并将细胞周期阻滞在 G2/M 期。Topoisomerase II inhibitor 8是拓扑异构酶 II 的有效抑制剂 (IC 50 = 0.52 μM)。
T62224	Topoisomerase IIα-IN-2
	Topoisomerase IIα-IN-2 (compound 5) 是一种 DNA 结合配体 (DNA-binding ligands)，也是一种拓扑异构酶 TopoIIα的有效抑制剂。Topoisomerase IIα-IN-2 对人癌症细胞株表现出较高的抗增殖活作用。Topoisomerase IIα-IN-2 能够将癌细胞的细胞周期停滞在 G2/M 期，明显诱导 DNA 损伤。
T61717	Topoisomerase I inhibitor 4
	Topoisomerase I inhibitor 4 (compound 7a) is a potent inhibitor of topoisomerase I activity. It effectively inhibits the proliferation of various cancer cell lines including HepG2, A549, MCF-7, and HeLa, with IC50 values of 1.20 μM, 2.09 μM, 1.56 μM, and 1.92 μM, respectively. Thus, Topoisomerase I inhibitor 4 holds promise for cancer research applications [1].
T63304	Topoisomerase II inhibitor 9
	Topoisomerase II inhibitor 9 是 Topo II 抑制剂 (IC50: 0.97 μM)，也是 DNA 嵌入剂 (IC50: 43.51 μM)，能够在 G2/M 期阻滞 Hep G‐2 细胞周期，诱导细胞凋亡 (apoptosis)。
T31011	Coralyne chloride	Topoisomerase	DNA Damage/DNA Repair
	Coralyne chloride 是一种具有强抗癌活性的原小檗碱。它可用于制备 Coralyne 衍生物，是一种基于荧光 DNA 的分子整流剂，通过位点特异性插入构建成 DNA 双链体。它可作为一种拓扑异构酶 I 毒性分子，诱导拓扑异构酶 I 介导 DNA 裂解。
T36968	ARN-21934	Topoisomerase	DNA Damage/DNA Repair
	ARN-21934 是高选择性的人拓扑异构酶 II α 抑制剂，具有血脑屏障通透性。依托泊苷抑制 DNA 松弛的IC50为120 μM，ARN-21934 抑制 DNA 松弛的IC50为 2 μM。ARN-21934具有良好的体内药代动力学特性。
T26046	Razoxane	Topoisomerase	DNA Damage/DNA Repair
	Razoxane 是拓扑异构酶 II 的有效抑制剂，具有抗血管生成的作用，在肾细胞癌中具有研究价值。
T62223	Topoisomerase IIα-IN-1
	Topoisomerase IIα-IN-1 (compound 2) 是一种 DNA 结合配体 (DNA-binding ligands)，也是一种拓扑异构酶TopoIIα的有效抑制剂。Topoisomerase IIα-IN-1 对人类癌症细胞株表现出较好的抗增殖作用。
T62094	Topoisomerase I inhibitor 6
	Topoisomerase I inhibitor 6 (Compound 3) 是一种 Topoisomerase I 的有效抑制剂，可以捕获 DNA-Top1 裂解复合物，在非癌细胞系中具有较小的细胞毒性。Topoisomerase I inhibitor 6 对癌症疾病表现出潜在的研究价值。
T72154	Topoisomerase IV inhibitor 2	Topoisomerase	DNA Damage/DNA Repair
	TopoisomeraseIV inhibitor 2 (compound 5d) 是一种 DNA 拓扑异构酶 IV 抑制剂，其对 TOPO IV 和 DNA 促旋酶的 IC50 值分别为 0.35 μM 和 0.55 μM。此化合物显示出针对 Staphylococcus aureus Newman 菌株和 Escherichia coli ATCC8739 的抗菌活性，对应的 MIC 值分别为 1.985 μM 和 0.744 μM。
T61017	Topoisomerase II inhibitor 6
	Topoisomerase II inhibitor 6 (Compound 5) 是色胺酮的衍生物。它是一种有效的拓扑异构酶的选择性抑制剂。Topoisomerase II inhibitor 6 在 G2 期阻断 CCRF-CEM 的细胞周期并诱导 DNA 双链断裂。Topoisomerase II inhibitor 6 对不同的肿瘤细胞系具有抗增殖活性，在癌症疾病研究中具有潜力。
T64047	Topoisomerase II inhibitor 10
	Topoisomerase II inhibitor 10 是拓扑异构酶II (topoisomerase II) 的有效抑制剂 (IC50: 7.45 μM)。Topoisomerase II inhibitor 10 对 HepG-2、MCF-7 和 HCT-116 细胞表现出良好的抗增殖作用。Topoisomerase II inhibitor 10 能够将 HepG-2 细胞的细胞周期阻滞在 G2-M 期，并诱导其凋亡 (apoptosis)。
T60617	Topoisomerase I inhibitor 2
	Topoisomerase I inhibitor 2 是一种高度选择性的DNA 拓扑异构酶 I(Top1) 抑制剂，可抑制Top1活性并导致 DNA 损伤。Topoisomerase I inhibitor 2 阻断 G2/M 期并诱导细胞凋亡，具有抗肿瘤作用。
T61431	Topoisomerase IIα-IN-4
	Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive inhibitor of human DNA topoisomerase II, specifically inhibiting TopoIIα with an IC50 value of 3.8 μM and TopoIIβ with an IC50 value of 10.1 μM. It demonstrates significant efficacy in inducing apoptosis and arresting the cell cycle in HepG2 cells. Moreover, Topoisomerase IIα-IN-4 exhibits robust antitumor effects against various human cancer cell lines, making it a valuable compound for cancer research [1].
T72157	Topoisomerase II inhibitor 7
	TopoisomeraseII inhibitor 7 (化合物 3a) 作为一种高效的拓扑异构酶IIα亚型抑制剂，展现出3.19 μM的IC50值。其能够诱导细胞周期阻滞与凋亡。
T72153	Topoisomerase IV inhibitor 1	Topoisomerase	DNA Damage/DNA Repair
	TopoisomeraseIV inhibitor 2 (compound 7d) 作为DNA拓扑异构酶IV（TOPO IV）抑制剂，展现出高效的活性，其对TOPO IV的IC50值为0.23 μM，而对DNA促旋酶的IC50为0.43 μM。此外，该化合物在抗菌领域同样表现出较强的能力，对金黄色葡萄球菌Nerman菌株（Staphylococcus aureus Newman）和大肠杆菌ATCC8739的最小抑菌浓度（MIC）分别为0.972 μM和0.608 μM。
T61054	Type II topoisomerase inhibitor 1
	Type II topoisomerase inhibitor 1 可用于抗菌领域。Type II topoisomerase inhibitor 1 是大肠杆菌DNA 旋转酶的选择性抑制剂，IC50值为 1.7 nM，并能与 Asp73 残基形成氢键。Type II topoisomerase inhibitor 1 抑制拓扑异构酶 IV 的活性，IC50值为 0.98 μM。
T61045	Topoisomerase I/II inhibitor 2
	Topoisomerase I/II inhibitor 2 (compound 1a) 可显著抑制小鼠模型中的异种移植肿瘤的生长，可用于肝癌治疗。Topoisomerase I/II inhibitor 2 是一种DNA 拓扑异构酶 I/II 的双重抑制剂。Topoisomerase I/II inhibitor 2 是有效的拓扑异构酶抑制剂，对LM9 细胞和Huh7 细胞的 IC50值分别为 6.83 μM 和9.82 μM 。
T62002	Topoisomerase I inhibitor 7
	Topoisomerase I inhibitor 7 (Compound 8) 是有效的Topoisomerase I 抑制剂。Topoisomerase I inhibitor 7 显著抑制肿瘤生长（高达 79%）。在接受 P388 淋巴瘤移植的小鼠模型中，Topoisomerase I inhibitor 7延长了小鼠寿命（153%）。
T61501	Topoisomerase I inhibitor 5
	Topoisomerase I inhibitor 5 is an efficient inhibitor of topoisomerase I, with an IC50 value. It effectively disrupts DNA and inhibits the activity of topoisomerase I. Moreover, it can induce apoptosis in MCF-7 cells and arrest the cell cycle at the G1 phase. Topoisomerase I inhibitor 5 also exhibits potency in reversing P-gp-mediated resistance to Adriamycin [1].
T63594	Topoisomerase IIα-IN-3
	Topoisomerase IIα-IN-3 是 DNA 插入型 topoisomerase-Iiα 抑制剂，能够将细胞周期阻滞在 G0/G1 期，并诱导细胞凋亡 (apoptosis)。
T62225	Topoisomerase I inhibitor 8
	Topoisomerase I inhibitor 8 是一种喜树碱六环类似物，也是 topoisomerase I 的强效抑制剂，对肿瘤细胞有毒性。
T62887	Topoisomerase II inhibitor 4
	Topoisomerase II inhibitor 4 (compound E17) 是一种拓扑异构酶 II (Topoisomerase II) 的有效抑制剂。Topoisomerase II inhibitor 4 具有抗肿瘤效果，能够将阻滞细胞周期于 G2/M 期，抑制癌细胞增殖并表现出细胞毒性。
T80967	Topoisomerase I inhibitor 9	Topoisomerase	DNA Damage/DNA Repair
	TopoisomeraseI inhibitor 9 (compound 3d) 是针对leishmanial topoisomerase IB的抑制剂，具有针对L. donovani promastigotes的抗利什曼原虫活性，其IC50值为34.81 μM。
T63068	Topoisomerase II inhibitor 5
	Topoisomerase II inhibitor 5 (Compound E24) 是一种 DNAtopoisomerase II 抑制剂，具有抗癌作用。
T61283	Topoisomerase II inhibitor 3
	Topoisomerase II inhibitor 3 (Compound 6 h) is an acridone derivative that acts as a Type II DNA topoisomerase (topo II) inhibitor. It specifically inhibits the topo IIα/β subtypes, with an IC50 value of 0.17 μM for topo IIα and 0.23 μM for topo IIβ. This compound elicits significant DNA damage and induces apoptosis by triggering the loss of mitochondrial membrane potential [1].
T79539	Topoisomerase II inhibitor 16	Topoisomerase	DNA Damage/DNA Repair
	TopoisomeraseII inhibitor 16（化合物CT3）是一个选择性的、口服活性的、能够穿透血脑屏障的，并对锥虫拓扑异构酶 II（trypanosomaltopoisomeraseII）产生不可逆抑制的化合物，能够稳定DNA双螺旋与酶之间的复合物。该抑制剂在恰加斯病的研究中显示出潜在应用价值。
T63360	DNA topoisomerase II inhibitor 1
	DNA topoisomerase II inhibitor 1 是 DNA 拓扑异构酶 II 的有效抑制剂，能够将细胞周期停滞在亚 G1 期，并诱导细胞凋亡 (apoptosis) ，具有抗增值作用。
T63526	Topoisomerase I/II inhibitor 4
	Topoisomerase I/II inhibitor 4 是有效的拓扑异构酶 I(Topo I) 和 II(Topo II) 双重抑制剂，对细胞增殖、侵袭和迁移，诱导细胞凋亡 (apoptosis) 具有抑制作用，能够用于研究肝癌。
T13231L	Trovafloxacin mesylate	Others; DNA/RNA Synthesis; Topoisomerase; Antibacterial	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Trovafloxacin是一种广谱氟喹诺酮类抗生素，可阻断 DNA 促旋酶 (DNA gyrase) 和拓扑异构酶 IV (topoisomerase IV) 的活性，也是一种有效的特异性 pannexin 1 通道抑制剂 (PANX1, IC50 = 4 μM)。
T7187	Genz-644282 Genz644282	Topoisomerase	DNA Damage/DNA Repair
	Genz-644282 是一种用于癌症治疗的新型非喜树碱拓扑异构酶 I 抑制剂。
T61990	Topoisomerase I/II inhibitor 3
	Topoisomerase I/II inhibitor 3 (化合物7) 是拓扑异构酶 I (Topo I)和 II (Topo II)的有效双抑制剂。通过抑制 PI3K/Akt/mTOR 信号通路，Topoisomerase I/II inhibitor 3抑制细胞增殖、侵袭和迁移，诱导细胞凋亡(apoptosis)。Topoisomerase I/II inhibitor 3 在肝癌中具有研究价值。
T3181	SW044248	Topoisomerase	DNA Damage/DNA Repair
	SW044248 是非典型拓扑异构酶 I 抑制剂，对 NSCLC 细胞具有选择性毒性。
T3481	Bimolane	Topoisomerase	DNA Damage/DNA Repair
	Bimolane 是一种拓扑异构酶 II 抑制剂。
T4047	Bisantrene CL216942,比生群	Topoisomerase	DNA Damage/DNA Repair
	Bisantrene (CL216942) 是一种具有抗肿瘤活性的蒽基双腙，可靶向作用于真核生物的 II 型拓扑异构酶。它插入并破坏 DNA 的构型，导致 DNA 单链断裂、DNA-蛋白质交联和 DNA 复制的抑制。
T7551	Belotecan hydrochloride CKD-602	Topoisomerase	DNA Damage/DNA Repair
	Belotecan hydrochloride (CKD-602) 是一种合成的水溶性喜树碱衍生物和拓扑异构酶 I 抑制剂，具有潜在的抗肿瘤活性。
T6628	Pirarubicin 吡柔比星,Theprubicin,THP	Topoisomerase; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Microbiology/Virology
	Pirarubicin (Theprubicin) 是一种蒽环类抗生素，是拓扑异构酶 II 抑制剂，可用于各种癌症的研究。
T8747	Levofloxacin hydrochloride	DNA gyrase; Topoisomerase	DNA Damage/DNA Repair
	Levofloxacin hydrochloride 是一种广谱的第三代氟喹诺酮类抗生素，是氧氟沙星的光学活性 L-异构体，具有抗菌活性。左氧氟沙星通过细菌细胞壁扩散并通过抑制 DNA 促旋酶（细菌拓扑异构酶 II）起作用，这是一种 DNA 复制、RNA 转录和细菌 DNA 修复所需的酶。 DNA 促旋酶活性的抑制导致细菌细胞生长受阻。
T7804	Garenoxacin mesylate hydrate Garenoxacin mesylate [USAN],加雷沙星甲磺酸盐,BMS284756 (Mesylate hydrate)	Antibacterial	Microbiology/Virology
	Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) 是一种新型口服 des-fluoro(6) 喹诺酮，具有强抗菌活性，抗呼吸道病原体。
T1060	Flumequine Flumigal,氟甲喹,R-802	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Flumequine (R-802) 是一种喹诺酮类抗生素，对革兰氏阳性菌和革兰氏阴性菌均有效。它是拓扑异构酶 II 抑制剂，抑制细胞分裂，IC50值为 15 μM (3.92 μg/mL)。
T15578	Indotecan NSC-724998,LMP-400	Topoisomerase	DNA Damage/DNA Repair
	Indotecan (LMP-400) 是一种有效的拓扑异构酶 1 抑制剂，对 P388、HCT116和MCF-7 细胞系的IC50值分别为 300、1200和560 nM。
TQ0088	Exatecan Mesylate 依沙替康甲磺酸盐,依喜替康甲磺酸盐,DX8951f	Topoisomerase	DNA Damage/DNA Repair
	Exatecan Mesylate (DX8951f) 是一种 DNA 拓扑异构酶 I 抑制剂，IC50值为 2.2 μM，可研究癌症。
T16522	Phenoxodiol 脱氢雌马酚,Dehydroequol,Idronoxil,Haginin E	Apoptosis; IAP; Caspase; Topoisomerase; p53	Apoptosis; DNA Damage/DNA Repair; Proteases/Proteasome
	Phenoxodiol (Idronoxil) 是合成genestein 的类似物，激活线粒体caspase 系统，抑制XIAP，使癌细胞对fas 介导的凋亡敏感。它在细胞周期的G1/S 期诱导细胞周期阻滞，通过独立于p53的方式上调p21WAF1。它通过稳定可分裂复合物抑制DNA 拓扑异构酶II，从而阻止DNA 复制。

化合物

Topoisomerase II inhibitor 13

Cat.No: T67899

Target: Topoisomerase

Topoisomerase II inhibitor 14

Cat.No: T77650

Target: Apoptosis, Antioxidant, Topoisomerase, NO Synthase

Topoisomerase inhibitor 2

Cat.No: T78717

Target: Topoisomerase

Topoisomerase II inhibitor 11

Cat.No: T64164

Topoisomerase I inhibitor 10

Cat.No: T80968

Target: Topoisomerase

Topoisomerase II inhibitor 15

Cat.No: T79506

Target: Topoisomerase

Topoisomerase I inhibitor 3

Cat.No: T60766

Topoisomerase II inhibitor 8

Cat.No: T60781

Topoisomerase IIα-IN-2

Cat.No: T62224

Topoisomerase I inhibitor 4

Cat.No: T61717

Topoisomerase II inhibitor 9

Cat.No: T63304

Coralyne chloride

Cat.No: T31011

Target: Topoisomerase

Cat.No: T36968

Target: Topoisomerase

Cat.No: T26046

Target: Topoisomerase

Topoisomerase IIα-IN-1

Cat.No: T62223

Topoisomerase I inhibitor 6

Cat.No: T62094

Topoisomerase IV inhibitor 2

Cat.No: T72154

Target: Topoisomerase

Topoisomerase II inhibitor 6

Cat.No: T61017

Topoisomerase II inhibitor 10

Cat.No: T64047

Topoisomerase I inhibitor 2

Cat.No: T60617

Topoisomerase IIα-IN-4

Cat.No: T61431

Topoisomerase II inhibitor 7

Cat.No: T72157

Topoisomerase IV inhibitor 1

Cat.No: T72153

Target: Topoisomerase

Type II topoisomerase inhibitor 1

Cat.No: T61054

Topoisomerase I/II inhibitor 2

Cat.No: T61045

Topoisomerase I inhibitor 7

Cat.No: T62002

Topoisomerase I inhibitor 5

Cat.No: T61501

Topoisomerase IIα-IN-3

Cat.No: T63594

Topoisomerase I inhibitor 8

Cat.No: T62225

Topoisomerase II inhibitor 4

Cat.No: T62887

Topoisomerase I inhibitor 9

Cat.No: T80967

Target: Topoisomerase

Topoisomerase II inhibitor 5

Cat.No: T63068

Topoisomerase II inhibitor 3

Cat.No: T61283

Topoisomerase II inhibitor 16

Cat.No: T79539

Target: Topoisomerase

DNA topoisomerase II inhibitor 1

Cat.No: T63360

Topoisomerase I/II inhibitor 4

Cat.No: T63526

Trovafloxacin mesylate

Cat.No: T13231L

Target: Others, DNA/RNA Synthesis, Topoisomerase, Antibacterial

Cat.No: T7187

Synonym: Genz644282

Target: Topoisomerase

Topoisomerase I/II inhibitor 3

Cat.No: T61990

Cat.No: T3181

Target: Topoisomerase

Cat.No: T3481

Target: Topoisomerase

Cat.No: T4047

Synonym: CL216942,比生群

Target: Topoisomerase

Belotecan hydrochloride

Cat.No: T7551

Synonym: CKD-602

Target: Topoisomerase

Cat.No: T6628

Synonym: 吡柔比星,Theprubicin,THP

Target: Topoisomerase, Antibacterial, Antibiotic, Autophagy

Levofloxacin hydrochloride

Cat.No: T8747

Target: DNA gyrase, Topoisomerase

Garenoxacin mesylate hydrate

Cat.No: T7804

Synonym: Garenoxacin mesylate [USAN],加雷沙星甲磺酸盐,BMS284756 (Mesylate hydrate)

Target: Antibacterial

Cat.No: T1060

Synonym: Flumigal,氟甲喹,R-802

Target: Topoisomerase, Antibacterial, Antibiotic

Cat.No: T15578

Synonym: NSC-724998,LMP-400

Target: Topoisomerase

Exatecan Mesylate

Cat.No: TQ0088

Synonym: 依沙替康甲磺酸盐,依喜替康甲磺酸盐,DX8951f

Target: Topoisomerase

Cat.No: T16522

Synonym: 脱氢雌马酚,Dehydroequol,Idronoxil,Haginin E

Target: Apoptosis, IAP, Caspase, Topoisomerase, p53

Cat. No.	Product Name	Target	Signaling Pathways
TN1037	Groenlandicine	Topoisomerase	DNA Damage/DNA Repair
	Groenlandicine 是来自黄连的一种原小檗碱生物碱，能诱导拓扑异构酶 I 介导的 DNA 裂解。它对人类重组醛糖还原酶(HRAR)具有中度的抑制作用，IC50值为 154.2 μM。
T5S1952	9-Methoxycamptothecin	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	9-Methoxycamptothecin 是从臭味假柴龙树中分离得到的一种天然产物，通过抑制拓扑异构酶起到抗肿瘤作用，具有强效的诱导 G2/M 期细胞和癌细胞凋亡的作用。
TN4660	Niranthin	Anti-infection; HBV; PAFR; Topoisomerase	DNA Damage/DNA Repair; GPCR/G Protein; Microbiology/Virology
	Niranthin 是一种木脂素，具有广泛的药理活性。它是L. donovaniIB 拓扑异构酶的非竞争性抑制剂，可用于研究耐药利什曼病的治疗。
T12651	Rabdosiin (+)-Rabdosiin	Others	Others
	Rabdosiin ((+)-Rabdosiin) 是一种分离自 Rabdosia japonicaHara 中的咖啡酸四聚体，具有抗过敏、抗 HIV 和抑制 DNA 拓扑异构酶作用。
T21065	Artemisitene	Others	Others
	Artemisitene 是青蒿素的氧化形式，是一种抗疟药。青蒿素前体是青蒿素生物合成的重要基础物质，包括青蒿素 B、青蒿素、青蒿酸等。
T1123	Camptothecin NSC-100880,Campathecin,喜树碱,(S)-(+)-Camptothecin,CPT	Apoptosis; Influenza Virus; Topoisomerase; Antibiotic; Antifungal	Apoptosis; DNA Damage/DNA Repair; Microbiology/Virology
	Camptothecin (CPT) 属于生物碱类天然产物，是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂 (IC50=679 nM)，具有特异性。Camptothecin 具有抗肿瘤活性，可以诱导细胞凋亡。
T3332	Isosteviol 异甜菊醇,(-)-Isosteviol	IL Receptor; Potassium Channel; TNF; NF-κB; Reactive Oxygen Species; COX; Topoisomerase	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	Isosteviol ((-)-Isosteviol) 是一种常见的天然甜味剂，属于四环二萜糖苷，是甜菊糖苷通过酸催化水解产生的。它抑制 DNA 聚合酶和 DNA 拓扑异构酶，具有抗菌、抗癌和抗结核作用。
T5853	Rubitecan RFS 2000,鲁比特康,9-Nitrocamptothecin	Topoisomerase	DNA Damage/DNA Repair
	Rubitecan (9-Nitrocamptothecin) 是一种与喜树碱相关的半合成药物，具有有效的抗肿瘤和抗病毒特性。它是一种 DNA 拓扑异构酶 I 抑制剂，以浓度依赖性方式抑制 DNA 拓扑异构酶 I 并在无细胞试验中增加超螺旋 DNA 的比例。
T1166	Ellipticine 玫瑰树碱,NSC 71795,Elliptisine	Topoisomerase	DNA Damage/DNA Repair
	Ellipticine (Elliptisine) 是一种有效的抗肿瘤剂，抑制 DNA 拓扑异构酶 II 活性，对白血病、神经母细胞瘤和胶质母细胞瘤有部分活性。
T6228	Irinotecan CPT-11,Topotecin,伊立替康,(+)-Irinotecan	Topoisomerase; Autophagy	Autophagy; DNA Damage/DNA Repair
	Irinotecan (CPT-11) 是喜树碱的衍生物，是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂。Irinotecan 通过与 Topo I 复合物结合来阻止 DNA 链的重新连接，并导致双链 DNA 断裂和细胞死亡，具有抗肿瘤活性。
T5784	Topotecan NSC 609669,拓扑替康,SKF 104864A	Topoisomerase; Autophagy	Autophagy; DNA Damage/DNA Repair
	Topotecan (NSC-609669) 是一种拓扑异构酶 I 抑制剂，通过抑制 DNA 拓扑异构酶起抗肿瘤作用，可用于治疗卵巢癌。
T4S0797	Berberine 小檗碱,Berberin,Umbellatine,黄连素	Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶，具有抗肿瘤特性。
T5S0761	Nitidine chloride	Apoptosis; ERK; FAK; p38 MAPK; NF-κB; Topoisomerase; STAT; Parasite	Angiogenesis; Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Nitidine chloride 是从Zanthoxylum nitidum (Roxb) DC 中分离得到的，具有抗疟疾活性。它通过多个靶点通路，起抗癌作用，抑制STAT3、DNA 拓扑异构酶1和2A、ERK 和c-Src/FAK 相关信号通路。它通过MAPK 和NF-kB 途径抑制Lps 诱导的炎性细胞因子的产生。
T3S1957	9-amino-CPT 9-氨基喜树碱,Aminocamptothecin,9-amino-2(S)-camptothecin,9-Aminocamptothecin	Topoisomerase	DNA Damage/DNA Repair
	9-amino-CPT (Aminocamptothecin) 是一种拓扑异构酶I 的抑制剂，具有抗肿瘤活性。
T0909	Nalidixic acid 萘啶酸,NSC-82174	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Nalidixic acid (NSC-82174) 是一种喹诺酮类抗生素，对革兰氏阳性和革兰氏阴性细菌有效。它在较低浓度下有抑菌作用，而在较高浓度下有杀菌作用。它抑制 DNA 促旋酶和拓扑异构酶 IV 的亚基，并可逆地阻止易感细菌中的 DNA 复制。
T4614	Ellipticine hydrochloride Ellipticine HCl,NSC 71795 (hydrochloride),玫瑰树碱盐酸盐	Topoisomerase	DNA Damage/DNA Repair
	Ellipticine hydrochloride (NSC-71795 (hydrochloride)) 是一种有效的抗肿瘤剂，抑制 DNA 拓扑异构酶 II 的活性。
T5S0814	Berberine hydrogen sulphate Berberine Bisulfate,硫酸氢黄连素,Umbellatine Sulfate	Antibacterial	Microbiology/Virology
	Berberine hydrogen sulphate (Umbellatine Sulfate) 是一种从几种植物中提取的生物碱，对多种微生物具有抗菌活性，包括革兰氏阳性和革兰氏阴性细菌、真菌和原生动物。
T6567	Levofloxacin Levaquin,Cravit,Tavanic,Fluoroquinolone,左氧氟沙星,(-)-Ofloxacin	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Levofloxacin (Fluoroquinolone) 是合成的氟喹诺酮类抗生素，有抑制细菌DNA 旋转酶的超螺旋活性的作用，能阻止DNA 复制。
T2764	(S)-10-Hydroxycamptothecin 10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	(S)-10-Hydroxycamptothecin (10-HCPT) 是一种从喜树中分离的 DNA 拓扑异构酶 I 抑制剂。它显著诱导细胞凋亡，可研究肝癌、胃癌、结肠癌和白血病。
T0132	Etoposide VP-16,依托泊苷,依托泊甙,VP-16-213	Apoptosis; Mitophagy; Topoisomerase; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Microbiology/Virology
	Etoposide (VP-16-213) 是一种拓扑异构酶 II 的抑制剂，通过与拓扑异构酶 II 和 DNA 形成复合物来抑制 DNA 合成 (IC50=60.3 μM)。Etoposide 具有抗肿瘤活性，可以诱导细胞凋亡、自噬。
T1703	SN-38 7-乙基-10-羟基喜树碱,NK012,伊立替康杂质B,SN 38	DNA/RNA Synthesis; Topoisomerase; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	SN-38 (NK012) 是 DNA 拓扑异构酶 I (Topo I) 抑制剂 Irinotecan 的活性代谢产物，可以抑制 DNA 和 RNA 合成 (IC50=0.077/1.3 μM)。SN-38 具有抗肿瘤活性，可以诱导细胞自噬。
T0461	Berberine chloride Berberine hydrochloride,盐酸小檗碱,Benzodioxide,Natural Yellow 18,盐酸黄连素	Reactive Oxygen Species; Topoisomerase; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine chloride (Natural Yellow 18) 是一种来自小檗科 Hydrastis canadensis L. 的生物碱，也存在于许多其他植物中，常用作抗生素。它对肠胃外的毒性相对较大，但已用于口服用于各种真菌和寄生虫感染以及止泻。
T0486L	Irinotecan Hydrochloride 盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride	Topoisomerase; Autophagy	Autophagy; DNA Damage/DNA Repair
	Irinotecan Hydrochloride (CPT-11 hydrochloride) 是喜树碱半合成衍生物的盐酸盐，是一种拓扑异构酶 I 抑制剂，可研究结肠癌和直肠癌。
T0486	Irinotecan hydrochloride trihydrate Irinotecan HCl Trihydrate,CPT-11 HCl Trihydrate,盐酸伊立替康三水合物	Topoisomerase; Autophagy	Autophagy; DNA Damage/DNA Repair
	Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) 通过抑制拓扑异构酶 1 来防止 DNA 展开，可研究结肠癌和直肠癌。
T2830	Betulinic acid 白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid	Apoptosis; Mitophagy; NF-κB; HIV Protease; Topoisomerase; Endogenous Metabolite; Aminopeptidase; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Betulinic acid (ALS-357) 是从白桦树皮中分离出来的一种五环三萜类天然产物，是真核细胞拓扑异构酶 I 的抑制剂，IC50值为 5 μM，具有抗逆转录病毒、抗疟疾、抗癌和抗炎特性。
TN2105	Proscillaridin A	Topoisomerase	DNA Damage/DNA Repair
	Proscillaridin A 是从Drimia robusta 中提取的一种天然产物。是强力的拓扑异构酶 I 和 II 的抑制剂，IC50值分别为 30 nM 和 100 nM。
T1174	Topotecan hydrochloride SKF 104864A,SKFS 104864A,NSC609699,Nogitecan HCl,NSC 609669,盐酸拓扑替康,Topotecan HCl	Apoptosis; Topoisomerase; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair
	Topotecan hydrochloride (NSC609699) 是一种具有抗癌活性的拓扑异构酶I 抑制剂。
T6407	β-Lapachone 3,4-二氢-2,2-二甲基-2H-萘并[1,2-B]吡喃-5,6-二酮,Beta-Lapachone,NSC-26326,SL-11001,ARQ-501	IDO; Apoptosis; Topoisomerase; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism
	β-Lapachone (ARQ-501) 是一种萘醌类天然产物，是拓扑异构酶 I 抑制剂，通过抑制细胞周期进程来诱导细胞凋亡。
T1020	Doxorubicin hydrochloride Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,盐酸阿霉素,NSC 123127	Apoptosis; Mitophagy; HBV; HIV Protease; Topoisomerase; Antibacterial; Antibiotic; AMPK; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Doxorubicin hydrochloride (Adriamycin) 属于蒽环类抗生素，是人类 DNA 拓扑异构酶 I/II 抑制剂 (IC50=0.8/2.67 μM)。Doxorubicin hydrochloride 具有细胞毒性和抗肿瘤活性。Doxorubicin hydrochloride 可降低 AMPK 及其下游靶蛋白乙酰辅酶 A 羧化酶的磷酸化，还可诱导凋亡和自噬。
T8384	Gatifloxacin hydrochloride AM-1155 (hydrochloride),BMS-206584 (hydrochloride),PD135432 (hydrochloride),加替沙星盐酸盐	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Gatifloxacin hydrochloride (AM-1155 hydrochloride) 是一种氟喹诺酮类抗生素，有广谱抗菌活性。它可抑制大肠杆菌 DNA 解旋酶 (IC50=0.109 μg/ml)和细菌 II 型拓扑异构酶(IC50=13.8 μg/ml) 。它在动物模型中，可研究细菌性结膜炎。
T1521	(±)-10-Hydroxycamptothecin Hydroxy Camptothecine,10-羟基喜树碱,10-Hydroxycamptothecin	Topoisomerase	DNA Damage/DNA Repair
	(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) 是一种从喜树茎木中分离出来的生物碱，抑制拓扑异构酶 I 活性，具有广谱抗肿瘤活性。
T1511	Daunorubicin hydrochloride Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin	Apoptosis; DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Daunorubicin hydrochloride (Rubidomycin hydrochloride) 是一种蒽环类氨基糖苷类抗肿瘤药物，可抑制 DNA 复制和修复以及 RNA 和蛋白质合成。
T1456	Doxorubicin Hydroxydaunorubicin,阿霉素,Adriamycin	Topoisomerase; AMPK	Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Doxorubicin (Adriamycin) 是一种有细胞毒性的蒽环类抗生素，具有肿瘤化疗作用。它抑制DNA 拓扑异构酶 I 和拓扑异构酶 II，IC50分别为0.8 μM 和2.67 μM，从而抑制 DNA 复制。它下调AMPK 的基础磷酸化以及下游 acetyl-CoA 羧化酶。它诱导凋亡和自噬。
TQ0134	Podocarpusflavone A	Topoisomerase	DNA Damage/DNA Repair
	Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.
TN1917	Mauritianin	Topoisomerase	DNA Damage/DNA Repair
	Mauritianin 是一种从 Acalypha indica 的花和叶中分离出来的山柰酚苷，是一种拓扑异构酶 I 抑制剂。Mauritianin 具有细胞保护活性。
T1737	Genistein NPI 031L,三叶草,染料木素,金雀异黄酮	Apoptosis; EGFR; Endogenous Metabolite; Autophagy	Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Metabolism; Tyrosine Kinase/Adaptors
	Genistein (NPI 031L) 是一种大豆异黄酮，是一种多重的酪氨酸激酶抑制剂，通过改变细胞凋亡，细胞周期和血管生成以及抑制转移对多种癌症有化疗作用。
T3339	Sophoridine 5-Epidihydrosophocarpine,槐定碱,Dihydro-5-episophocarpine	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	Sophoridine (Dihydro-5-episophocarpine) 是一种从豆科植物槐豆斜生植物的叶子中分离出来的喹喔啉生物碱。它是胰腺癌的候选药物，诱导细胞凋亡。
T16726	Rebeccamycin	Topoisomerase	DNA Damage/DNA Repair
	Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and topoisomerase II.
T25775	Mansonone E
	Mansonone E is a topoisomerase II inhibitor with cytotoxic and topo inhibitory potencies.
TN2915	3-Acetoxy-27-hydroxy-20(29)-lupen 3-Acetoxy-27-hydroxy-20(29)-lupen-28-oic acid methyl ester	Others	Others
	3α, 27-Dihydroxylupen-20(29)-en-28-oic acid methyl ester is a potent topoisomerase II inhibitor.
TN4422	Lauterine	Topoisomerase	DNA Damage/DNA Repair
	Lauterine is a DNA topoisomerase inhibitor.
TN2861	3,27-Dihydroxy-20(29)-lupen-28-oic acid methyl ester	Others	Others
	3α, 27-Dihydroxylupen-20(29)-en-28-oic acid methyl ester is a potent topoisomerase II inhibitor.
T26953	Carubicin hydrochloride NSC 275649,Karminomycin hydrochloride,Carubicin HCl
	Carubicin HCl is an anthracycline antineoplastic antibiotic. Through intercalates into DNA and interacts with topoisomerase II, Carubicin inhibits DNA replication and repair and RNA and protein synthesis.
T14545	Berberine chloride hydrate Natural Yellow 18 chloride hydrate	Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Parasite; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) 是一种常用作抗生素的生物碱。Berberine chloride hydrate 具有抗肿瘤活性，诱导活性氧 (ROS) 生成并抑制 DNA 拓扑异构酶 (topoisomerase)。
T21328	Carubicin carminomycin,Carminomycin I,Carminomicin I,Antibiotic R 588A,Demethyldaunomycin
	Carubicin is an anthracycline antineoplastic antibiotic isolated from the bacterium Actinomadura carminata. Carubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.
TN1734	Heveaflavone 橡胶树双黄酮	Antioxidant; Topoisomerase	DNA Damage/DNA Repair; oxidation-reduction
	Heveaflavone 抑制拓扑异构酶 I 并清除 DPPH 自由基，具有抗增殖和抗氧化作用。
T14196	Alternariol	Others	Others
	Alternariol (AOH), a mycotoxin synthesized by Alternaria species, displays numerous therapeutic and biological effects, including phytotoxic, cytotoxic, anti-HIV, anti-cancer, and anti-microbial properties. It functions by inhibiting the catalytic activity of topoisomerase I and II enzymes.
T16719	Radicicol 根赤壳菌素,Monorden	HSP	Cytoskeletal Signaling; Metabolism
	Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: 1 μM). Radicicol binds to the ATPase domain of Hsp90 and prevents maturation of Hsp90 clients,
T10238	Aclacinomycin A hydrochloride 盐酸阿柔比星,Aclarubicin hydrochloride	Proteasome	Proteases/Proteasome; Ubiquitination
	Aclacinomycin A (Aclarubicin) hydrochloride is a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II.
TN5133	3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone	HIV Protease; Topoisomerase	DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it shows considerably activity against HIV-1 reverse transcriptase. It exhibits cytotoxic activity against P-388 cell lines, it can inhibit DNA topoisomerase IIα activity, which may be responsible for the observed cytotoxicity.
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天然产物

Cat.No: TN1037

Target: Topoisomerase

9-Methoxycamptothecin

Cat.No: T5S1952

Target: Apoptosis, Topoisomerase

Cat.No: TN4660

Target: Anti-infection, HBV, PAFR, Topoisomerase

Cat.No: T12651

Synonym: (+)-Rabdosiin

Target: Others

Cat.No: T21065

Target: Others

Cat.No: T1123

Synonym: NSC-100880,Campathecin,喜树碱,(S)-(+)-Camptothecin,CPT

Target: Apoptosis, Influenza Virus, Topoisomerase, Antibiotic, Antifungal

Cat.No: T3332

Synonym: 异甜菊醇,(-)-Isosteviol

Target: IL Receptor, Potassium Channel, TNF, NF-κB, Reactive Oxygen Species, COX, Topoisomerase

Cat.No: T5853

Synonym: RFS 2000,鲁比特康,9-Nitrocamptothecin

Target: Topoisomerase

Cat.No: T1166

Synonym: 玫瑰树碱,NSC 71795,Elliptisine

Target: Topoisomerase

Cat.No: T6228

Synonym: CPT-11,Topotecin,伊立替康,(+)-Irinotecan

Target: Topoisomerase, Autophagy

Cat.No: T5784

Synonym: NSC 609669,拓扑替康,SKF 104864A

Target: Topoisomerase, Autophagy

Cat.No: T4S0797

Synonym: 小檗碱,Berberin,Umbellatine,黄连素

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

Nitidine chloride

Cat.No: T5S0761

Target: Apoptosis, ERK, FAK, p38 MAPK, NF-κB, Topoisomerase, STAT, Parasite

Cat.No: T3S1957

Synonym: 9-氨基喜树碱,Aminocamptothecin,9-amino-2(S)-camptothecin,9-Aminocamptothecin

Target: Topoisomerase

Cat.No: T0909

Synonym: 萘啶酸,NSC-82174

Target: Topoisomerase, Antibacterial, Antibiotic

Ellipticine hydrochloride

Cat.No: T4614

Synonym: Ellipticine HCl,NSC 71795 (hydrochloride),玫瑰树碱盐酸盐

Target: Topoisomerase

Berberine hydrogen sulphate

Cat.No: T5S0814

Synonym: Berberine Bisulfate,硫酸氢黄连素,Umbellatine Sulfate

Target: Antibacterial

Cat.No: T6567

Synonym: Levaquin,Cravit,Tavanic,Fluoroquinolone,左氧氟沙星,(-)-Ofloxacin

Target: Topoisomerase, Antibacterial, Antibiotic

(S)-10-Hydroxycamptothecin

Cat.No: T2764

Synonym: 10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT

Target: Apoptosis, Topoisomerase

Cat.No: T0132

Synonym: VP-16,依托泊苷,依托泊甙,VP-16-213

Target: Apoptosis, Mitophagy, Topoisomerase, Antibacterial, Antibiotic, Autophagy

Cat.No: T1703

Synonym: 7-乙基-10-羟基喜树碱,NK012,伊立替康杂质B,SN 38

Target: DNA/RNA Synthesis, Topoisomerase, Autophagy

Berberine chloride

Cat.No: T0461

Synonym: Berberine hydrochloride,盐酸小檗碱,Benzodioxide,Natural Yellow 18,盐酸黄连素

Target: Reactive Oxygen Species, Topoisomerase, Antibacterial, Antibiotic, Autophagy

Irinotecan Hydrochloride

Cat.No: T0486L

Synonym: 盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride

Target: Topoisomerase, Autophagy

Irinotecan hydrochloride trihydrate

Cat.No: T0486

Synonym: Irinotecan HCl Trihydrate,CPT-11 HCl Trihydrate,盐酸伊立替康三水合物

Target: Topoisomerase, Autophagy

Cat.No: T2830

Synonym: 白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid

Target: Apoptosis, Mitophagy, NF-κB, HIV Protease, Topoisomerase, Endogenous Metabolite, Aminopeptidase, Autophagy

Proscillaridin A

Cat.No: TN2105

Target: Topoisomerase

Topotecan hydrochloride

Cat.No: T1174

Synonym: SKF 104864A,SKFS 104864A,NSC609699,Nogitecan HCl,NSC 609669,盐酸拓扑替康,Topotecan HCl

Target: Apoptosis, Topoisomerase, Autophagy

Cat.No: T6407

Synonym: 3,4-二氢-2,2-二甲基-2H-萘并[1,2-B]吡喃-5,6-二酮,Beta-Lapachone,NSC-26326,SL-11001,ARQ-501

Target: IDO, Apoptosis, Topoisomerase, Autophagy

Doxorubicin hydrochloride

Cat.No: T1020

Synonym: Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,盐酸阿霉素,NSC 123127

Target: Apoptosis, Mitophagy, HBV, HIV Protease, Topoisomerase, Antibacterial, Antibiotic, AMPK, Autophagy

Gatifloxacin hydrochloride

Cat.No: T8384

Synonym: AM-1155 (hydrochloride),BMS-206584 (hydrochloride),PD135432 (hydrochloride),加替沙星盐酸盐

Target: Topoisomerase, Antibacterial, Antibiotic

(±)-10-Hydroxycamptothecin

Cat.No: T1521

Synonym: Hydroxy Camptothecine,10-羟基喜树碱,10-Hydroxycamptothecin

Target: Topoisomerase

Daunorubicin hydrochloride

Cat.No: T1511

Synonym: Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin

Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic, Autophagy

Cat.No: T1456

Synonym: Hydroxydaunorubicin,阿霉素,Adriamycin

Target: Topoisomerase, AMPK

Podocarpusflavone A

Cat.No: TQ0134

Target: Topoisomerase

Cat.No: TN1917

Target: Topoisomerase

Cat.No: T1737

Synonym: NPI 031L,三叶草,染料木素,金雀异黄酮

Target: Apoptosis, EGFR, Endogenous Metabolite, Autophagy

Cat.No: T3339

Synonym: 5-Epidihydrosophocarpine,槐定碱,Dihydro-5-episophocarpine

Target: Apoptosis, Topoisomerase

Cat.No: T16726

Target: Topoisomerase

Cat.No: T25775

3-Acetoxy-27-hydroxy-20(29)-lupen

Cat.No: TN2915

Synonym: 3-Acetoxy-27-hydroxy-20(29)-lupen-28-oic acid methyl ester

Target: Others

Cat.No: TN4422

Target: Topoisomerase

3,27-Dihydroxy-20(29)-lupen-28-oic acid methyl ester

Cat.No: TN2861

Target: Others

Carubicin hydrochloride

Cat.No: T26953

Synonym: NSC 275649,Karminomycin hydrochloride,Carubicin HCl

Berberine chloride hydrate

Cat.No: T14545

Synonym: Natural Yellow 18 chloride hydrate

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Parasite, Autophagy

Cat.No: T21328

Synonym: carminomycin,Carminomycin I,Carminomicin I,Antibiotic R 588A,Demethyldaunomycin

Cat.No: TN1734

Synonym: 橡胶树双黄酮

Target: Antioxidant, Topoisomerase

Cat.No: T14196

Target: Others

Cat.No: T16719

Synonym: 根赤壳菌素,Monorden

Target: HSP

Aclacinomycin A hydrochloride

Cat.No: T10238

Synonym: 盐酸阿柔比星,Aclarubicin hydrochloride

Target: Proteasome

3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone

Cat.No: TN5133

Target: HIV Protease, Topoisomerase

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