H2N-PEG8-Hydrazide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
6,7-Dihydro-5H-quinolin-8-one is a synthetic intermediate.1,2It has been used in the synthesis of tetrahydropyridoazepinones and thiosemicarbazones with anticancer activity.