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顶部生物活性储存和溶解信息计算器

Anti-SUMO4 Antibody (4W157)

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Anti-SUMO4 Antibody (4W157)
产品编号 TMAC-03915
别名 SUMO4_HUMAN, SUMO 4, SMT3H4, SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae), SMT3 suppressor of mif two 3 homolog 2, Small ubiquitin-related modifier 4, Small ubiquitin-like protein 4, Small ubiquitin like modifier 4 protein, IDDM5, dJ281H8.4

Anti-SUMO4 Antibody (4W157) 是一种 Rabbit 抗体，靶向 SUMO4。Anti-SUMO4 Antibody (4W157) 可用于 WB,ICC/IF,IP,FCM。

Anti-SUMO4 Antibody (4W157)

Anti-SUMO4 Antibody (4W157)

Rating icon 还可以
Anti-SUMO4 Antibody (4W157)
产品编号 TMAC-03915 别名 SUMO4_HUMAN, SUMO 4, SMT3H4, SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae), SMT3 suppressor of mif two 3 homolog 2, Small ubiquitin-related modifier 4, Small ubiquitin-like protein 4, Small ubiquitin like modifier 4 protein, IDDM5, dJ281H8.4

Anti-SUMO4 Antibody (4W157) 是一种 Rabbit 抗体，靶向 SUMO4。Anti-SUMO4 Antibody (4W157) 可用于 WB,ICC/IF,IP,FCM。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍

生物活性
产品描述
Anti-SUMO4 Antibody (4W157) is a Rabbit antibody targeting SUMO4. Anti-SUMO4 Antibody (4W157) can be used in WB,ICC/IF,IP,FCM.
别名SUMO4_HUMAN, SUMO 4, SMT3H4, SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae), SMT3 suppressor of mif two 3 homolog 2, Small ubiquitin-related modifier 4, Small ubiquitin-like protein 4, Small ubiquitin like modifier 4 protein, IDDM5, dJ281H8.4
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of SUMO4 on different lysates using anti-SUMO4 antibody at 1/1,000 dilution. Positive control: Lane 1: 293T, Lane 2: Jurkat.
2. ICC staining SUMO4 in 293 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
3. ICC staining SUMO4 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
4. ICC staining SUMO4 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
5. ICC staining SUMO4 in RH-35 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
6. Flow cytometric analysis of 293 cells with SUMO4 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
应用
WB
ICC/IF
IP
FCM
推荐剂量
WB: 1:1000-2000; ICC/IF: 1:100-500; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2, SUMO-3 and SUMO-4, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Ubiquitin and SUMO proteins utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins for a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2, SUMO-3 and SUMO-4 proteins localize to the nucleus. In contrast to the other SUMO proteins, SUMO-4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90, which may impair processing to mature form and conjugation to substrates. It is suggested that defects in the gene that encodes for the SUMO-4 protein may be involved in the pathogenesis of type I diabetes.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
Q6EEV6
化学信息
分子量Theoretical: 11 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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