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Anti-CD200 Antibody (2H839)
还可以产品编号 TMAY-03079
Anti-CD200 Antibody (2H839) 是一种 Rabbit 抗体，靶向 CD200。Anti-CD200 Antibody (2H839) 可用于 FCM。
Anti-CD200 Antibody (2H839)
Anti-CD200 Antibody (2H839)
还可以产品编号 TMAY-03079
Anti-CD200 Antibody (2H839) 是一种 Rabbit 抗体，靶向 CD200。Anti-CD200 Antibody (2H839) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CD200 Antibody (2H839) is a Rabbit antibody targeting CD200. Anti-CD200 Antibody (2H839) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 2H839 |
| 交叉反应 | Mouse |
| 验证活性 | Flow cytometric analysis of CD200 expression on spleen lymphocytes. BALB/c splenocytes were stained with Mouse CD200 Monoclonal Ab, then a FITC-conjugated second step antibody. The histogram were derived from the gated events based on light scattering characteristics of lymphocytes. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD200 (rM CD200; TMPY-01160; O54901.1; Met 1-Gly 232). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through the CD200:CD200R axis have been shown to play an important role in the regulation of anti-tumor immunity, and overexpression of CD200 has been reported in a number of malignancies, including CLL, as well as on cancer stem cells. The role of CD200-CD200R signaling in immune regulation of the central nervous system has become a popular field of research in recent years. Many studies have shown that there is a close correlation between CD200-CD200R, microglia activation, and Parkinson's disease (PD). The ability of CD200 to suppress myeloid cell activation is critical for maintaining normal tissue homeostasis but may also enhance the survival of migratory neoplastic cells. CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 has been characterized as an important immunoregulatory molecule, increased expression of which can lead to decreased transplant rejection, autoimmunity, and allergic disease. Elevated CD200 expression has been reported to be associated with poor prognosis in some human malignancies. Besides, CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/PE |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Mouse CD200 protein (50074-M08H) |
| 抗原种属 | Mouse |
| 研究领域 | Neuroinflammation, Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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