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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-ATXN1 Monoclonal Antibody (6H860)

Synonyms: SCA1, D6S504E, ATX1
货号 TMAT-0132 一键复制产品信息
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Anti-ATXN1 Monoclonal Antibody (6H860) 是一种 Mouse 抗体，靶向 ATXN1。Anti-ATXN1 Monoclonal Antibody (6H860) 可用于 WB,IHC,FCM。

Anti-ATXN1 Monoclonal Antibody (6H860)

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Rating icon 还可以
货号 TMAT-0132

别名 SCA1, D6S504E, ATX1

Anti-ATXN1 Monoclonal Antibody (6H860) 是一种 Mouse 抗体，靶向 ATXN1。Anti-ATXN1 Monoclonal Antibody (6H860) 可用于 WB,IHC,FCM。

Anti-ATXN1 Monoclonal Antibody (6H860)
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产品介绍

生物活性
产品描述
Anti-ATXN1 Monoclonal Antibody (6H860) is a Mouse antibody targeting ATXN1. Anti-ATXN1 Monoclonal Antibody (6H860) can be used in WB,IHC,FCM.
别名
SCA1, D6S504E, ATX1
Ig Type
IgG1
克隆号
6H860
反应种属
Human,Mouse,Rat，Monkey
应用WBIHCFCM
推荐剂量
WB: 1/500-1/2000; IHC: 1/100-1/500; FCM: 1/200-1/400
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide
浓度1 mg/ml
研究背景The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 40-83 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). Alternative splicing results in multiple transcript variants, with one variant encoding multiple distinct proteins, ATXN1 and Alt-ATXN1, due to the use of overlapping alternate reading frames.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of human ATXN1 (AA: 645-815) expressed in E. Coli.
抗原种属
Human
基因名称
ATXN1
基因ID
6310
蛋白名称
Ataxin-1
Uniprot ID
P54253
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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