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Anti-CASP2 Antibody (8H206)
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产品编号 TMAC-00580
别名 Protease ICH-1, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, ICH1 NEDD2, EC 3.4.22.55, Caspase-2, Caspase2, CASP-2
Anti-CASP2 Antibody (8H206) 是一种 Rabbit 抗体，靶向 CASP2。Anti-CASP2 Antibody (8H206) 可用于 WB,ICC/IF,IHC,FCM。
Anti-CASP2 Antibody (8H206)
Anti-CASP2 Antibody (8H206)
还可以产品编号 TMAC-00580 别名 Protease ICH-1, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, ICH1 NEDD2, EC 3.4.22.55, Caspase-2, Caspase2, CASP-2
Anti-CASP2 Antibody (8H206) 是一种 Rabbit 抗体，靶向 CASP2。Anti-CASP2 Antibody (8H206) 可用于 WB,ICC/IF,IHC,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,485 | 5日内发货 | |
| 100 μL | ¥ 2,490 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-CASP2 Antibody (8H206) is a Rabbit antibody targeting CASP2. Anti-CASP2 Antibody (8H206) can be used in WB,ICC/IF,IHC,FCM. |
| 别名 | Protease ICH-1, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, ICH1 NEDD2, EC 3.4.22.55, Caspase-2, Caspase2, CASP-2 |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse |
| 验证活性 | 1. Western blot analysis of Caspase-2 on 293 cell lysate using anti-Caspase-2 antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-Caspase-2 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Caspase-2 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-Caspase-2 antibody. Counter stained with hematoxylin. 5. ICC staining Caspase-2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining Caspase-2 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. Flow cytometric analysis of Jurkat cells with Caspase-2 antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Caspase-2 (Nedd2, ICH-1) is an aspartate-specific cysteine protease that is activated in response to various apoptotic stimuli. Caspase-2 is unique among the caspases in that it has features of both upstream caspases (long prodomain) and downstream caspases (DEXD substrate specificity). Caspase-2 is highly expressed in the brain during development, and is expressed at low levels in adult tissue. Specifically, caspase-2 localizes to the mitochondria, the Golgi, the cytoplasm, and the nucleus. Caspase-2 exists as two isoforms, caspase-2L and caspase-2S, which are produced by alternative splicing and differ in their N and C-termini. Caspase-2L acts as a positive regulator of apoptosis, whereas caspase-2S functions as a negative regulator of apoptosis. Following apoptotic stimuli, the caspase-2L precursor undergoes cleavage at Asp-153 to produce a fragment (p30). The p30 fragment undergoes further cleavage to generate a fragment containing amino acids 153-308 (p18) and a fragment containing amino acids 317-435 (p13 or p14). As apoptosis progresses, the p13 (p14) fragment can undergo further processing to yield a fragment containing amino acids 331-435 (p12). |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 48/30/12 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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