购物车
全部删除
  • TargetMol
    您的购物车当前为空
前往下单页继续购物
顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-MUC-4 Antibody (8H436)

一键复制产品信息
Rating icon 还可以
货号 TMAB-09097

Anti-MUC-4 Antibody (8H436) 是一种 Rabbit 抗体，靶向 MUC-4。Anti-MUC-4 Antibody (8H436) 可用于 IHC-P,IHC-Fr,IF。

Anti-MUC-4 Antibody (8H436)

Anti-MUC-4 Antibody (8H436)

一键复制产品信息
Rating icon 还可以
货号 TMAB-09097

Anti-MUC-4 Antibody (8H436) 是一种 Rabbit 抗体，靶向 MUC-4。Anti-MUC-4 Antibody (8H436) 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
25 μL
¥ 795
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,480
5日内发货
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
实验操作小课堂
常见问题解答
查看更多
资源下载:
产品操作手册

产品介绍

生物活性
产品描述
Anti-MUC-4 Antibody (8H436) is a Rabbit antibody targeting MUC-4. Anti-MUC-4 Antibody (8H436) can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
克隆号
8H436
反应种属
Human
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Membrane; Single-pass membrane protein (Potential). Secreted. Note=Isoforms lacking the Cys-rich region, EGF-like domains and transmembrane region are secreted. Secretion occurs by splicing or proteolytic processing. Mucin-4 beta chain: Cell membrane; Single-pass membrane protein.Mucin-4 alpha chain: Secreted.Isoform 3, 17: Cell membrane; Single-pass membrane protein. Isoform 11, 15: Secreted.
组织特异性Expressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small intestine, colon, testis, prostate, ovary, uterus, placenta, and mammary and salivary glands. Expressed in carcinomas arising from some of these epithelia, such as lung cancers, squamous cell carcinomas of the upper aerodigestive tract, mammary carcinomas, biliary tract, colon, and cervix cancers. Minimally or not expressed in the normal pancreas or chronic pancreatitis, but is highly expressed in pancreatic tumors and pancreatic tumor cell lines.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq].
抗原信息
免疫原
KLH conjugated synthetic peptide: human MUC-4
抗原种属
Human
基因名称
MUC4
基因ID
4585
蛋白名称
Mucin-4
Uniprot ID
Q99102
功能
May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.
化学信息
分子量Theoretical: 80 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
Related Tags: buy Anti-MUC-4 Antibody (8H436) | purchase Anti-MUC-4 Antibody (8H436) | Anti-MUC-4 Antibody (8H436) cost | order Anti-MUC-4 Antibody (8H436) | Anti-MUC-4 Antibody (8H436) molecular weight