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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-MARCH8 Polyclonal Antibody

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货号 TMAB-08611

Anti-MARCH8 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MARCH8。Anti-MARCH8 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-MARCH8 Polyclonal Antibody

Anti-MARCH8 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-08611

Anti-MARCH8 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MARCH8。Anti-MARCH8 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-MARCH8 Polyclonal Antibody is a Rabbit antibody targeting MARCH8. Anti-MARCH8 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Chicken,Pig,Cow,Horse,Rabbit,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:50-200
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasmic vesicle membrane. Lysosome membrane. Early endosome membrane.
组织特异性Broadly expressed. Present in immature dendritic cells (at protein level).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. MARCH8 (membrane-associated ring finger (C3HC4) 8), also known as MIR or RNF178 (RING finger protein 178), is a 291 amino acid multi-pass membrane protein that localizes to vesicle membranes and contains one RING-CH-type zinc finger. Expressed in a variety of tissues, including immature dendritic cells, MARCH8 functions as an E3 ubiquitin ligase that is thought to regulate immune responses by promoting the ubiquitination and subsequent degradation of target proteins, such as B7-2 and CD71.
抗原信息
免疫原
KLH conjugated synthetic peptide: human MARCH8
抗原种属
Human
基因名称
MARCHF8
基因ID
220972
蛋白名称
E3 ubiquitin-protein ligase MARCHF8
Uniprot ID
Q5T0T0
功能
E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.
化学信息
分子量Theoretical: 33 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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