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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-PIWIL1 Antibody (8H399)

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货号 TMAB-11472

Anti-PIWIL1 Antibody (8H399) 是一种 Rabbit 抗体，靶向 PIWIL1。Anti-PIWIL1 Antibody (8H399) 可用于 FCM。

Anti-PIWIL1 Antibody (8H399)

Anti-PIWIL1 Antibody (8H399)

一键复制产品信息
Rating icon 还可以
货号 TMAB-11472

Anti-PIWIL1 Antibody (8H399) 是一种 Rabbit 抗体，靶向 PIWIL1。Anti-PIWIL1 Antibody (8H399) 可用于 FCM。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,380
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-PIWIL1 Antibody (8H399) is a Rabbit antibody targeting PIWIL1. Anti-PIWIL1 Antibody (8H399) can be used in FCM.
Ig Type
IgG
克隆号
8H399
反应种属
Human (predicted:Mouse,Rat)
应用FCM
推荐剂量
FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Also present in chromatoid body.
组织特异性Detected in most fetal and adult tissues. Expressed in testes, specifically in germline cells; detected in spermatocytes and spermatids during spermatogenesis. Increased expression in testicular tumors originating from embryonic germ cells with retention of germ cells phenotype. No expression in testicular tumors of somatic origin, such as Sertoli cell and Leydig cell tumors. Overexpressed in gastric cancer cells. Isoform 3 is ubiquitously expressed, and specifically in CD34+ hematopoietic progenitor cells but not in more differentiated cells.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons.
抗原信息
免疫原
A synthesized peptide: human Piwi like protein 1
抗原种属
Human
基因名称
PIWIL1
基因ID
9271
蛋白名称
Piwi-like protein 1
Uniprot ID
Q96J94
功能
Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability. Isoform 3 may be a negative developmental regulator.
化学信息
分子量Theoretical: 99 kDa. Actual: 99 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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