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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-LRP6 Antibody (6H830)

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货号 TMAB-08403

Anti-LRP6 Antibody (6H830) 是一种 Rabbit 抗体，靶向 LRP6。Anti-LRP6 Antibody (6H830) 可用于 WB。

Anti-LRP6 Antibody (6H830)

Anti-LRP6 Antibody (6H830)

一键复制产品信息
Rating icon 还可以
货号 TMAB-08403

Anti-LRP6 Antibody (6H830) 是一种 Rabbit 抗体，靶向 LRP6。Anti-LRP6 Antibody (6H830) 可用于 WB。

规格价格库存数量
25 μL
¥ 795
5日内发货
50 μL
¥ 1,385
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-LRP6 Antibody (6H830) is a Rabbit antibody targeting LRP6. Anti-LRP6 Antibody (6H830) can be used in WB.
Ig Type
IgG
克隆号
6H830
反应种属
Human
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD.
组织特异性Widely co-expressed with LRP5 during embryogenesis and in adult tissues.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation.
抗原信息
免疫原
A synthesized peptide: human LRP6
抗原种属
Human
基因名称
LRP6
基因ID
4040
蛋白名称
Low-density lipoprotein receptor-related protein 6
Uniprot ID
O75581
功能
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation.
化学信息
分子量Theoretical: 180 kDa. Actual: 180-230 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

  • 稀释 计算器
  • 配液 计算器
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