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Anti-LRP6 Antibody (6H830)

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货号 TMAB-08403

Anti-LRP6 Antibody (6H830) 是一种 Rabbit 抗体，靶向 LRP6。Anti-LRP6 Antibody (6H830) 可用于 WB。

Anti-LRP6 Antibody (6H830)

Anti-LRP6 Antibody (6H830)

一键复制产品信息
Rating icon 还可以
货号 TMAB-08403

Anti-LRP6 Antibody (6H830) 是一种 Rabbit 抗体，靶向 LRP6。Anti-LRP6 Antibody (6H830) 可用于 WB。

规格价格库存数量
25 μL
¥ 795
5日内发货
50 μL
¥ 1,385
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-LRP6 Antibody (6H830) is a Rabbit antibody targeting LRP6. Anti-LRP6 Antibody (6H830) can be used in WB.
Ig Type
IgG
克隆号
6H830
反应种属
Human
验证活性
25 μg total protein per lane of various lysates (see on figure) probed with LRP6 monoclonal antibody, unconjugated (TMAB-08403) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min.
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD.
组织特异性Widely co-expressed with LRP5 during embryogenesis and in adult tissues.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation.
抗原信息
免疫原
A synthesized peptide: human LRP6
抗原种属
Human
基因名称
LRP6
基因ID
4040
蛋白名称
Low-density lipoprotein receptor-related protein 6
Uniprot ID
O75581
功能
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation.
化学信息
分子量Theoretical: 180 kDa. Actual: 180-230 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

  • 稀释 计算器
  • 配液 计算器
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