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Anti-HMGCR Antibody (4H804)

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Anti-HMGCR Antibody (4H804)
产品编号 TMAC-01982
别名 HMGCR, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Anti-HMGCR Antibody (4H804) 是一种 Rabbit 抗体，靶向 HMGCR。Anti-HMGCR Antibody (4H804) 可用于 WB,IP。

Anti-HMGCR Antibody (4H804)

Anti-HMGCR Antibody (4H804)

Rating icon 还可以
Anti-HMGCR Antibody (4H804)
产品编号 TMAC-01982 别名 HMGCR, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Anti-HMGCR Antibody (4H804) 是一种 Rabbit 抗体，靶向 HMGCR。Anti-HMGCR Antibody (4H804) 可用于 WB,IP。

规格价格库存数量
50 μL
¥ 1,485
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-HMGCR Antibody (4H804) is a Rabbit antibody targeting HMGCR. Anti-HMGCR Antibody (4H804) can be used in WB,IP.
别名HMGCR, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of HMGCR on Hela cells lysates using anti-HMGCR antibody at 1/1,000 dilution.
应用
WB
IP
推荐剂量
WB: 1:1000-2000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The human enzyme hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) limits the rate of cholesterol synthesis, a necessary process for cellular growth, in liver tissue. Phosphorylation of HMGCR inactivates the enzyme, which occurs via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from the product of the reductase reaction. Inhibitors of HMGCR (statins) exert inflammatory effects and decrease the frequency of cardiovascular events by lowering plasma cholesterol. Additionally, intermediate products along the pathway catalyzed by HMGCR, which modulate signal transducing proteins such as Ras, provide possible ties between HMGCR regulation and new chemotherapeutic methods.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P04035
化学信息
分子量Theoretical: 97 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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