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Anti-CYP2D6 Antibody (8H168)

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Anti-CYP2D6 Antibody (8H168)
产品编号 TMAC-01070
别名 Xenobiotic monooxygenase, P450DB1, P450C2D, P450 DB1, Microsomal monooxygenase, Flavoprotein linked monooxygenase, Debrisoquine 4 hydroxylase, Cytochrome P450 family 2 subfamily D polypeptide 6, Cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 DB1, CYPIID6, CYP2DL1, CYP2D8P2, CYP2D7P2, CYP2D7BP, CYP2D7AP, CYP2D6, CYP2D, CPD6

Anti-CYP2D6 Antibody (8H168) 是一种 Rabbit 抗体，靶向 CYP2D6。Anti-CYP2D6 Antibody (8H168) 可用于 WB,ICC/IF,IHC,FCM。

Anti-CYP2D6 Antibody (8H168)

Anti-CYP2D6 Antibody (8H168)

Rating icon 还可以
Anti-CYP2D6 Antibody (8H168)
产品编号 TMAC-01070 别名 Xenobiotic monooxygenase, P450DB1, P450C2D, P450 DB1, Microsomal monooxygenase, Flavoprotein linked monooxygenase, Debrisoquine 4 hydroxylase, Cytochrome P450 family 2 subfamily D polypeptide 6, Cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 DB1, CYPIID6, CYP2DL1, CYP2D8P2, CYP2D7P2, CYP2D7BP, CYP2D7AP, CYP2D6, CYP2D, CPD6

Anti-CYP2D6 Antibody (8H168) 是一种 Rabbit 抗体，靶向 CYP2D6。Anti-CYP2D6 Antibody (8H168) 可用于 WB,ICC/IF,IHC,FCM。

规格价格库存数量
50 μL
¥ 1,485
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍

生物活性
产品描述
Anti-CYP2D6 Antibody (8H168) is a Rabbit antibody targeting CYP2D6. Anti-CYP2D6 Antibody (8H168) can be used in WB,ICC/IF,IHC,FCM.
别名Xenobiotic monooxygenase, P450DB1, P450C2D, P450 DB1, Microsomal monooxygenase, Flavoprotein linked monooxygenase, Debrisoquine 4 hydroxylase, Cytochrome P450 family 2 subfamily D polypeptide 6, Cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 DB1, CYPIID6, CYP2DL1, CYP2D8P2, CYP2D7P2, CYP2D7BP, CYP2D7AP, CYP2D6, CYP2D, CPD6
Ig Type
IgG
交叉反应
Human
验证活性
1. Western blot analysis of Cytochrome P450 2D6 on HepG2 cell using anti-Cytochrome P450 2D6 antibody at 1/1,000 dilution.
2. Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Cytochrome P450 2D6 antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Cytochrome P450 2D6 antibody. Counter stained with hematoxylin.
4. ICC staining Cytochrome P450 2D6 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
5. ICC staining Cytochrome P450 2D6 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
6. Flow cytometric analysis of SW480 cells with Cytochrome P450 2D6 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
应用
WB
ICC/IF
IHC
FCM
推荐剂量
WB: 1:500-2000; IHC: 1:50-200; ICC/IF: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The P450II family comprises at least five subfamilies, designated A through E by the system of nomenclature recommended by an international committee. The P450IID subfamily comprises at least two genes in the rat, one of which is highly specific for debrisoquine 4-hydroxylase activity. An association of this gene with lung cancer has been found. Enhanced CYP2D6 activity has been related to malignancies of the bladder, liver, pharynx and stomach, and especially to cigarette-smoking-induced lung cancer. The data suggests that enhanced CYP2D6-mediated metabolism of one or more dietary and other environmental agents, to form a reactive intermediate, plays a role in cancer initiation and/or promotion in various tissues. CYP2D6 polymorphism, which is responsible for the variation in metabolism of debrisoquine 4-hydroxylase, is important in the metabolism of more than 30 drugs and environmental chemicals, including as much as 20% of all commonly prescribed drugs. The gene which encodes CYP2D6 maps to human chromosome 22q13.1.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P10635
化学信息
分子量Theoretical: 56 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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