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Anti-B7-H3 Antibody (8G959)
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产品编号 TMAH-00187
别名 UNQ309, PSEC0249, PRO352, CD276, B7-H3, B7 homolog 3, 4Ig-B7-H3
Anti-B7-H3 Antibody (8G959) 是一种抗体，靶向 B7-H3。Anti-B7-H3 Antibody (8G959) 可用于 ELISA。
Anti-B7-H3 Antibody (8G959)
Anti-B7-H3 Antibody (8G959)
还可以产品编号 TMAH-00187 别名 UNQ309, PSEC0249, PRO352, CD276, B7-H3, B7 homolog 3, 4Ig-B7-H3
Anti-B7-H3 Antibody (8G959) 是一种抗体，靶向 B7-H3。Anti-B7-H3 Antibody (8G959) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,190 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-B7-H3 Antibody (8G959) is an antibody targeting B7-H3. Anti-B7-H3 Antibody (8G959) can be used in ELISA. |
| 别名 | UNQ309, PSEC0249, PRO352, CD276, B7-H3, B7 homolog 3, 4Ig-B7-H3 |
| Ig Type | hIgG1 |
| 克隆号 | 8G959 |
| 交叉反应 | Human, Cynomolgus |
| 验证活性 | 1. The Binding Activity of Human CD276 with Anti-CD276 recombinant antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized human CD276 at 2 μg/mL can bind Anti-CD276 recombinant antibody. The EC50 is 4.299-5.373 ng/mL. 2. The Binding Activity of Human CD276 with Anti-CD276 recombinant antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized human CD276 at 2 μg/mL can bind Anti-CD276 recombinant antibody. The EC50 is 47.12-54.16 ng/mL. 3. Overlay Peak curve showing MCF7 cells stained with TMAH-00187MA1HU (red line) at 1:100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10^6 cells) for 45min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4°C.Control antibody (green line) was human IgG (1ug/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| 应用 | ELISA |
| 推荐剂量 | ELISA:1:5000-1:50000. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 研究背景 | Earlier studies found that B7H3 (also known as B7H3) promotes the activation of T cells. Chapoval et al. confirmed that in the presence of anti-CD3 antibodies, B7H3 can promote the proliferation of CD4 and CD8+ T cells and selectively promote the secretion of IFN-γ. And B7H3 transfection into tumor cells can enhance the killing ability of CTL. Further research found that only TLT-2 transgenic cells could bind to mouse B7H3 with high affinity, and TLT-2 was determined to be the receptor molecule of B7H3. Moreover, Hashiguchi et al. confirmed that the B7H3-TLT-2 pathway enhanced T cell activation. However, Leitner et al. did not find the specific binding of B7H3 to TLT-2 by flow cytometry, therefore, the exact receptor molecule of B7H3 is still unclear. On the other hand, studies have found that B7H3 can also suppress T-cell immune responses. Some studies have shown that B7H3 can inhibit human and mouse T cells by activating or inhibiting NFTA (nuclear factor for activated T cells), NF-KB (nuclear factor kB) and AP-1 (activator protein-1) pathways. activation. In addition, results have demonstrated that B7H3 may inhibit T cell immune responses by inhibiting the activity of Thl. The study of Leiner et al. also found that B7H3 can down-regulate the secretion of IL-2 in T cells to inhibit the activity of T cells. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human CD276 Protein |
| 抗原种属 | Human |
| 基因ID | 80381 |
| Uniprot ID | |
| 研究领域 | Cancer, Immunology, Stem cells |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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