Anti-JMJD2A Antibody (6H812) is a Rabbit antibody targeting JMJD2A. Anti-JMJD2A Antibody (6H812) can be used in WB,IHC-P,IHC-Fr,IP,IF.

IgG

6H812

Human,Mouse,Rat

WB: 1:1000-2000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; IP: 1:20-50; IF: 1:100-200

Monoclonal

A synthesized peptide: human KDM4A

Human

KDM4A

Lysine-specific demethylase 4A

Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.