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Search Results for " collagen "

139

抑制剂 & 化合物

42

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10861	Collagen proline hydroxylase inhibitor-1	Others	Others
	Collagen proline hydroxylase inhibitor-1 具有抗纤维增生活性。
T80025	Bovine Type II Collagen Collagen, Type II, Immunization Grade
	Type II collagen 是一种治疗骨关节炎的有效蛋白质。在减缓小鼠胶原性关节炎疼痛和炎症方面，Type II collagen 显示了显著的效果。
T10862	Collagen proline hydroxylase inhibitor	Others	Others
	Collagen proline hydroxylase inhibitor is an inhibitor collagen proline hydroxylase and useful for antifibrotic proliferative agents.
TP2301	type II collagen fragment	Others	Others
	Type II collagen is composed of a triple helix of three identical α chains. These molecules associate to form a fibril that is stabilized by intermolecular crosslinks1. Damage to the fibrillar meshwork, made up of primarily type II collagen (z 90–95%), ma
TP1643	Alpha 1(I) Collagen (614-639), human
	This is a peptide inhibitor of collagen fibrillar matrix assembly.
TP2452	Collagen type IV alpha1 (531-543) Hep III peptide,Gefyfdlrlkgdk
	Collagen type IV alpha1 (531-543) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of type IV collagen and plays a role in angiogenesis.
T60303	Collagen-IN-1
	Collagen-IN-1 (compound 3) is an ortho-carbonyl hydroquinone derivative exhibiting selective inhibition of collagen. It non-competitively inhibits agonist-induced platelet aggregation, with an IC50 value of 1.77 μM. Collagen-IN-1 effectively reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelets. This compound holds promise for research into platelet-related thrombosis diseases [1].
T7692	2,4-DPD	HIF	Angiogenesis; Chromatin/Epigenetic
	2,4-DPD 是氧感应酶 HIF-α 脯氨酰羟化酶 (HIF-PH) 的竞争性抑制剂。
T10860	Col003	HSP	Cytoskeletal Signaling; Metabolism
	Col003 是一种选择性和有效的 Hsp47 抑制剂，可竞争性结合 Hsp47 上的胶原蛋白结合位点，IC50为1.8 μM。它通过破坏胶原蛋白三螺旋的稳定性来抑制胶原蛋白的分泌，可用于肺纤维化的相关研究。
T16886	Sinefungin Adenosyl-Ornithine,西奈芬净,A-9145,Antibiotic 32232RP	Others; Histone Methyltransferase; Antibiotic; Antifungal	Chromatin/Epigenetic; Microbiology/Virology; Others
	Sinefungin (Adenosyl-Ornithine) 是病毒粒子mRNA (鸟嘌呤-7-)-甲基转移酶、 mRNA (核苷-2'-)-甲基转移酶和病毒增殖的有效抑制剂。它还抑制SET7/9，通过抑制H3K4甲基化来改善肾纤维化。
T2057	BVT 2733	Dehydrogenase	Metabolism
	BVT 2733 是具有口服活性的、强效的、非甾体类11β-HSD1选择性抑制剂。它对小鼠 11β-HSD1 酶的作用 (IC50:96 nM) 比对人 11β-HSD1 酶 (IC50:3341 nM) 的作用强。它对关节炎和肥胖相关疾病具有潜在的研究价值。
TP1328	TB500	Others	Others
	TB500 是一种胸腺素β4活性区域的合成分子。它可促进内皮细胞分化，角质形成细胞迁移，真皮组织中的血管生成，胶原沉积和减少炎症。
T21616	L-006235 L 006235	Cysteine Protease	Proteases/Proteasome
	L-006235 是一种口服有活性的、可逆的cathepsin K 选择性抑制剂，在骨吸收试验中的IC50值为 5 nM。它能够抑制胶原蛋白降解，并较少骨质流失。
T11699	J-113863	CCR	Immunology/Inflammation; Microbiology/Virology
	J-113863 是选择性的 CCR1 (CD18)拮抗剂，有抗炎作用，对人和小鼠 CCR1受体的 IC50值分别为 0.9 和 5.8 nM。它是人 CCR3的强效拮抗剂，还是小鼠 CCR3的弱效拮抗剂，IC50分别为 0.58 和 460 nM。
T4283	SRI-011381	TGF-beta/Smad	Stem Cells
	SRI011381 是口服具有活力的 TGF-β信号通路的激活剂，具有神经保护活性。
T6576	Malotilate Malotilatum,NKK 105,马洛替酯,Kantec	Lipoxygenase	Metabolism
	Malotilate (Kantec) 是一种抗纤维化物质，是一种口服活性的促肝药，可选择性抑制5-lipoxygenase (5-LOX)(IC50=4.7 μM)。它通过降低肝脏乙醛水平并防止转铁蛋白保留在肝细胞中，从而预防了酒精-吡唑肝炎中肝细胞损伤的发展。
T9195	SHR0302 ARQ252	Apoptosis; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	SHR0302 (ARQ252) 是一种具有口服活性的 JAK 抑制剂。它对 JAK1的结合力是 JAK2的 10 倍以上，是 JAK3的 77 倍，是 Tyk2的 420 倍。它抑制JAK1-STAT3磷酸化并诱导肝星状细胞凋亡，具有抗增殖和抗炎作用。
T5329	Trandolapril	Angiotensin-converting Enzyme (ACE)	Metabolism
	Trandolapril 是 Trandolaprilat 的前体药物。Trandolapril 是一种口服血管紧张素转换酶抑制剂，在高血压和充血性心力衰竭及心肌梗死领域有研究价值。
TP1158	Copper tripeptide [N2-(N-甘氨酰-L-组氨酰)-L-赖氨酸]铜,GHK-Cu	Others; Endogenous Metabolite	Metabolism; Others
	Copper tripeptide (GHK-Cu) 是天然存在的三肽，首先从人血浆中分离，但也能够在唾液和尿液中发现。它能够提高成纤维细胞中胶原蛋白，弹性蛋白，蛋白多糖和糖胺聚糖中信使 RNA 的产生。在伤口愈合期间，它能够通过蛋白水解从现有的细胞外蛋白质中除去，并且用作炎性和内皮细胞的化学引诱物。它是皮肤再生中多种细胞途径的天然调节剂。
T9138	Indirubin-3′-oxime Indirubin-3'-monoxime	GSK-3; CDK; JNK	Cell Cycle/Checkpoint; MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	Indirubin-3′-oxime 是一种有效的细胞周期蛋白依赖性蛋白激酶抑制剂，是 indirubin 的合成衍生物。它可通过激活软骨细胞中的 Wnt/β-catenin 信号来促进身高增长，可能在阿尔茨海默病的神经元凋亡中发挥作用。
T5129	SRI-011381 hydrochloride SRI-011381 hydrochloride [1629138-41-5(free base)]	TGF-beta/Smad	Stem Cells
	SRI-011381 hydrochloride 是口服具有活力的TGF-β信号通路的激活剂，具有神经保护活性。
TD0098	Direct Red 80 Sirius Red,天狼猩红,Sirius Red F 3BA,C.I. direct red 80	Others	Others
	Direct Red 80 (Sirius Red) 是一种聚偶氮染料，在降解时不会释放联苯胺，比许多传统的直接染料更安全，主要用于胶原蛋白和淀粉样蛋白的染色方法。
T1606	Fasudil HA-1077,AT877,法舒地尔	ROCK; Serine/threonin kinase; Calcium Channel; PKA; PKC; Autophagy	Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors
	Fasudil (HA-1077) 是一种非特异性 RhoA/ROCK 抑制剂，也是 Ca2+通道拮抗剂和血管扩张剂。它对蛋白激酶有抑制作用，ROCK1 的 Ki 值为 0.33 μM，ROCK2 和 PKA、PKC、PKG 的 IC50值分别 0.158 μM 和 4.58 μM、12.30 μM、1.650 μM。
T3060	Fasudil hydrochloride Fasudil (HA-1077) HCl,盐酸法舒地尔,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877	ROCK; Serine/threonin kinase; Calcium Channel; HIV Protease; PKA; PKC; Autophagy	Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	Fasudil hydrochloride (HA-1077) 是一种非特异性RhoA/ROCK 抑制剂，也抑制蛋白激酶，对 ROCK1、PKA、PKC 和 MLCK 的 Ki 值分别为 0.33 μM、1.0 μM、9.3 μM 和 55 μM。
T23906	Collagenase inhibitor CI-2 SC 40827
	SC 40827 is a Collagenase inhibitor CI-2.
T3757	NQ301	Thrombin; Platelet aggregation	Others; Proteases/Proteasome
	NQ301 是一种抗血栓剂，能够抑制胶原蛋白激发的兔血小板聚集，IC50=10 mg/mL。
T15124	Diethyl-pythiDC	Others; Hydroxylase	Metabolism; Others
	Diethyl-pythiDC 是一种胶原蛋白脯氨酰 4-羟化酶抑制剂。
T8988	PythiDC	Others	Others
	PythiDC 是一种选择性胶原脯氨酰 4-羟化酶抑制剂，既不会引起一般毒性，也不会破坏铁稳态。
T74030	MAHMA NONOate	Endogenous Metabolite; NO Synthase	Immunology/Inflammation; Metabolism
	MAHMA NONOate 是一种依赖于 pH 调节的 NO 供体。MAHMA NONOate 对胶原蛋白或 ADP 诱导的血小板聚集有抑制作用。
TP2492	Hexapeptide-9 Acetate Hexapeptide-9 Acetate(1228371-11-6 Free base)	Others	Others
	Hexapeptide-9 Acetate 是一种胶原蛋白肽，通过与皮肤细胞自然相互作用来帮助强化结构组织，从而促进再生过程。
T67961	Safironil	Others	Others
	safironil 是一种新型抗纤维化化合物，是胶原蛋白合成的竞争性抑制剂。safironil 在体外实验中对由胶原蛋白I mRNA 或平滑肌α-actin 水平监测的成纤维细胞的激活，以及由I 型和III 型胶原蛋白和层粘连蛋白生产判断的纤维生成有抑制作用。safironil 在不改变总羟脯氨酸的情况下对肝脏肉芽肿的大小没有影响，但通过增加III 型和减少I 型胶原的沉积改变了纤维化的模式。
TP2365L	Acetyl tetrapeptide-9 Acetate Acetyl tetrapeptide-9 Acetate(928006-50-2 Free base)	Others	Others
	Acetyl tetrapeptide-9 Acetate 在刺激基底膜多糖（lumican）和胶原蛋白 I 的合成中发挥作用。
T5589	H-Gly-Pro-OH Glycyl proline,甘油-L-脯氨酸,Glycyl-L-proline	Endogenous Metabolite	Metabolism
	H-Gly-Pro-OH (Glycyl proline) 是胶原蛋白代谢的最终产物，能够被脯氨肽酶进一步裂解。
T15681	L-161982	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	L-161982 是选择性的 EP4 受体拮抗剂。L-161982 可以抑制 PGE2 诱导的 HCA-7 细胞 ERK 磷酸化和细胞增殖。L-161982 可以缓解胶原诱导的小鼠关节炎。
T2386	Pirfenidone S-7701,AMR-69,S-7701,AMR69,吡非尼酮	CCR; TGF-beta/Smad	Immunology/Inflammation; Microbiology/Virology; Stem Cells
	Pirfenidone (AMR69) 是一种抗纤维化剂，可减弱纤维细胞中CCL2和CCL12的产生。它可抑制细胞生长，并能降低人胶质瘤细胞系中的TGF-β2蛋白水平，具有抗炎活性。
T21653	1,4-DPCA	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	1,4-DPCA 是一种脯氨酰羟化酶抑制剂，对人源包皮成纤维细胞中胶原羟基化的 IC50 为 2.4 μM，对因子抑制 HIF (FIH) 的 IC50 为 60 μM。
T38369	CAY10678	Prostaglandin Receptor; PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; GPCR/G Protein; Immunology/Inflammation
	CAY10678 是一种 mPGES-1抑制剂，抑制 PD-1。CAY10678 可减少胶原沉积和T细胞耗竭，可用于研究黑色素瘤。
T29071	UR13870 Org 48762-0,POLB 001,UR-13870,UR 13870	p38 MAPK	MAPK
	UR-13870 (Org 48762-0) 是一种具有口服活性和选择性的 p38 丝裂原活化蛋白激酶（MAPK）抑制剂，可防止小鼠胶原诱导的关节炎中的骨损伤。
T14842	BW 245C BW245C	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	BW 245C 是一种选择性的前列腺素类DP受体(DP1)激动剂，是一种前列腺素类似物，对胶原蛋白的聚集反应有抑制作用，可用于研究中风等疾病。
TP2363L	Acetyl tetrapeptide-2 Acetate Acetyl tetrapeptide-2 Acetate(757942-88-4 Free base)	Others	Others
	Acetyl tetrapeptide-2 Acetate 常用作皮肤调理剂。 Acetyl tetrapeptide-2 Acetate 是通过补偿皮肤中的激素损失来完成的，尤其是胶原蛋白，为皮肤提供了一些丰满的效果。
TP2490	Palmitoyl Hexapeptide-12 Acetate Palmitoyl Hexapeptide-12 Acetate(171263-26-6 Free base)	Others	Others
	Palmitoyl Hexapeptide-12 Acetate (Palmitoyl Hexapeptide-12 Acetate (171263-26-6 Free base)) 可以促进胶原蛋白、弹性蛋白和透明质酸的增殖。可用于改善皮肤含水量，增加真皮层厚度，减少细纹。
T8855	Polydeoxyribonucleotide(Sodium salt) Polydeoxyribonucleotide from salmon	Others	Others
	Polydeoxyribonucleotide(Sodium salt) 可改善大鼠跟腱损伤模型中各种生长因子的分泌，促进胶原蛋白合成，恢复跟腱的拉伸强度。
T26917	BTT-3033 BTT3033,BTT 3033	Apoptosis; Integrin	Apoptosis; Cytoskeletal Signaling
	BTT-3033 是一种具有口服活性和高效性的 α2β1 (EC50: 130 nM) 抑制剂，EC50 值为 130 nM。 BTT-3033 对α2I domain 有亲和力，对血小板与 collagen Ⅰ 结合和细胞增殖有抑制作用。BTT-3033 诱导细胞凋亡，可用于研究前列腺癌、炎症和心血管疾病。
TP1156	H-Gly-Gly-Pro-OH Glycyl-glycyl-L-proline	Others	Others
	H-Gly-Gly-Pro-OH (Glycyl-glycyl-L-proline) 是由甘氨酸和脯氨酸组成的二肽，是胶原代谢的终产物，被脯氨酸酶进一步裂解。
T19389	L-Ascorbic acid 2-phosphate magnesium 2-Phospho-L-ascorbic acid magnesium,维生素C磷酸酯镁,维生素 C 磷酸酯镁	Phosphatase; Phosphorylase	Metabolism
	L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) 是长效的维生素 C 衍生物，能够以刺激胶原蛋白的表达和形成。它提高成骨细胞分化过程中 hASC 中的碱性磷酸酶特性和 runx2A 的表达。它能够以作为培养基补充人脂肪干细胞的成骨分化。
T5286	Glycylglycine Glycyl-glycine,Glycine dipeptide,Diglycocoll,Diglycine,Gly-gly,双甘肽,N-Glycylglycine	Others; Endogenous Metabolite	Metabolism; Others
	Glycylglycine (Diglycine) 是一种简单的多肽，能够作为谷氨酰胺 (gamma-glutamyl) 的受体。
TP2308	TB500 acetate(885340-08-9 free base) Frag17-23 Acetate,TB500 Acetate	Others	Others
	TB500 acetate(885340-08-9 free base) (Frag17-23 Acetate) 是胸腺素 β4 活性区域的合成版本。它促进内皮细胞分化、真皮组织中的血管生成、角质形成细胞迁移、胶原沉积和减少炎症。
T77442	Glenzocimab ACT017	Others	Others
	Glenzocimab (ACT017) 是人源化抗 GPVI 单克隆抗体的 Fab 片段。Glenzocimab 在缺血性卒中模型对胶原诱导的血小板聚集显示出抑制作用。Glenzocimab 具有研究急性缺血性脑卒中和脑血栓。
T8785	HALOFUGINONE LACTATE	DNA/RNA Synthesis; TGF-beta/Smad	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Stem Cells
	HALOFUGINONE LACTATE 是 febrifugine 的卤化衍生物，它是一种天然的含有喹唑啉酮的化合物，存在于中草药 D. febrifuga 中。Halofuginone 以 ATP 依赖性方式抑制脯氨酰-tRNA 合成酶，Ki 为 18.3 nM。 Halofuginone 是 I 型胶原合成的特异性抑制剂，通过抑制 TGF-β 活性来减轻骨关节炎 (OA)
T24816	SP-100030 SP100030,SP 100030	NF-κB	NF-κB
	SP-100030 是一种有效的 NF-κB 和激活蛋白-1 (AP-1) 双抑制剂 (IC50 分别为 50 和 50 nM)。SP-10003 抑制 Jurkat 和其他T 细胞系产生的 IL-2、IL-8 和 TNF-α 的产生。SP-100030 降低小鼠胶原性关节炎 (CIA)。

化合物

Collagen proline hydroxylase inhibitor-1

Cat.No: T10861

Target: Others

Bovine Type II Collagen

Cat.No: T80025

Synonym: Collagen, Type II, Immunization Grade

Collagen proline hydroxylase inhibitor

Cat.No: T10862

Target: Others

type II collagen fragment

Cat.No: TP2301

Target: Others

Alpha 1(I) Collagen (614-639), human

Cat.No: TP1643

Collagen type IV alpha1 (531-543)

Cat.No: TP2452

Synonym: Hep III peptide,Gefyfdlrlkgdk

Collagen-IN-1

Cat.No: T60303

Cat.No: T7692

Target: HIF

Cat.No: T10860

Target: HSP

Cat.No: T16886

Synonym: Adenosyl-Ornithine,西奈芬净,A-9145,Antibiotic 32232RP

Target: Others, Histone Methyltransferase, Antibiotic, Antifungal

Cat.No: T2057

Target: Dehydrogenase

Cat.No: TP1328

Target: Others

Cat.No: T21616

Synonym: L 006235

Target: Cysteine Protease

Cat.No: T11699

Target: CCR

Cat.No: T4283

Target: TGF-beta/Smad

Cat.No: T6576

Synonym: Malotilatum,NKK 105,马洛替酯,Kantec

Target: Lipoxygenase

Cat.No: T9195

Synonym: ARQ252

Target: Apoptosis, JAK

Cat.No: T5329

Target: Angiotensin-converting Enzyme (ACE)

Copper tripeptide

Cat.No: TP1158

Synonym: [N2-(N-甘氨酰-L-组氨酰)-L-赖氨酸]铜,GHK-Cu

Target: Others, Endogenous Metabolite

Indirubin-3′-oxime

Cat.No: T9138

Synonym: Indirubin-3'-monoxime

Target: GSK-3, CDK, JNK

SRI-011381 hydrochloride

Cat.No: T5129

Synonym: SRI-011381 hydrochloride [1629138-41-5(free base)]

Target: TGF-beta/Smad

Cat.No: TD0098

Synonym: Sirius Red,天狼猩红,Sirius Red F 3BA,C.I. direct red 80

Target: Others

Cat.No: T1606

Synonym: HA-1077,AT877,法舒地尔

Target: ROCK, Serine/threonin kinase, Calcium Channel, PKA, PKC, Autophagy

Fasudil hydrochloride

Cat.No: T3060

Synonym: Fasudil (HA-1077) HCl,盐酸法舒地尔,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877

Target: ROCK, Serine/threonin kinase, Calcium Channel, HIV Protease, PKA, PKC, Autophagy

Collagenase inhibitor CI-2

Cat.No: T23906

Synonym: SC 40827

Cat.No: T3757

Target: Thrombin, Platelet aggregation

Diethyl-pythiDC

Cat.No: T15124

Target: Others, Hydroxylase

Cat.No: T8988

Target: Others

Cat.No: T74030

Target: Endogenous Metabolite, NO Synthase

Hexapeptide-9 Acetate

Cat.No: TP2492

Synonym: Hexapeptide-9 Acetate(1228371-11-6 Free base)

Target: Others

Cat.No: T67961

Target: Others

Acetyl tetrapeptide-9 Acetate

Cat.No: TP2365L

Synonym: Acetyl tetrapeptide-9 Acetate(928006-50-2 Free base)

Target: Others

Cat.No: T5589

Synonym: Glycyl proline,甘油-L-脯氨酸,Glycyl-L-proline

Target: Endogenous Metabolite

Cat.No: T15681

Target: Prostaglandin Receptor

Cat.No: T2386

Synonym: S-7701,AMR-69,S-7701,AMR69,吡非尼酮

Target: CCR, TGF-beta/Smad

Cat.No: T21653

Target: HIF/HIF Prolyl-Hydroxylase

Cat.No: T38369

Target: Prostaglandin Receptor, PD-1/PD-L1

Cat.No: T29071

Synonym: Org 48762-0,POLB 001,UR-13870,UR 13870

Target: p38 MAPK

Cat.No: T14842

Synonym: BW245C

Target: Prostaglandin Receptor

Acetyl tetrapeptide-2 Acetate

Cat.No: TP2363L

Synonym: Acetyl tetrapeptide-2 Acetate(757942-88-4 Free base)

Target: Others

Palmitoyl Hexapeptide-12 Acetate

Cat.No: TP2490

Synonym: Palmitoyl Hexapeptide-12 Acetate(171263-26-6 Free base)

Target: Others

Polydeoxyribonucleotide(Sodium salt)

Cat.No: T8855

Synonym: Polydeoxyribonucleotide from salmon

Target: Others

Cat.No: T26917

Synonym: BTT3033,BTT 3033

Target: Apoptosis, Integrin

H-Gly-Gly-Pro-OH

Cat.No: TP1156

Synonym: Glycyl-glycyl-L-proline

Target: Others

L-Ascorbic acid 2-phosphate magnesium

Cat.No: T19389

Synonym: 2-Phospho-L-ascorbic acid magnesium,维生素C磷酸酯镁,维生素 C 磷酸酯镁

Target: Phosphatase, Phosphorylase

Cat.No: T5286

Synonym: Glycyl-glycine,Glycine dipeptide,Diglycocoll,Diglycine,Gly-gly,双甘肽,N-Glycylglycine

Target: Others, Endogenous Metabolite

TB500 acetate(885340-08-9 free base)

Cat.No: TP2308

Synonym: Frag17-23 Acetate,TB500 Acetate

Target: Others

Cat.No: T77442

Synonym: ACT017

Target: Others

HALOFUGINONE LACTATE

Cat.No: T8785

Target: DNA/RNA Synthesis, TGF-beta/Smad

Cat.No: T24816

Synonym: SP100030,SP 100030

Target: NF-κB

Cat. No.	Product Name	Target	Signaling Pathways
T37512	cis-4-Hydroxy-L-proline	Endogenous Metabolite	Metabolism
	cis-4-Hydroxy-L-proline 是脯氨酸的一种类似物，抑制胶原蛋白的产生。它通过阻止三层螺旋胶原在细胞层上的沉积从而抑制成纤维细胞的生长。它还可抑制原发性N-亚硝基甲基脲诱导的大鼠乳腺肿瘤的生长。
T6856	Halofuginone 卤夫酮,常山酮,Tempostatin,empostatin,RU-19110	Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Stem Cells
	Halofuginone (RU-19110) 是Febrifugine 的衍生物，是一种竞争性脯氨酰-tRNA 合成酶抑制剂。它也是肺血管扩张剂，可激活Kv 通道并阻断电压门控、受体操作和存储操作的钙离子通道。它具有抗炎、抗癌、抗疟疾和抗纤维化作用。
T3524	Halofuginone hydrobromide 卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐	Others; Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Others; Stem Cells
	Halofuginone hydrobromid 是Febrifugine 的衍生物，是竞争性脯氨酰-tRNA 合成酶抑制剂。它是 I 型胶原合成的特异性抑制剂，并通过抑制TGF-β活性可减轻骨关节炎。它具有抗疟疾、抗炎、抗癌、抗纤维化作用。
T5684	Ethyl 3,4-dihydroxybenzoate	Apoptosis; Others; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; NO Synthase; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; Others
	Ethyl 3,4-dihydroxybenzoate 是从花生种子的种皮中发现的脯氨酰羟化酶抑制剂，是一种抗氧化剂。它是胶原蛋白合成抑制剂，具有骨骼保护作用。它通过激活 NO 合酶并产生线粒体 ROS 来保护心肌，可诱导 ESCC 细胞自噬和凋亡。
T0928	L-Ascorbic acid 维生素C,Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,抗坏血酸,L-Ascorbate	Apoptosis; Calcium Channel; Reactive Oxygen Species; Endogenous Metabolite	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
	L-Ascorbic acid (Vitamin C) 属于天然产物，是一种强效的还原剂和抗氧化剂。L-Ascorbic acid 具有抗细菌感染、解毒反应和胶原蛋白形成的作用。L-Ascorbic acid 被用于治疗坏血病。
T4454	Traumatic Acid Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,愈伤酸,Trans-2-Dodecenedioic Acid	Antioxidant	oxidation-reduction
	Traumatic Acid (Dodec-2-Enedioic Acid) 是一种单不饱和二元羧酸，从菜豆中分离得到。它可减少膜磷脂的过氧化，并表现出抗氧化和对胶原生物合成的刺激作用。它可用于许多与胶原蛋白生物合成障碍和氧化应激有关的皮肤疾病的研究。
T64812	Collagenase Type I Collagenase I,Collagenase Type I (From microorganisms)	Others	Others
	Collagenase Type I 是一种蛋白水解酶，能分解胶原蛋白中的肽键（胶原蛋白是结缔组织的主要结构蛋白）。Collagenase 已被探索作为一种潜在的治疗选择来分解突出的椎间盘物质，从而减少对附近神经的压迫。Collagenase 可能有助于过度疤痕组织的分解和重组，潜在地改善组织功能和外观。Collagenase 具有治疗椎间盘突出、瘢痕疙瘩、脂肪团、脂肪瘤以及佩罗尼氏病和手掌纤维瘤病等方面的潜力。
T3S1944	Darutoside Darutin,豯莶苷	Others	Others
	Darutoside (Darutin) 是一种二萜化合物，提取自Siegesbeckia 中。
TN6975	Cirsiumaldehyde 5,5’-oxydimethylenebis(2-furfural)	Platelet aggregation	Others
	Cirsiumaldehyde 是一种从Lobelia chinensis、Cornus officinalis 成熟果实和 Hippophae rhamnoides 果实中分分离出的化合物。Cirsiumaldehyde 在胶原蛋白存在下对 U46619 诱导（1~5 uM）的大鼠血小板聚集的抑制浓度为 0.8~1.0 ug/mL。
TN2315	Xanthopurpurin 茜草红素,1,3-二羥蒽醌,异茜草素	Platelet aggregation; Antifection	Microbiology/Virology; Others
	Xanthopurpurin 是分离自Rubia akane 根茎的蒽醌苷。Xanthopurpurin 主要对胶原诱导的血小板聚集有较强的抑制作用。
T5S0896	Loureirin A 龙血素 A,龙血素A	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Loureirin A 是一种黄酮类物质，从龙血树中分离得到，能够降低Akt 的磷酸化，具有抗血小板聚集作用。
T2O2798	D-(+)-Trehalose Ergot Sugar,D-Trehalose,Mycose,D-(+)-Trehalose Anhydrous,D-海藻糖,Trehalose	Others; Endogenous Metabolite	Metabolism; Others
	D-(+)-Trehalose (Mycose) 来源于自Saccharomyces cerevisiae，常用作食品成分和药物赋形剂。
T5703	β,β-Dimethylacrylalkannin	Others	Others
	β,β-Dimethylacrylalkannin 是一种萘醌类化合物，分离自紫草属植物中，可以提高皮肤细胞中胶原蛋白和内披蛋白的含量。
T3781	Jujuboside B 酸枣仁皂苷 B,酸枣仁皂苷B	Others	Others
	Jujuboside B 是一种提取自Zizyphus jujuba 中的活性成分，对血小板聚集具有抑制作用。
TN3831	(-)-Denudatin B Denudatin B	ATPase; Potassium Channel; Calcium Channel; PAFR	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism
	(-)-Denudatin B (Denudatin B) 源自 Magnolia fargesii。 (-)-Denudatin B 通过抑制胶原蛋白和凝血酶诱导的磷酸肌醇分解，在高浓度下具有非特异性抗血小板作用。
TN1873	Lirinidine	Others	Others
	Lirinidine 是一种分离自L. tulipifera 叶片生物碱，具有抗氧化 (antioxidant) 和抗癌作用。它在体外表现出中等的铁还原能力和较小的自由基清除能力，可用于研究化妆品。
TN6710	Methyl acetylsalicylate ACETYLSALICYLIC ACID METHYL ESTER,乙酰水杨酸甲酯	Others	Others
	Methyl acetylsalicylate (ACETYLSALICYLIC ACID METHYL ESTER) 是一种从豌豆中分离出来的天然产物。抑制胶原蛋白诱导的人富含血小板的血浆聚集。
TN1507	Clematichinenoside AR	TNF; Autophagy	Apoptosis; Autophagy
	Clematichinenoside AR 是从中药威灵仙中提取的一种天然产物，具有抗炎和免疫抑制特性，对 PI3K/Akt 信号通路和与胶原诱导的关节炎相关的 TNF-α± 具有抗关节炎作用。
T4S0498	Glaucocalyxin A 蓝萼甲素,Wangzaozin B,Leukamenin F	Apoptosis; Akt; Caspase; PI3K	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜，具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位，诱导骨肉瘤凋亡。
T4928	L-Kynurenine L-犬尿氨酸,(S)-Kynurenine	AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物，是芳香烃受体激动剂，可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。
T2769	3-Aminopropionitrile fumarate (2:1) Di-β-aminopropionitrile fumarate,3-Aminopropionitrile fumarate,3-氨基丙腈,β-Aminopropionitrile fumarate,3-Aminopropionitrile fumarate 2:1,Beta-Aminopropionitrile fumarate,β-Ammoniumpropionitrile hemifumarate	Others	Others
	3-Aminopropionitrile fumarate (2:1) (β-Aminopropionitrile fumarate) 是一种能抑制胶原蛋白(collagen)交联的山黧豆素。
TN1254	3'-Methoxydaidzein 3'-甲氧基大豆苷元	Sodium Channel	Membrane transporter/Ion channel
	3'-Methoxydaidzein 是一种异黄酮和 Sodium Channel 双重抑制剂。3'-Methoxydaidzein 对NaV1.7、NaV1.8 和 NaV1.3有抑制作用，IC50 分别为 181 nM、397 nM 和 505 nM。 3'-Methoxydaidzein 对胶原诱导的血小板聚集具有特异性，IC50值分别为12.3和61.5µM。。3'-Methoxydaidzein 通过抑制电压门控钠通道发挥镇痛作用。 3'-Methoxydaidzein 具有抗氧化活性和抗血小板聚集活性。
T2O2721	L-Cysteine Thioserine,L-半胱氨酸,cysteine,半胱氨酸,L-(+)-Cysteine	Endogenous Metabolite	Metabolism
	L-Cysteine (L-(+)-Cysteine) 是人体非必需的含硫氨基酸。L-Cysteine 对蛋白质合成、解毒和多种代谢功能很重要。L-Cysteine 存在于指甲、皮肤和头发的主要蛋白质-角蛋白中，对胶原蛋白的生成、皮肤弹性和质地都很重要。L-Cysteine 是抗氧化剂谷胱甘肽的一种成分，在辅酶A、肝素和生物素等基本生化物质的代谢中起着重要作用，也是氨基酸牛磺酸的制造所必需的。
T4430	Isosaponarin	Others	Others
	Isosaponarin increases collagen synthesis in human fibroblasts, causes by up-regulated TbetaR-II and P4H production.
TN6495	3,4-O-dimethylcedrusin
	3′,4-O-Dimethylcedrusin can improve wound healing in vivo by stimulating the formation of fibroblasts and collagen.
TN3740	Cyclocommunol	PAFR	GPCR/G Protein
	Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong inhibition of arachidonic acid (AA)- and collagen-induced platelet aggregation.
T19394	L-hydroxylysine dihydrochloride (2S,5R)-5-Hydroxylysine dihydrochloride	Others	Others
	L-hydroxylysine dihydrochloride , is formed by posttranslational hydroxylation of some lysine residues. It is an amino acid, is exclusive to collagen protein.
T72798	Ganodermaones B
	Ganodermaones B 是一种肾纤维化抑制剂，抑制 TGF-β1诱导的 collagen I 和 fibronectin 的表达。
TN5661	1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one
	1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one shows strong inhibition of collagen-induced, arachidonic acid-induced, and adenosine diphosphate-induced platelet aggregation of human whole blood.
T31382	Deoxypyridinoline Lysylpyridinoline
	Deoxypyridinoline is one of two pyridinium cross-links that provide structural stiffness to type I collagen found in bones. It is excreted unmetabolized in urine and is a specific marker of bone resorption and osteoclastic activity.
TN1309	6-Hydroxykaempferol-3,6,7-triglucoside	Others	Others
	6-Hydroxykaempferol 3,6,7-tri-O-glucoside and 6-hydroxykaempferol 3,6-di-O-glucoside can inhibit platelet aggregation induced by collagen, they also show weak inhibitory effects on the adenosine 5'-diphosphate (ADP)- induced platelet aggregation.
TL0017	Aristolactam AIIIa	MAPK; CDK	Cell Cycle/Checkpoint; MAPK
	Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of platelet aggregation induced by collagen or arachidonic acid.
TN5447	Apigenin 7-O-methylglucuronide 芹菜素-7-O-β-D-葡萄糖醛酸甲酯,Apigenin-7-O-β-D-glucuronide methyl ester
	Apigenin 7-O-methylglucuronide did not affect GAG level or secretion, may potentially be used in osteogenesis imperfecta (OI) type I pharmacotherapy in patients with normal GAG content. Apigenin 7-O-methylglucuronide which normalized collagen synthesis in
TN1310	6-Hydroxykaempferol 3,6-diglucoside	Others	Others
	6-Hydroxykaempferol 3,6-di-O-glucoside and 6-hydroxykaempferol 3,6,7-tri-O-glucoside can inhibit platelet aggregation induced by collagen, they also show weak inhibitory effects on the adenosine 5'-diphosphate (ADP)- induced platelet aggregation.
T79983	Flaccidoside II	Apoptosis	Apoptosis
	Flaccidoside II 是一种源自Anemone flaccida根茎的三萜皂苷，能抑制恶性周围神经鞘瘤(MPNST)细胞系增殖并诱导细胞凋亡(apoptosis)。此外，Flaccidoside II 亦能改善由胶原蛋白引发的小鼠关节炎症状。
T2O2683	L-Proline L-(-)-Proline,proline,脯氨酸,L-脯氨酸	Endogenous Metabolite	Metabolism
	L-Proline (proline) 是人体非必需氨基酸。它是胶原蛋白的重要组成部分，对关节和肌腱的正常运作很重要。它还有助于维持和加强心脏肌肉。
TN4490	Manassantin B	ERK; BCL; p38 MAPK; TNF; NF-κB; JNK; STAT; Antifection	Apoptosis; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells
	Manassantin B is a potent inhibitor of NF-ÎºB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-ÎºB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in pa...
TN4664	Norarmepavine	Others	Others
	N-norarmepavine shows significant cytotoxic activities against HL-60 carcinoma cell line with inhibitory ratios of 51.43% at concentration of 1 x 10(-5) M. Norarmepavine shows inhibition against Trypanosoma cruzi. D-(+)- N-norarmepavine exhibits significa
T36845	Isogarcinol
	Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental auto...
T37055	Cytostatin
	Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 μg/ml). Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.
T38330	Collinin
	Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a...
T35624	Ajoene
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

cis-4-Hydroxy-L-proline

Cat.No: T37512

Target: Endogenous Metabolite

Cat.No: T6856

Synonym: 卤夫酮,常山酮,Tempostatin,empostatin,RU-19110

Target: Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad

Halofuginone hydrobromide

Cat.No: T3524

Synonym: 卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐

Target: Others, Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad

Ethyl 3,4-dihydroxybenzoate

Cat.No: T5684

Target: Apoptosis, Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, NO Synthase, Autophagy

L-Ascorbic acid

Cat.No: T0928

Synonym: 维生素C,Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,抗坏血酸,L-Ascorbate

Target: Apoptosis, Calcium Channel, Reactive Oxygen Species, Endogenous Metabolite

Cat.No: T4454

Synonym: Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,愈伤酸,Trans-2-Dodecenedioic Acid

Target: Antioxidant

Collagenase Type I

Cat.No: T64812

Synonym: Collagenase I,Collagenase Type I (From microorganisms)

Target: Others

Cat.No: T3S1944

Synonym: Darutin,豯莶苷

Target: Others

Cirsiumaldehyde

Cat.No: TN6975

Synonym: 5,5’-oxydimethylenebis(2-furfural)

Target: Platelet aggregation

Cat.No: TN2315

Synonym: 茜草红素,1,3-二羥蒽醌,异茜草素

Target: Platelet aggregation, Antifection

Cat.No: T5S0896

Synonym: 龙血素 A,龙血素A

Target: Akt, PI3K

D-(+)-Trehalose

Cat.No: T2O2798

Synonym: Ergot Sugar,D-Trehalose,Mycose,D-(+)-Trehalose Anhydrous,D-海藻糖,Trehalose

Target: Others, Endogenous Metabolite

β,β-Dimethylacrylalkannin

Cat.No: T5703

Target: Others

Cat.No: T3781

Synonym: 酸枣仁皂苷 B,酸枣仁皂苷B

Target: Others

(-)-Denudatin B

Cat.No: TN3831

Synonym: Denudatin B

Target: ATPase, Potassium Channel, Calcium Channel, PAFR

Cat.No: TN1873

Target: Others

Methyl acetylsalicylate

Cat.No: TN6710

Synonym: ACETYLSALICYLIC ACID METHYL ESTER,乙酰水杨酸甲酯

Target: Others

Clematichinenoside AR

Cat.No: TN1507

Target: TNF, Autophagy

Glaucocalyxin A

Cat.No: T4S0498

Synonym: 蓝萼甲素,Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Cat.No: T4928

Synonym: L-犬尿氨酸,(S)-Kynurenine

Target: AhR, Aryl Hydrocarbon Receptor, Endogenous Metabolite

3-Aminopropionitrile fumarate (2:1)

Cat.No: T2769

Synonym: Di-β-aminopropionitrile fumarate,3-Aminopropionitrile fumarate,3-氨基丙腈,β-Aminopropionitrile fumarate,3-Aminopropionitrile fumarate 2:1,Beta-Aminopropionitrile fumarate,β-Ammoniumpropionitrile hemifumarate

Target: Others

3'-Methoxydaidzein

Cat.No: TN1254

Synonym: 3'-甲氧基大豆苷元

Target: Sodium Channel

Cat.No: T2O2721

Synonym: Thioserine,L-半胱氨酸,cysteine,半胱氨酸,L-(+)-Cysteine

Target: Endogenous Metabolite

Cat.No: T4430

Target: Others

3,4-O-dimethylcedrusin

Cat.No: TN6495

Cat.No: TN3740

Target: PAFR

L-hydroxylysine dihydrochloride

Cat.No: T19394

Synonym: (2S,5R)-5-Hydroxylysine dihydrochloride

Target: Others

Ganodermaones B

Cat.No: T72798

1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one

Cat.No: TN5661

Deoxypyridinoline

Cat.No: T31382

Synonym: Lysylpyridinoline

6-Hydroxykaempferol-3,6,7-triglucoside

Cat.No: TN1309

Target: Others

Aristolactam AIIIa

Cat.No: TL0017

Target: MAPK, CDK

Apigenin 7-O-methylglucuronide

Cat.No: TN5447

Synonym: 芹菜素-7-O-β-D-葡萄糖醛酸甲酯,Apigenin-7-O-β-D-glucuronide methyl ester

6-Hydroxykaempferol 3,6-diglucoside

Cat.No: TN1310

Target: Others

Flaccidoside II

Cat.No: T79983

Target: Apoptosis

Cat.No: T2O2683

Synonym: L-(-)-Proline,proline,脯氨酸,L-脯氨酸

Target: Endogenous Metabolite

Cat.No: TN4490

Target: ERK, BCL, p38 MAPK, TNF, NF-κB, JNK, STAT, Antifection

Cat.No: TN4664

Target: Others

Cat.No: T36845

Cat.No: T37055

Cat.No: T38330

Cat.No: T35624

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