SAP15 (Synthetic anti-inflammatory peptide 15) acetate is a synthetic anti-inflammatory peptide composed of 15 amino acids, designed from human β-defensin 3. It can penetrate cells and downregulate intracellular inflammation by inhibiting the phosphorylation of HDAC5, thereby reducing the phosphorylation of NF-κBp65, which in turn suppresses inflammatory responses. Additionally, SAP15 acetate inhibits the phosphorylation of HDAC5 and NF-κBp65 in LPS-induced macrophages. Treatment with SAP15 acetate enhances the expression of aggrecan and type II collagen while reducing osteocalcin expression in LPS-induced chondrocytes. This compound is useful for research related to the modulation of inflammation and anti-inflammatory properties in biomaterials.

Synthetic anti-inflammatory peptide 15 acetate