Name: Osteostatin
Brand: TargetMol
SKU: T81592
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 mg

待询

50 mg

待询

生物活性

产品描述	Osteostatin, derived from parathyroid hormone-related protein (PTHrP) 107-111, has demonstrated properties conducive to bone repair in animal models presenting with bone defects and exhibits efficacy in mitigating bone erosion associated with inflammatory arthritis. Additionally, it possesses the capacity to inhibit both collagen-induced arthritis and direct osteoclastic bone resorption, marking its potential utility in inflammation and immunology research [1] [2] [3] [4].
体外活性	Osteostatin (100、250、500 nM，7-9天) 浓度依赖性地减少了破骨细胞的分化[2]。
体内活性	骨肽（每天皮下注射80或120 μg/kg，治疗从疾病发作后开始，连续13天）能显著减轻关节炎症状并抑制软骨及骨质的降解^[4]。
别名	PTHrP (107–111)

化学信息

分子量	619.67
分子式	C₂₇H₄₁N₉O₈
CAS No.	138949-73-2
Smiles	C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@@H](C)O)N)=O)CCCNC(=N)N)=O)CO)=O)C)=O)C(O)=O)C=1C=2C(NC1)=CC=CC2
Sequence	Thr-Arg-Ser-Ala-Trp
Sequence Short	TRSAW

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Osteostatin