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Collagenase Type I

产品编号 T64812 CAS 9001-12-1

别名: Collagenase I, Collagenase Type I (From microorganisms)

Collagenase Type I 是一种蛋白水解酶，能分解胶原蛋白中的肽键（胶原蛋白是结缔组织的主要结构蛋白）。Collagenase 已被探索作为一种潜在的治疗选择来分解突出的椎间盘物质，从而减少对附近神经的压迫。Collagenase 可能有助于过度疤痕组织的分解和重组，潜在地改善组织功能和外观。Collagenase 具有治疗椎间盘突出、瘢痕疙瘩、脂肪团、脂肪瘤以及佩罗尼氏病和手掌纤维瘤病等方面的潜力。

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Collagenase Type I, CAS 9001-12-1

规格	价格/CNY	货期
5 mg	￥ 118	现货
10 mg	￥ 158	现货
25 mg	￥ 247	现货
50 mg	￥ 372	现货
100 mg	￥ 538	现货

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效价: 400 u/mg

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天然产物信息

生物活性

化学信息

存储 & 溶解度

参考文献

结构类型

天然产物 > 其他

产品描述	Collagenase Type I is a proteolytic enzyme that breaks down the peptide bonds in collagen, the main structural protein of connective tissue. Collagenase has been explored as a potential treatment option to break down herniated disc material, thereby reducing pressure on nearby nerves. Collagenase may aid in the breakdown and reorganization of excessive scar tissue, potentially improving tissue function and appearance. Collagenase has the potential to treat disc herniation, keloid, cellulite, lipoma, as well as Peroni's disease and palm fibromatosis.
体外活性	The objective of this study was to determine whether a peptide of type II collagen which can induce collagenase activity can also induce chondrocyte terminal differentiation (hypertrophy) in articulate cartilage. Results show that the induction of collagenase activity by a cryptic peptide sequence of type II collagen is accompanied by chondrocyte hypertrophy and associated with cellular and matrix changes. This induction occurs in the mid and superficial zones of previously healthy articular cartilage. This response of the chondrocyte to a cryptic sequence of denatured type II collagen may play a role in naturally occurring hypertrophy in endochondral ossification and in the development of cartilage pathology in osteoarthritis.[1]
体内活性	Ten New Zealand white rabbits were used as the experimental group and control group. After epithelial debridement, a collagenase type II solution (200 μL of 5 mg/mL) was applied in the experimental group at room temperature (24 °C) for 30 min, and a 200 μL solution without collagenase was applied in the control group. No obvious inflammatory reaction was observed in all eyes after the procedure. The differences in elastic modulus between the experimental and control group were statistically significant at 10% and 15% deformities. Collagenase type II treatment results in mimic KC with increased corneal keratometry and corneal thinning and a lower elastic modulus. An animal model for corneal ectasia can be generated by treatment with collagenase type II.[2]

别名	Collagenase I, Collagenase Type I (From microorganisms)
分子量	N/A
CAS No.	9001-12-1

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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参考文献

1. Tchetina EV,et al. Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: implications for development and arthritis. Matrix Biol. 2007;26(4):247-258. 2. Qiao J, et al. A rabbit model of corneal Ectasia generated by treatment with collagenase type II. BMC Ophthalmol. 2018;18(1):94.

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请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

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体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

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