estrogen receptor α (erα)

Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor.

Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhances the Hsp90 molecular chaperone ATPase activity.

2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate 是 Octinoxate 的氘代物。Octinoxate (Octyl methoxycinnamate) 作为一种甲状腺激素受体 (thyroid hormone receptor) 激动剂，可降低日本 Medaka 鱼体内三碘甲状腺原氨酸 (T3) 和甲状腺素 (T4) 的水平，以及 II 型脱碘酶 (deio2) 相关基因的转录水平。作为一种常见的紫外线 (UV) 过滤剂，Octinoxate 通常被认为在水环境中使用是安全的。它能够抑制 CYP1A1 和 CYP1B1，并以依赖于 PI3K 通路的方式调节人类角质形成细胞中的透明质酸 (HA) 代谢。Octinoxate 在体外和体内均展现出抗雌激素 (anti-estrogenic) 和抗雄激素 (anti-androgenic) 活性。

4-Nonylphenol-d5是4-n-Nonylphenol的氘代标记物，可用于同位素示踪。4-n-Nonylphenol是Nonylphenol ethoxylates(NPEOs)的主要降解物，具有内分泌干扰特性和微弱的雌激素样活性。

Cholesterol-d6 是 Cholesterol 氘代物，可用于研究脂质膜的流动和 Cholesterol在体内的代谢情况。

Zearalenone-13C18is intended for use as an internal standard for the quantification of zearalenone by GC- or LC-MS. Zearalenone is a mycotoxin that has been found inFusariumand has estrogenic activities.1It binds to human estrogen receptor α (ERα) and ERβ (IC50s = 9 and 5.8 nM, respectively).2Zearalenone induces precocious development of mammary tissues in young female pigs and prepucial enlargement in young male pigs.3Zearalenone (1.5-5 mg/kg of diet) induces hyperestrogenism in pigs. It also induces degeneration of meiotic chromatin in oocytes and reduces fertility in pigs when administered at a dose of 200 μg/kg.4Zearalenone has been found as a contaminant in wheat, maize, and barley and livestock feeds.3,4