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Nafoxidine

Name: Nafoxidine
Brand: TargetMol
SKU: T21387L
Price: 160 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 萘福昔定

货号 T21387LCas号 1845-11-0 一键复制产品信息纯度: 99.93%

很棒

Nafoxidine 是一种雌激素拮抗剂，已用于治疗乳腺癌。

Nafoxidine

一键复制产品信息

很棒

纯度: 99.93%

货号 T21387LCas号 1845-11-0

别名 萘福昔定

Nafoxidine 是一种雌激素拮抗剂，已用于治疗乳腺癌。

规格	价格	库存
1 mg	¥ 160	现货
5 mg	¥ 371	现货
10 mg	¥ 535	现货
25 mg	¥ 990	现货
50 mg	¥ 1,550	现货
100 mg	¥ 2,470	现货
200 mg	¥ 3,480	现货
1 mL x 10 mM (in DMSO)	¥ 437	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.93%

颜色: 黄色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

Nafoxidine AI Summary

Nafoxidine exhibits a multifaceted bioactivity profile. It shows uterotrophic activity in rats relative to estradiol with a relative activity of 5.5 and demonstrates a relative binding affinity (RBA) for uterine cytosolic estrogen receptors of immature rats at 9.29%. Additionally, it possesses antiimplantation activity in sperm-positive female rats at a minimum effective dose of 0.1 mg kg^-1. The compound also exhibits antiestrogenic effects, inhibiting estrus in ovariectomized rats treated with 17-beta-estradiol with an inhibition rate of 44.0%, and prevents estradiol binding to estrogen receptors with an IC50 of 40.9 nM. In terms of binding affinity, Nafoxidine shows an RBA of 183.0 for chicken liver, 90.0 for rat liver, and 124.0 for guinea pig uterus, suggesting strong antiestrogenic potential. It also binds to human EMP and sigma receptor type 1 with Ki values of 0.9 nM and 30.0 nM, respectively, and exhibits affinity for ERG2 in Saccharomyces cerevisiae with a Ki of 232.0 nM. Against the recombinant rat androgen receptor, it has an IC50 of 12882.5 nM. Further, Nafoxidine demonstrates antiviral activity in different contexts. Against SARS-CoV-2, it exhibits an IC50 > 100000.0 nM, indicating weak potency, and shows a CC50 of 3850.0 nM in VERO-E6 cells. It also inhibits pseudotyped Marburgvirus and Ebola virus strains in human A549 cells with varied IC50 values, highlighting its selective antiviral potential. This compound's complex bioactivity profile suggests potential applications in estrogen receptor modulation, antiviral therapies, and antiestrogenic treatments..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Nafoxidine is an estrogen antagonist that has been used in the treatment of breast cancer.
别名	萘福昔定

化学信息

分子量	425.56
分子式	C₂₉H₃₁NO₂
CAS No.	1845-11-0
Smiles	O(C)C=1C=C2C(C(=C(CC2)C3=CC=CC=C3)C4=CC=C(OCCN5CCCC5)C=C4)=CC1
密度	1.31g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 65 mg/mL (152.74 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.7 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3498 mL	11.7492 mL	23.4984 mL	117.4922 mL
5 mM	0.4700 mL	2.3498 mL	4.6997 mL	23.4984 mL
10 mM	0.2350 mL	1.1749 mL	2.3498 mL	11.7492 mL
20 mM	0.1175 mL	0.5875 mL	1.1749 mL	5.8746 mL
50 mM	0.0470 mL	0.2350 mL	0.4700 mL	2.3498 mL
100 mM	0.0235 mL	0.1175 mL	0.2350 mL	1.1749 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。