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DS45500853是一种新型的ERRα激动剂且不激活PPARγ,通过直接结合ERRα从而促进对PGC-1α共激活肽的招募,具有治疗代谢紊乱(如2型糖尿病)的潜力。
DS45500853是一种新型的ERRα激动剂且不激活PPARγ,通过直接结合ERRα从而促进对PGC-1α共激活肽的招募,具有治疗代谢紊乱(如2型糖尿病)的潜力。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 1,380 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 2,280 | 5日内发货 |
产品描述 | DS45500853 is a novel ERRα agonist that does not activate PPARγ and promotes the recruitment of PGC-1α coactivating peptide by directly binding to ERRα. It has potential for the treatment of metabolic disorders such as type 2 diabetes. |
体外活性 | DS45500853 (0.002,0.006,0.017,0.051,0.015,0.046,1.4,4.2,12.5 μg/mL,18 h)能够抑制 MG63 细胞中全长 ERRα 的转录活性,其EC50值为5.4 μM。[1] |
别名 | DS 45500853 |
分子量 | 284.355 |
分子式 | C18H20O3 |
CAS No. | 2735803-28-6 |
Smiles | CC(=O)c1ccc(Oc2ccc(O)c(c2)C(C)(C)C)cc1 |
密度 | 1.107 g/cm3 (Predicted) |
存储 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 40 mg/mL (140.67 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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