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VHL Ligand 14 (Compound 11),作为VHL配体,具有IC50为196 nM的结合亲和力,可合成用于降解雌激素受体α (ERα) 的PROTAC分子。

VHL Ligand 14 (Compound 11),作为VHL配体,具有IC50为196 nM的结合亲和力,可合成用于降解雌激素受体α (ERα) 的PROTAC分子。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 10 mg | 待询 | 待询 | |
| 50 mg | 待询 | 待询 |
VHL Ligand 14 相关产品
| 产品描述 | VHL Ligand 14 (Compound 11), a VHL ligand engineered for creating PROTAC estrogen receptor α (ERα) degraders, exhibits a binding affinity with an IC50 of 196 nM [1]. |
| 体外活性 | VHL Ligand 14 (5-10 μM) stabilizes the ER degrader in PROTAC, facilitating the degradation of ER [1]. Using Western Blot Analysis [1] with the MCF-7 cell line at a concentration of 5-10 μM over a 4-hour incubation period, it was found to inhibit the degradation of the ER ligand. |
| 分子量 | 486.63 |
| 分子式 | C25H34N4O4S |
| CAS No. | 2010986-87-3 |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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