首页 工具
登录
购物车
Beta Amyloid

Beta Amyloid

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection.
1 2 3 4 5
Cat. No. Product Name CAS No. Purity Chemical Structure
TP1007 β-Amyloid (1-42), human
大豆肽
107761-42-2 99.52%
β-Amyloid (1-42), human 是一种由 42 个氨基酸组成的肽,在阿尔茨海默病的发病机制中起关键作用。
TN1798 Isorosmanol
异迷迭香酚
93780-80-4 98.85%
Isorosmanol 具有抗氧化、神经保护和神经营养作用,可能用于老年性疾病,如认知功能下降和色素沉着。
T19011 Hoechst 34580
化合物Hoechst 34580
23555-00-2 98.84%
Hoechst 34580 (HOE 34580) 是细胞渗透性荧光染料,可用于 DNA 和核染色。
T14525 Begacestat
化合物 T14525
769169-27-9 98%
Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's diseas...
TN3410 Anatabine
化合物 TN3410
581-49-7 98%
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN1653 Fustin
黄颜木素
20725-03-5 98%
Fustin 是植物漆树 (Rhus verniciflua Stokes) 的植物性黄烷醇成分。 Fustin 对 6-羟基多巴胺诱导的神经元细胞死亡具有保护作用。
TN1919 (+)-Medioresinol
梣皮树脂醇
40957-99-1 98%
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in th...
TN4865 Putraflavone
化合物 TN4865
23624-21-7 98%
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
TN3618 Cedrin
化合物 TN3618
75513-81-4 98%
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative s...
TN4571 Mirabijalone D
化合物 TN4571
485811-84-5 98%
Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.It inhibits Aβ1-42 production by 43.7% in APPSW-N2a cells.
T19013 Hoechst 34580 tetrahydrochloride
化合物 T19013
T19013 98%
Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
T10453 BACE1-IN-5
化合物 T10453
2581114-83-0 98%
BACE1-IN-5 (Compound 15) 是一种 BACE1抑制剂,IC50为 9.1 nM。BACE1-IN-5还可抑制细胞 Aβ,IC50为 0.82 nM。并且,BACE1-IN-5 具有改善 hERG 抑制和 P-gp 外排的药物化学作用。
T19142 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
化合物 T19142
566169-98-0 98%
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).
TN3218 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
化合物 TN3218
100667-52-5 98%
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may...
TN4635 Neoechinulin A
化合物 TN4635
51551-29-2 98%
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the ...
T7003 Leucomethylene blue mesylate
化合物TRx0237 mesylate
1236208-20-0 99.99%
Leucomethylene blue mesylate (TRx0237 mesylate) 是一种 Methylene blue (亚甲基蓝)的还原形式, 亚甲基蓝是一种化学指示剂和生物染色剂。它是一种具有口服活性的二代 tau 蛋白聚集的抑制剂 (Ki=为0.12 μM),可用于阿尔兹海默症的研究。
T4398 LX2343
化合物LX2343
333745-53-2 99.92%
LX2343 是一种非 ATP 竞争性 PI3K 抑制剂,IC50 为 15.99±3.23 μM。它是一种 BACE1 酶抑制剂,IC50 值为 11.43±0.36 μM。它在促进 Aβ 清除中刺激自噬。
T4S0350 Licochalcone B
甘草查尔酮 B
58749-23-8 99.9%
Licochalcone B 是从Glycyrrhiza inflate 根中提取的。它能够抑制淀粉样蛋白 β 自聚集作用 (IC50=2.16 μM) ,分解预先形成的 Aβ42原纤维,并通过螯合金属离子抑制金属诱导的 Aβ42聚集。
T60671 MAO-B-IN-9
化合物MAO-B-IN-9
2416910-88-6 99.88%
MAO-B-IN-9是一种可穿过血脑屏障的单胺氧化酶B MAO-B 抑制剂(IC50:0.18μM),具有有效性、选择性和时间依赖性。MAO-B-IN-9具有神经保护作用,可以防止Aβ1-42诱导的神经元细胞死亡,这可能与Aβ1-42的抗聚集作用有关。
TN1216 2-O-Acetyl-20-hydroxyecdysone
2-O-乙酰基-20-羟基蜕皮激素
19536-25-5 99.88%
2-O-Acetyl-20-hydroxyecdysone 是存在于昆虫和陆生植物中的一种蜕皮激素,2-O-Acetyl-20-hydroxyecdysone 对 amyloid-β42 诱导的细胞毒性有抑制作用,能够通过促进纤维发生减少 Aβ 寡聚物的形成,将 Aβ 寡聚物转变为低毒性纤维。
β-Amyloid (1-42), human
TP1007
β-Amyloid (1-42), human 是一种由 42 个氨基酸组成的肽,在阿尔茨海默病的发病机制中起关键作用。
Isorosmanol
TN1798
Isorosmanol 具有抗氧化、神经保护和神经营养作用,可能用于老年性疾病,如认知功能下降和色素沉着。
Hoechst 34580
T19011
Hoechst 34580 (HOE 34580) 是细胞渗透性荧光染料,可用于 DNA 和核染色。
Begacestat
T14525
Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's diseas...
Anatabine
TN3410
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
Fustin
TN1653
Fustin 是植物漆树 (Rhus verniciflua Stokes) 的植物性黄烷醇成分。 Fustin 对 6-羟基多巴胺诱导的神经元细胞死亡具有保护作用。
(+)-Medioresinol
TN1919
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in th...
Putraflavone
TN4865
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
Cedrin
TN3618
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative s...
Mirabijalone D
TN4571
Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.It inhibits Aβ1-42 production by 43.7% in APPSW-N2a cells.
Hoechst 34580 tetrahydrochloride
T19013
Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
BACE1-IN-5
T10453
BACE1-IN-5 (Compound 15) 是一种 BACE1抑制剂,IC50为 9.1 nM。BACE1-IN-5还可抑制细胞 Aβ,IC50为 0.82 nM。并且,BACE1-IN-5 具有改善 hERG 抑制和 P-gp 外排的药物化学作用。
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
T19142
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
TN3218
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may...
Neoechinulin A
TN4635
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the ...
Leucomethylene blue mesylate
T7003
Leucomethylene blue mesylate (TRx0237 mesylate) 是一种 Methylene blue (亚甲基蓝)的还原形式, 亚甲基蓝是一种化学指示剂和生物染色剂。它是一种具有口服活性的二代 tau 蛋白聚集的抑制剂 (Ki=为0.12 μM),可用于阿尔兹海默症的研究。
LX2343
T4398
LX2343 是一种非 ATP 竞争性 PI3K 抑制剂,IC50 为 15.99±3.23 μM。它是一种 BACE1 酶抑制剂,IC50 值为 11.43±0.36 μM。它在促进 Aβ 清除中刺激自噬。
Licochalcone B
T4S0350
Licochalcone B 是从Glycyrrhiza inflate 根中提取的。它能够抑制淀粉样蛋白 β 自聚集作用 (IC50=2.16 μM) ,分解预先形成的 Aβ42原纤维,并通过螯合金属离子抑制金属诱导的 Aβ42聚集。
MAO-B-IN-9
T60671
MAO-B-IN-9是一种可穿过血脑屏障的单胺氧化酶B MAO-B 抑制剂(IC50:0.18μM),具有有效性、选择性和时间依赖性。MAO-B-IN-9具有神经保护作用,可以防止Aβ1-42诱导的神经元细胞死亡,这可能与Aβ1-42的抗聚集作用有关。
2-O-Acetyl-20-hydroxyecdysone
TN1216
2-O-Acetyl-20-hydroxyecdysone 是存在于昆虫和陆生植物中的一种蜕皮激素,2-O-Acetyl-20-hydroxyecdysone 对 amyloid-β42 诱导的细胞毒性有抑制作用,能够通过促进纤维发生减少 Aβ 寡聚物的形成,将 Aβ 寡聚物转变为低毒性纤维。
1 2 3 4 5
联系我们
400-820-0310

上海市静安区江场三路238号8楼