6'-Methyl paeonol, a derivative of paeonol, inhibits abnormal depolarizations and reduces Amyloid β-induced ERK phosphorylation, exhibiting activity that alleviates Alzheimer’s Disease [1].

6'-Methyl paeonol (0.1-100 μM) demonstrates inhibitory effects on NMDA and AMPA-mediated neuronal depolarization, thus mitigating Aβ-driven abnormal depolarization. Western Blot Analysis [1] revealed that in the C2C12 cell line, a concentration of 100 μM with an incubation time of 2 hours reversed the Aβ-induced increase in ERK phosphorylation.

6'-Methyl paeonol (20 mg/kg, 皮下注射) 显著增强了J20小鼠在实验中对隐藏平台的定位能力，有效地改善了其学习与记忆功能[1]。使用模型：APP转基因C57BL/6小鼠（即J20小鼠）[1]；给药剂量与方式：每千克体重20毫克，通过皮下注射方式给药；研究结果：缩短了小鼠寻找隐藏平台的时间。