Amilo-5MER (5-MP) (TFA) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically inhibits the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER (TFA) helps reduce chronic inflammation, alleviating symptoms associated with rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research into autoimmune and chronic inflammatory diseases.