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Tauroursodeoxycholate (UR 906) 是一种天然的高度亲水性的三级胆汁酸。Tauroursodeoxycholate 可用于原发性胆汁性肝硬化 (PBC)、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤滞和肌萎缩性侧索硬化症的研究。

1-Deoxymannojirimycin hydrochloride 是一种选择性的 α1,2-甘露糖苷酶抑制剂，IC50值为 20 μM。它还抑制 HIV-1 毒株，抗病毒活性较差。

α-Lipoic Acid (DL-α-Lipoic acid) 是线粒体酶复合物的重要辅助因子，是一种抗氧化剂，可抑制NF-κB 依赖性的HIV-1LTR 活化。它还可诱导内质网应激介导的肝癌细胞凋亡。

Bufotalin (Bufotaline) 是一种从蟾酥中分离的类固醇内酯，可诱导癌细胞凋亡，也诱导内质网应激的激活，具有强大的抗肿瘤活性。

Thapsigargin 属于天然产物，是一种肌/内质网 Ca2+ ATP 酶 (SERCA) 的抑制剂，也是一种内质网应激诱导剂。Thapsigargin 通过阻断细胞将钙泵入肌浆和内质网的能力来提高胞浆钙浓度。

Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosolic calcium through Ryanodine receptor-mediated endoplasmic reticulum release

cis-4-Hydroxy-L-proline 是脯氨酸的一种类似物，抑制胶原蛋白的产生。它通过阻止三层螺旋胶原在细胞层上的沉积从而抑制成纤维细胞的生长。它还可抑制原发性N-亚硝基甲基脲诱导的大鼠乳腺肿瘤的生长。

Dibutyl phthalate (1,2-Benzenedicarboxylic acid) 是一种增塑剂，常见于工业制造，通过破坏从内质网到线粒体的 Ca（2+） 转移并引发随后的细胞焦亡而引起心脏损伤。Dibutyl phthalate 在斑马鱼大脑中诱导氧化损伤。

Ganoderic acid F 是一种灵芝酸。它具有抗肿瘤和抗转移的活性，与抑制血管生成和涉及细胞增殖和细胞死亡，致癌作用，氧化应激，钙信号传导和内质网应激的蛋白质改变等机制相关。

Paxilline 是一种来自 Penicillium paxilli 的吲哚生物碱霉菌毒素，是一种常用的大电导、电压和 Ca（2+） 依赖性 BK 型 K（+） 通道的特异性抑制剂，具有抗惊厥活性，抑制 BK 通道，抑制肌质网 Ca2+ 刺激的 ATP 酶 (SERCA)，可减轻沙利度胺引起的小鼠突触和认知功能障碍。

ABTL-0812 induces endoplasmic reticulum (ER) stress-mediated autophagy, and with anti-cancer activity.

Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex and it is the active agent found in Graviola leaf extract to act as an inhibitor of sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pu

Cyclopiazonic acid 是一种神经毒性次级代谢产物 (SM)，源于A. flavus，是一种纳摩尔内质网钙 ATP 酶抑制剂 (Ca2+ATPase; SERCA)，是植物细胞死亡的有效诱导剂。

Tauroursodeoxycholate (TUDCA ,Taurolite) dihydrate（牛磺熊去氧胆酸二水合物）是一种水溶性胆汁酸，具有内质网应激抑制、线粒体稳定化和抗凋亡作用，能够显著降低凋亡分子的表达，如Caspase-3和Caspase-12，并抑制ERK，减少内质网应激介导的细胞死亡。

D-Glucose 6-phosphate (D-葡萄糖-6-磷酸)是6号碳上的羟基被己糖激酶磷酸化的葡萄糖，参与糖酵解、糖异生和戊糖磷酸途径，也可以转化为糖原或淀粉储存。在肝脏中作为葡萄糖6-磷酸酶的底物，在内质网腔中作为己糖6-磷酸脱氢酶（H6PDH）的底物。

Kifunensine是一种发现于Kitasatosporia kifunense的生物碱，是糖基化途径(glycosylation)抑制剂和免疫调节剂，是高尔基体中的α-mannosidase I的强抑制剂，可用于研究内质网应激。

Xestospongin C ((-)-Xestospongin C) 是一种具有选择性的肌醇 1，4，5-三磷酸受体 (IP3R) 抑制剂，也是肌膜/内质网 Ca2+ ATP 酶 (SERCA) 的抑制剂，对 APP/PS1 AD 小鼠认知行为和病理学具有神经保护作用，可减轻阿尔茨海默病 APP/PS1 小鼠的认知和病理障碍。

Phosphatidylserine是一种天然存在于哺乳动物的磷脂，具有抗炎和抗动脉粥样硬化作用，能够激活PKC、中性鞘磷脂酶、C-raf-1蛋白激酶等参与多种信号通路激活的辅助因子。

Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system. They are produced from the combination of ceramide and UDP-galactose in the endoplasmic reticulum followed by sulfation in the Golgi apparatus. The ceramide portion contains variable fatty acid chain lengths, which are tissue- and pathology-dependent. Sulfatides are primarily found in the myelin sheath of oligodendrocytes and Schwann cells, with smaller chain lengths predominant during development and longer chain lengths predominant in mature cells. They accumulate in the lysosome of patients with metachromatic leukodystrophy, a disorder characterized by arylsulfatase A deficiency. Sulfatides are also located in pancreatic β-cells and inhibit insulin release from isolated rat pancreatic islet cells, suggesting a potential role in diabetes. Sulfatides can induce inflammation in glia in vitro and certain sulfatides, such as C24:1 3'-sulfo-galactosylceramide, can induce an immune response in vitro in mouse splenocytes. Sulfatides (bovine) (sodium salt) is a mixture of isolated bovine sulfatides.

Cyclic ADP-ribose ammonium (cADPR ammonium) is a powerful calcium mobilization second messenger synthesized from NAD+ by an ADP-ribosyl cyclase. It primarily raises cytosolic calcium levels through Ryanodine receptor-mediated release from the endoplasmic reticulum, while also facilitating extracellular influx through the opening of TRPM2 channels [1][2][3].

β-D-Glucopyranosyl abscisate (ABA-GE) is a hydrolyzable conjugate of abscisic acid (ABA), which predominantly accumulates in the vacuole and likely in the endoplasmic reticulum. The deconjugation of β-D-Glucopyranosyl abscisate enables a swift release of free ABA in response to abiotic stress factors like dehydration and salt stress. β-D-Glucopyranosyl abscisate plays a crucial role in maintaining ABA homeostasis.

Daphylloside, and asperuloside can be suggested as endoplasmic reticulum stress regulators.

Acetylshikonin 来源于紫草根，具有抗癌、抗炎作用。它是一种 AChE 抑制剂，具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂，对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。

α-Lipoic Acid sodium(Thioctic acid sodium)是一种抗氧化剂和线粒体酶复合物的重要辅助因子。α-Lipoic Acid sodium能够抑制NF-κB依赖性的HIV-1复制，诱导内质网应激介导的肝癌细胞凋亡，调节SREBP-1、FOXO1和Nrf2来改善高脂饮食诱导的肝脂肪变性。