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MAN1B1 Protein, Human, Recombinant (His)
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还可以货号 TMPJ-01384
别名 Mannosidase α Class 1B Member 1, Mannosidase Alpha Class 1B Member 1, Man9GlcNAc2-Specific-Processing α-Mannosidase, Man9GlcNAc2-Specific-Processing Alpha-Mannosidase, MAN1B1, ERMan1, ER α-1, ER Mannosidase 1, ER Alpha-1, Endoplasmic Reticulum Mannosyl-Oligosaccharide 1, 2-α-Mannosidase, 2-Mannosidase, 2-Alpha-Mannosidase
Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.
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MAN1B1 Protein, Human, Recombinant (His)
一键复制产品信息 还可以货号 TMPJ-01384 别名 Mannosidase α Class 1B Member 1, Mannosidase Alpha Class 1B Member 1, Man9GlcNAc2-Specific-Processing α-Mannosidase, Man9GlcNAc2-Specific-Processing Alpha-Mannosidase, MAN1B1, ERMan1, ER α-1, ER Mannosidase 1, ER Alpha-1, Endoplasmic Reticulum Mannosyl-Oligosaccharide 1, 2-α-Mannosidase, 2-Mannosidase, 2-Alpha-Mannosidase
Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 μg | ¥ 492 | 6-8日内发货 | |
| 10 μg | ¥ 820 | 6-8日内发货 | |
| 20 μg | ¥ 1,290 | 5日内发货 | |
| 50 μg | ¥ 2,480 | 5日内发货 | |
| 100 μg | ¥ 3,980 | 5日内发货 | |
| 200 μg | ¥ 6,420 | 5日内发货 | |
| 500 μg | ¥ 12,100 | 5日内发货 | |
| 1 mg | ¥ 17,300 | 5日内发货 |
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| 产品描述 | Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period. |
| 生物活性 | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| 研究背景 | Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period. |
| 种属 | Human |
| 表达系统 | HEK293 Cells |
| 标签 | C-6xHis |
| 蛋白编号 | Q9UKM7 |
| 氨基酸序列 | Asp106-Ala699 |
| 蛋白构建 | Asp106-Ala699 |
| 蛋白纯度 | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| 缓冲液 | Supplied as a 0.2 μm filtered solution of 50 mM Tris-HCl, 10 mM reduced Glutathione, pH 8.0. |
| 别名 | Mannosidase α Class 1B Member 1, Mannosidase Alpha Class 1B Member 1, Man9GlcNAc2-Specific-Processing α-Mannosidase, Man9GlcNAc2-Specific-Processing Alpha-Mannosidase, MAN1B1, ERMan1, ER α-1, ER Mannosidase 1, ER Alpha-1, Endoplasmic Reticulum Mannosyl-Oligosaccharide 1, 2-α-Mannosidase, 2-Mannosidase, 2-Alpha-Mannosidase |
| 内毒素 | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| 分子量 | 58-80 KDa (reducing condition) |
| 运输方式 | In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
| 存储 | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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