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Anti-Phospho-ERN1 (Ser724) Antibody (1J294)
还可以产品编号 TMAH-00896
别名 Phospho-ERN1 (S724), p-ERN1 (Ser724), p-ERN1 (S724), IRE1P, IRE1a, IRE1, hIRE1p, ERN1 (p-Ser724), ERN1 (p-S724), endoplasmic reticulum to nucleus signaling 1
Anti-Phospho-ERN1 (Ser724) Antibody (1J294) 是一种抗体，靶向 Phospho-ERN1 (Ser724)。Anti-Phospho-ERN1 (Ser724) Antibody (1J294) 可用于 ELISA, WB, IF。
Anti-Phospho-ERN1 (Ser724) Antibody (1J294)
Anti-Phospho-ERN1 (Ser724) Antibody (1J294)
还可以产品编号 TMAH-00896 别名 Phospho-ERN1 (S724), p-ERN1 (Ser724), p-ERN1 (S724), IRE1P, IRE1a, IRE1, hIRE1p, ERN1 (p-Ser724), ERN1 (p-S724), endoplasmic reticulum to nucleus signaling 1
Anti-Phospho-ERN1 (Ser724) Antibody (1J294) 是一种抗体，靶向 Phospho-ERN1 (Ser724)。Anti-Phospho-ERN1 (Ser724) Antibody (1J294) 可用于 ELISA, WB, IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,190 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-Phospho-ERN1 (Ser724) Antibody (1J294) is an antibody targeting Phospho-ERN1 (Ser724). Anti-Phospho-ERN1 (Ser724) Antibody (1J294) can be used in ELISA, WB, IF. |
| 别名 | Phospho-ERN1 (S724), p-ERN1 (Ser724), p-ERN1 (S724), IRE1P, IRE1a, IRE1, hIRE1p, ERN1 (p-Ser724), ERN1 (p-S724), endoplasmic reticulum to nucleus signaling 1 |
| Ig Type | Rabbit IgG |
| 克隆号 | 1J294 |
| 交叉反应 | Human |
| 验证活性 | 1. Western Blot -Positive WB detected in: 293 whole cell lysate, A549 whole cell lysate, Hela whole cell lysate (treated with Calyculin A or EGF) -All lanes: Phospho-ERN1 antibody at 0.75μg/ml -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 110 kDa -Observed band size: 110 kDa 2. Immunofluorescence staining of Hela cells with TMAH-00896 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| 应用 | ELISA, WB, IF |
| 推荐剂量 | WB:1:500-1:5000; IF:1:20-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Endoplasmic reticulum membrane; Single-pass type I membrane protein. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP. Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity. The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA. The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes. Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human Phospho-ERN1 (S724) |
| 抗原种属 | Human |
| 基因ID | 2081 |
| Uniprot ID | |
| 研究领域 | Signal Transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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