Anti-IRE1 Antibody (6U65)

Name: Anti-IRE1 Antibody (6U65)
Brand: TargetMol
SKU: TMAY-02142
Rating: 4.5 (1 reviews)

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产品编号 TMAY-02142

别名 IRE1P, IRE1a, IRE1, hIRE1p, endoplasmic reticulum to nucleus signaling 1

Anti-IRE1 Antibody (6U65) 是一种 Mouse 抗体，靶向 IRE1。Anti-IRE1 Antibody (6U65) 可用于 ELISA,IHC-P。

Anti-IRE1 Antibody (6U65)

还可以

产品编号 TMAY-02142 别名 IRE1P, IRE1a, IRE1, hIRE1p, endoplasmic reticulum to nucleus signaling 1

Anti-IRE1 Antibody (6U65) 是一种 Mouse 抗体，靶向 IRE1。Anti-IRE1 Antibody (6U65) 可用于 ELISA,IHC-P。

规格	价格	库存	数量
100 μL	¥ 1,689	5日内发货

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生物活性

产品描述	Anti-IRE1 Antibody (6U65) is a Mouse antibody targeting IRE1. Anti-IRE1 Antibody (6U65) can be used in ELISA,IHC-P.
别名	IRE1P, IRE1a, IRE1, hIRE1p, endoplasmic reticulum to nucleus signaling 1
Ig Type	Monoclonal Mouse IgG2b
克隆号	6U65
交叉反应	Human
验证活性	1. Immunochemical staining of human ERN1 in human tonsil with mouse monoclonal antibody (1:300, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human ERN1 in human liver with mouse monoclonal antibody (1:300, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human ERN1 in human epididymis with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections).
应用	ELISA,IHC-P
推荐剂量	ELISA: 1:1000-1:2000; IHC-P: 1:100-1:500
抗体种类	Monoclonal
宿主来源	Mouse
构建方式	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ERN1 / IRE1 (rh ERN1 / IRE1; TMPY-04413; O75460-1; Pro 465-Leu 977). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式	Protein A
性状	Liquid
缓冲液	0.2 μm filtered solution in PBS
研究背景	Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell death processes, significantly decreases proliferative processes. An enhanced expression of TP53 gene in ERN1 knockdown glioma cells correlates with the decreased level of ubiquitin ligase MDM2 and increased expression level of USP7 which deubiquitinates TP53 and MDM2 and induces TP53-dependent cell growth repression and apoptosis. Thus, the expression of genes encoding TP53 and related to TP53 factors depends upon the endoplasmic reticulum stress signaling as well as on hypoxia, and correlates with suppression of glioma growth under ERN1 knockdown. The dependence of insulin-like growth binding proteins as well as IGF2BP3 and HTRA1 gene expressions in U87 glioma cells on ERN1 signaling enzyme function and hypoxia, indicating its participation in the regulation of metabolic and proliferative processes via IGF/INS receptors, because endoplasmic reticulum stress is an important component of tumor growth and metabolic diseases.

偶联与修饰

偶联	Unconjugated

抗原信息

免疫原	Recombinant Human ERN1 / IRE1 protein (TMPY-04413)
抗原种属	Human

存储&运输

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式	Shipping with blue ice.