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Anti-IRE1 Antibody (6O834)
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产品编号 TMAY-02143
别名 IRE1P, IRE1a, IRE1, hIRE1p, endoplasmic reticulum to nucleus signaling 1
Anti-IRE1 Antibody (6O834) 是一种 Rabbit 抗体，靶向 IRE1。Anti-IRE1 Antibody (6O834) 可用于 ELISA。
Anti-IRE1 Antibody (6O834)
331 Anti-IRE1 Antibody (6O834)
还可以产品编号 TMAY-02143 别名 IRE1P, IRE1a, IRE1, hIRE1p, endoplasmic reticulum to nucleus signaling 1
Anti-IRE1 Antibody (6O834) 是一种 Rabbit 抗体，靶向 IRE1。Anti-IRE1 Antibody (6O834) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 2,279 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-IRE1 Antibody (6O834) is a Rabbit antibody targeting IRE1. Anti-IRE1 Antibody (6O834) can be used in ELISA. |
| 别名 | IRE1P, IRE1a, IRE1, hIRE1p, endoplasmic reticulum to nucleus signaling 1 |
| Ig Type | Rabbit IgG |
| 克隆号 | 6O834 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human ERN1 / IRE1 (rh ERN1 / IRE1; TMPY-04413; O75460-1; Pro465-Leu977). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell death processes, significantly decreases proliferative processes. An enhanced expression of TP53 gene in ERN1 knockdown glioma cells correlates with the decreased level of ubiquitin ligase MDM2 and increased expression level of USP7 which deubiquitinates TP53 and MDM2 and induces TP53-dependent cell growth repression and apoptosis. Thus, the expression of genes encoding TP53 and related to TP53 factors depends upon the endoplasmic reticulum stress signaling as well as on hypoxia, and correlates with suppression of glioma growth under ERN1 knockdown. The dependence of insulin-like growth binding proteins as well as IGF2BP3 and HTRA1 gene expressions in U87 glioma cells on ERN1 signaling enzyme function and hypoxia, indicating its participation in the regulation of metabolic and proliferative processes via IGF/INS receptors, because endoplasmic reticulum stress is an important component of tumor growth and metabolic diseases. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human ERN1 / IRE1 protein (TMPY-04413) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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