CXCR

The CXCR signaling pathway family mainly comprises chemokines and chemokine receptors and CXCR consists of about 330 amino acids. The seven transmembrane regions divide the molecule into an extracellular free N-terminus, three extracellular loops, three intracellular loops, and several C-terminal portions.

Cat. No.	Product Name	CAS No.	Purity
T10905	CXCR2-IN-1 化合物CXCR2-IN-1	1873376-49-8	98%
T10905	CXCR2-IN-1是可渗透中枢神经系统的 CXCR2拮抗剂，pIC50值为9.3。
T68052	Delmetacin 地美辛	16401-80-2	98%
T68052	Delmetacin 是一种非甾体抗炎化合物，具有抗炎和镇痛活性，对 CXC 趋化因子受体 CXCR1 具有抑制作用。
T25131	AZD8309 化合物AZD8309	333742-48-6	98%
T25131	AZD8309 是一种强效的、可口服的趋化因子受体CXCR2的拮抗剂，能够调节中性粒细胞的转运，可显著降低胰腺和肺部的MPO，并降低胰腺内的胰蛋白酶和弹性蛋白酶活性。AZD8309 能够用于研究炎症系列疾病。
T10635	Burixafor hydrobromide 化合物 T10635	1191450-19-7	98%
T10635	Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in tre...
T11140	E6130 化合物 T11140	1427058-33-0	98%
T11140	E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.
T16933	SRT3190 化合物 T16933	1204707-73-2	98%
T16933	SRT3190 is an antagonist of CXCR2.
T12269L	NUCC-390 dihydrochloride (1060524-97-1 free base) 化合物 T12269L	T12269L	98%
T12269L	NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.
TN5227	(+/-)-Vestitol 化合物 TN5227	56701-24-7	98%
TN5227	Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to...
T16864	SCH 563705 化合物 T16864	473728-58-4	98%
T16864	SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively).
T19386	ITIC 化合物 T19386	1664293-06-4	98%
T19386	ITIC, a non-fullerene acceptor, demonstrates exceptional thermal stability and exhibits a glass-crystal transition at a significantly lower temperature than its ...
T6764	ATI-2341 化合物ATI-2341	1337878-62-2	98%
T6764	ATI2341 是 C-X-C 趋化因子受体 4 型功能选择性变构激动剂，作为偏向配体有利于 Gα1 激活。它是一种变构激动剂，可激活抑制性异源三聚体 G 蛋白 (Gi) 以促进抑制 cAMP 产生并诱导钙动员。
T19385	ITIC-4F 化合物 T19385	2097998-59-7	98%
T19385	ITIC-4F, an indacenodithienothiophene (IDTT)-based postfullerene electron acceptor, exhibits wide applicability in high-efficiency binary and ternary single-junc...
TP2141	Balixafortide TFA (1051366-32-5 free base) 化合物 TP2141	TP2141	98%
TP2141	Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large pane...
T14665	Motixafortide 化合物 T14665	664334-36-5	98%
T14665	Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).
TP2141L	Balixafortide 化合物 TP2141L	1051366-32-5	98%
TP2141L	Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM and it is also a potent hematopoietic stem and prog...
T0801	Tannic acid 单宁酸	1401-55-4	98%
T0801	Tannic acid 是新型hERG 通道阻塞剂，IC50为 3.4 μM。
T1739	WZ811 化合物WZ811	55778-02-4	98%
T1739	WZ811 是可口服的高竞争性CXCR4拮抗剂，抑制细胞中 CXCR4/SDF-1 介导的 cAMP 水平调节和 SDF-1 诱导的基质胶侵入，EC50为 1.2 和 5.2 nM。
T3047	SRT3109 化合物SRT3109	1204707-71-0	98%
T3047	SRT3109 是 CXCR2拮抗剂，pIC50值为 8.2，可用于趋化因子介导的疾病研究。
T0617	Nicotinamide N-oxide 烟酰胺-N-氧化物	1986-81-8	98%
T0617	Nicotinamide N-oxide 是生物体内烟酰胺分解代谢物，是高效选择性CXCR2受体拮抗剂。
T10297L	AMG 487 化合物AMG 487	473719-41-4	98%
T10297L	AMG 487 是可口服的选择性趋化因子受体3拮抗剂，对 I-IP-10、I-ITAC 和 MIG 的 IC50 值分别为 8、15 和 36nM。