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CXCR

CXCR

The CXCR signaling pathway family mainly comprises chemokines and chemokine receptors and CXCR consists of about 330 amino acids. The seven transmembrane regions divide the molecule into an extracellular free N-terminus, three extracellular loops, three intracellular loops, and several C-terminal portions.
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Cat. No. Product Name CAS No. Purity Chemical Structure
T10905 CXCR2-IN-1
化合物CXCR2-IN-1
1873376-49-8 98%
CXCR2-IN-1是可渗透中枢神经系统的 CXCR2拮抗剂,pIC50值为9.3。
T68052 Delmetacin
地美辛
16401-80-2 98%
Delmetacin 是一种非甾体抗炎化合物,具有抗炎和镇痛活性,对 CXC 趋化因子受体 CXCR1 具有抑制作用。
T25131 AZD8309
化合物AZD8309
333742-48-6 98%
AZD8309 是一种强效的、可口服的趋化因子受体CXCR2的拮抗剂, 能够调节中性粒细胞的转运,可显著降低胰腺和肺部的MPO,并降低胰腺内的胰蛋白酶和弹性蛋白酶活性。AZD8309 能够用于研究炎症系列疾病。
T10635 Burixafor hydrobromide
化合物 T10635
1191450-19-7 98%
Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in tre...
T11140 E6130
化合物 T11140
1427058-33-0 98%
E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.
T16933 SRT3190
化合物 T16933
1204707-73-2 98%
SRT3190 is an antagonist of CXCR2.
T12269L NUCC-390 dihydrochloride (1060524-97-1 free base)
化合物 T12269L
T12269L 98%
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.
TN5227 (+/-)-Vestitol
化合物 TN5227
56701-24-7 98%
Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to...
T16864 SCH 563705
化合物 T16864
473728-58-4 98%
SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively).
T19386 ITIC
化合物 T19386
1664293-06-4 98%
ITIC, a non-fullerene acceptor, demonstrates exceptional thermal stability and exhibits a glass-crystal transition at a significantly lower temperature than its ...
T6764 ATI-2341
化合物ATI-2341
1337878-62-2 98%
ATI2341 是 C-X-C 趋化因子受体 4 型功能选择性变构激动剂,作为偏向配体有利于 Gα1 激活。它是一种变构激动剂,可激活抑制性异源三聚体 G 蛋白 (Gi) 以促进抑制 cAMP 产生并诱导钙动员。
T19385 ITIC-4F
化合物 T19385
2097998-59-7 98%
ITIC-4F, an indacenodithienothiophene (IDTT)-based postfullerene electron acceptor, exhibits wide applicability in high-efficiency binary and ternary single-junc...
TP2141 Balixafortide TFA (1051366-32-5 free base)
化合物 TP2141
TP2141 98%
Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large pane...
T14665 Motixafortide
化合物 T14665
664334-36-5 98%
Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).
TP2141L Balixafortide
化合物 TP2141L
1051366-32-5 98%
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM and it is also a potent hematopoietic stem and prog...
T0801 Tannic acid
单宁酸
1401-55-4 98%
Tannic acid 是新型hERG 通道阻塞剂,IC50为 3.4 μM。
T1739 WZ811
化合物WZ811
55778-02-4 98%
WZ811 是可口服的高竞争性CXCR4拮抗剂,抑制细胞中 CXCR4/SDF-1 介导的 cAMP 水平调节和 SDF-1 诱导的基质胶侵入,EC50为 1.2 和 5.2 nM。
T3047 SRT3109
化合物SRT3109
1204707-71-0 98%
SRT3109 是 CXCR2拮抗剂,pIC50值为 8.2,可用于趋化因子介导的疾病研究。
T0617 Nicotinamide N-oxide
烟酰胺-N-氧化物
1986-81-8 98%
Nicotinamide N-oxide 是生物体内烟酰胺分解代谢物,是高效选择性CXCR2受体拮抗剂。
T10297L AMG 487
化合物AMG 487
473719-41-4 98%
AMG 487 是可口服的选择性趋化因子受体3拮抗剂,对 I-IP-10、I-ITAC 和 MIG 的 IC50 值分别为 8、15 和 36nM。
CXCR2-IN-1
T10905
CXCR2-IN-1是可渗透中枢神经系统的 CXCR2拮抗剂,pIC50值为9.3。
Delmetacin
T68052
Delmetacin 是一种非甾体抗炎化合物,具有抗炎和镇痛活性,对 CXC 趋化因子受体 CXCR1 具有抑制作用。
AZD8309
T25131
AZD8309 是一种强效的、可口服的趋化因子受体CXCR2的拮抗剂, 能够调节中性粒细胞的转运,可显著降低胰腺和肺部的MPO,并降低胰腺内的胰蛋白酶和弹性蛋白酶活性。AZD8309 能够用于研究炎症系列疾病。
Burixafor hydrobromide
T10635
Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in tre...
E6130
T11140
E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.
SRT3190
T16933
SRT3190 is an antagonist of CXCR2.
NUCC-390 dihydrochloride (1060524-97-1 free base)
T12269L
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.
(+/-)-Vestitol
TN5227
Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to...
SCH 563705
T16864
SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively).
ITIC
T19386
ITIC, a non-fullerene acceptor, demonstrates exceptional thermal stability and exhibits a glass-crystal transition at a significantly lower temperature than its ...
ATI-2341
T6764
ATI2341 是 C-X-C 趋化因子受体 4 型功能选择性变构激动剂,作为偏向配体有利于 Gα1 激活。它是一种变构激动剂,可激活抑制性异源三聚体 G 蛋白 (Gi) 以促进抑制 cAMP 产生并诱导钙动员。
ITIC-4F
T19385
ITIC-4F, an indacenodithienothiophene (IDTT)-based postfullerene electron acceptor, exhibits wide applicability in high-efficiency binary and ternary single-junc...
Balixafortide TFA (1051366-32-5 free base)
TP2141
Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large pane...
Motixafortide
T14665
Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).
Balixafortide
TP2141L
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM and it is also a potent hematopoietic stem and prog...
Tannic acid
T0801
Tannic acid 是新型hERG 通道阻塞剂,IC50为 3.4 μM。
WZ811
T1739
WZ811 是可口服的高竞争性CXCR4拮抗剂,抑制细胞中 CXCR4/SDF-1 介导的 cAMP 水平调节和 SDF-1 诱导的基质胶侵入,EC50为 1.2 和 5.2 nM。
SRT3109
T3047
SRT3109 是 CXCR2拮抗剂,pIC50值为 8.2,可用于趋化因子介导的疾病研究。
Nicotinamide N-oxide
T0617
Nicotinamide N-oxide 是生物体内烟酰胺分解代谢物,是高效选择性CXCR2受体拮抗剂。
AMG 487
T10297L
AMG 487 是可口服的选择性趋化因子受体3拮抗剂,对 I-IP-10、I-ITAC 和 MIG 的 IC50 值分别为 8、15 和 36nM。
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