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CXCR

CXCR

The CXCR signaling pathway family mainly comprises chemokines and chemokine receptors and CXCR consists of about 330 amino acids. The seven transmembrane regions divide the molecule into an extracellular free N-terminus, three extracellular loops, three intracellular loops, and several C-terminal portions.
TargetMol
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Cat. No. Product Name CAS No. Purity Chemical Structure
T10635 Burixafor hydrobromide
化合物 T10635
1191450-19-7 98%
TargetMol Chemical Structure Burixafor hydrobromide
Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in tre...
T78879 CXCR4-IN-2
化合物 CXCR4-IN-2
98%
TargetMol Chemical Structure CXCR4-IN-2
CXCR4-IN-2(compound A1)是一款具有抗癌活性的双功能氟化小分子,是CXCR4的强效抑制剂。它对小鼠结直肠癌(CRC)细胞展现出显著的细胞毒性(IC50:60 μg/mL;72小时)和抗增殖能力,能够引导细胞在G2/M期发生阻滞并诱导细胞凋亡(apoptosis)。
T79059 CXCR4-IN-1
化合物 CXCR4-IN-1
2304750-48-7 98%
TargetMol Chemical Structure CXCR4-IN-1
CXCR4-IN-1 (Example C5) 为CXCR4抑制剂,IC50值为20 nM。该化合物主要适用于癌症、HIV、糖尿病视网膜病变、炎症等领域的研究。
T79070 Pentixafor
化合物 Pentixafor
1341207-62-2 98%
TargetMol Chemical Structure Pentixafor
Pentixafor是靶向CXCR4受体的肽类化合物,可结合68Gallium (68Ga) 进行正电子发射断层扫描 (PET) 成像。
T80130 SDF-1α (human)
化合物 SDF-1α (human)
1268129-65-2 98%
TargetMol Chemical Structure SDF-1α (human)
SDF-1α (human) 是一种能够与CXCR4受体相结合的单核细胞趋化剂,它在心肌梗死模型中的干细胞归巢、维持、生存、增殖、心肌细胞修复、血管形成以及心室重构过程扮演关键角色。SDF-1α (human) 常用于心血管病研究。
T80216 DOTA-CXCR4-L
化合物 DOTA-CXCR4-L
98%
TargetMol Chemical Structure DOTA-CXCR4-L
DOTA-CXCR4-L为针对CXCR4的靶向肽,适用于癌症研究,如胶质母细胞瘤和三阴性乳腺癌。
T80525 E70K
化合物 E70K
98%
TargetMol Chemical Structure E70K
E70K是CXCL8 C端肽的变体,其第70位的谷氨酸被赖氨酸取代。该化合物能够降低炎症过程中中性粒细胞的粘附与迁移。
T11140 E6130
化合物 T11140
1427058-33-0 98%
TargetMol Chemical Structure E6130
E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.
T16933 SRT3190
化合物 T16933
1204707-73-2 98%
TargetMol Chemical Structure SRT3190
SRT3190 is an antagonist of CXCR2.
T12269L NUCC-390 dihydrochloride (1060524-97-1 free base)
化合物 T12269L
98%
TargetMol Chemical Structure NUCC-390 dihydrochloride (1060524-97-1 free base)
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.
TN5227 (+/-)-Vestitol
化合物 TN5227
56701-24-7 98%
TargetMol Chemical Structure (+/-)-Vestitol
Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to...
T16864 SCH 563705
化合物 T16864
473728-58-4 98%
TargetMol Chemical Structure SCH 563705
SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively).
T19386 ITIC
化合物 T19386
1664293-06-4 98%
TargetMol Chemical Structure ITIC
ITIC, a non-fullerene acceptor, demonstrates exceptional thermal stability and exhibits a glass-crystal transition at a significantly lower temperature than its ...
T6764 ATI-2341
化合物ATI-2341
1337878-62-2 98%
TargetMol Chemical Structure ATI-2341
ATI-2341 是 C-X-C 趋化因子受体 4 型功能选择性变构激动剂,作为偏向配体有利于 Gα1 激活。它是一种变构激动剂,可激活抑制性异源三聚体 G 蛋白 (Gi) 以促进抑制 cAMP 产生并诱导钙动员。
T19385 ITIC-4F
化合物 T19385
2097998-59-7 98%
TargetMol Chemical Structure ITIC-4F
ITIC-4F, an indacenodithienothiophene (IDTT)-based postfullerene electron acceptor, exhibits wide applicability in high-efficiency binary and ternary single-junc...
TP2141 Balixafortide TFA (1051366-32-5 free base)
化合物 TP2141
98%
TargetMol Chemical Structure Balixafortide TFA (1051366-32-5 free base)
Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large pane...
T14665 Motixafortide
化合物 T14665
664334-36-5 98%
TargetMol Chemical Structure Motixafortide
Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).
TP2141L Balixafortide
化合物 TP2141L
1051366-32-5 98%
TargetMol Chemical Structure Balixafortide
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM and it is also a potent hematopoietic stem and prog...
T76782 Mogamulizumab
莫格利珠单抗
1159266-37-1 SDS-PAGE:97.3%;SEC-HPLC:99.4%
Mogamulizumab
Mogamulizumab (KW-0761) 是一种针对 T 细胞 CC 趋化因子受体 4 的 单克隆抗体。Mogamulizumab 具有抗癌活性,通过抗体依赖性细胞毒性 (ADCC) 消除肿瘤细胞,可用于研究癌症、成人T细胞白血病/淋巴瘤 (ATLL)、皮肤T细胞淋巴瘤(CTCL)。
T76794 Ulocuplumab
乌洛鲁单抗
1375830-34-4 SDS-PAGE:97.2%;SEC-HPLC:96.2%
Ulocuplumab
Ulocuplumab (BMS-936564) 是一种完全人 抗 CXCR4 的 IgG4  抗体。Ulocplumab 在急性髓系白血病 (AML),非霍奇金淋巴瘤 (NHL) 和多发性骨髓瘤移植模型中展现出抗肿瘤活性。Ulocplumab 对 CXCL12 介导的慢性淋巴细胞白血病 (CLL) 细胞在 CXCR4 ...
Burixafor hydrobromide
T10635
Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in tre...
CXCR4-IN-2
T78879
CXCR4-IN-2(compound A1)是一款具有抗癌活性的双功能氟化小分子,是CXCR4的强效抑制剂。它对小鼠结直肠癌(CRC)细胞展现出显著的细胞毒性(IC50:60 μg/mL;72小时)和抗增殖能力,能够引导细胞在G2/M期发生阻滞并诱导细胞凋亡(apoptosis)。
CXCR4-IN-1
T79059
CXCR4-IN-1 (Example C5) 为CXCR4抑制剂,IC50值为20 nM。该化合物主要适用于癌症、HIV、糖尿病视网膜病变、炎症等领域的研究。
Pentixafor
T79070
Pentixafor是靶向CXCR4受体的肽类化合物,可结合68Gallium (68Ga) 进行正电子发射断层扫描 (PET) 成像。
SDF-1α (human)
T80130
SDF-1α (human) 是一种能够与CXCR4受体相结合的单核细胞趋化剂,它在心肌梗死模型中的干细胞归巢、维持、生存、增殖、心肌细胞修复、血管形成以及心室重构过程扮演关键角色。SDF-1α (human) 常用于心血管病研究。
DOTA-CXCR4-L
T80216
DOTA-CXCR4-L为针对CXCR4的靶向肽,适用于癌症研究,如胶质母细胞瘤和三阴性乳腺癌。
E70K
T80525
E70K是CXCL8 C端肽的变体,其第70位的谷氨酸被赖氨酸取代。该化合物能够降低炎症过程中中性粒细胞的粘附与迁移。
E6130
T11140
E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.
SRT3190
T16933
SRT3190 is an antagonist of CXCR2.
NUCC-390 dihydrochloride (1060524-97-1 free base)
T12269L
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.
(+/-)-Vestitol
TN5227
Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to...
SCH 563705
T16864
SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively).
ITIC
T19386
ITIC, a non-fullerene acceptor, demonstrates exceptional thermal stability and exhibits a glass-crystal transition at a significantly lower temperature than its ...
ATI-2341
T6764
ATI-2341 是 C-X-C 趋化因子受体 4 型功能选择性变构激动剂,作为偏向配体有利于 Gα1 激活。它是一种变构激动剂,可激活抑制性异源三聚体 G 蛋白 (Gi) 以促进抑制 cAMP 产生并诱导钙动员。
ITIC-4F
T19385
ITIC-4F, an indacenodithienothiophene (IDTT)-based postfullerene electron acceptor, exhibits wide applicability in high-efficiency binary and ternary single-junc...
Balixafortide TFA (1051366-32-5 free base)
TP2141
Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large pane...
Motixafortide
T14665
Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).
Balixafortide
TP2141L
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM and it is also a potent hematopoietic stem and prog...
Mogamulizumab
T76782
Mogamulizumab (KW-0761) 是一种针对 T 细胞 CC 趋化因子受体 4 的 单克隆抗体。Mogamulizumab 具有抗癌活性,通过抗体依赖性细胞毒性 (ADCC) 消除肿瘤细胞,可用于研究癌症、成人T细胞白血病/淋巴瘤 (ATLL)、皮肤T细胞淋巴瘤(CTCL)。
Ulocuplumab
T76794
Ulocuplumab (BMS-936564) 是一种完全人 抗 CXCR4 的 IgG4  抗体。Ulocplumab 在急性髓系白血病 (AML),非霍奇金淋巴瘤 (NHL) 和多发性骨髓瘤移植模型中展现出抗肿瘤活性。Ulocplumab 对 CXCL12 介导的慢性淋巴细胞白血病 (CLL) 细胞在 CXCR4 ...
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