pCXCL8-1aa is an anti-inflammatory peptide. It competitively inhibits the binding of CXCL8 to glycosaminoglycans by binding with high affinity to glycosaminoglycans like heparan sulfate (HS). This action reduces the presentation of CXCL8 on the surface of vascular endothelial cells, thereby inhibiting neutrophil migration and the inflammatory response. pCXCL8-1aa is useful for research in inflammatory diseases such as rheumatoid arthritis.